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Endometrium implantation and ectopic pregnancy

Science China(Life Sciences) 2004年第4期47卷 293-302页

作者： LIU Yixun State Key Laboratory of Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100080China

Embryo in uterine implantation is a complex and multifactor-related process and is a downstream and ideal point for woman fertility control. Understanding the cellular and molecular mechanism of implantation is a prerequisite for development of anti-implantation contraceptives. In spite of considerable accumulation of information from the laboratory animals that has been achieved, it is difficult to generate such information in human due to ethical restriction and experimental limitation, and the present knowledge for understanding the definitive mechanisms which control these events remains elusive. Embryo implantation can also occur outside uterus. Some women with abdominal pregnancies could successfully complete the processes of gestation and bear normal babies, implying that implantation itself may be not an endometrium-specific process. Reproductive biologists should cooperate with gynecologists to further comparatively study the molecular and cellular mechanisms of implantation normally occurring in endometrium and abnormally appearing outside uterine cavity. Such collaborative studies may generate new important information for developing anti-implantation contraceptive and for techniques of accurate diagnosis of ectopic pregnancy. A specially designed GnRH-2 analog and a combination use of low dose RU486 and gossypol as anti-implantation contraceptives have been suggested. Keywords embryo implantation - implantation window - materno-embryonic dialogue - ectopic pregnancy

关键词： embryo implantation,implantation window,materno-embryonic dialogue,ectopic pregnancy.

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Expression of vascular endothelial growth factor in rat ovary during pregnancy.and postpartum

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Science China(Life Sciences) 2002年第4期45卷 379-387页

作者：李庆雷邵龙江祝诚王红梅倪江林海燕段恩奎 State Key Laboratory of Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100080China Laboratory of Reproductive Endocrinology Harbin Medical University Harbin 150086 China State Key Laboratory of Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100080China Laboratory of Reproductive Endocrinology Harbin Medical University Harbin 150086 China

The expressions of vascular endothelial growth factor (VEGF) in rat ovarian follicles and corpus luteum (CL) during different stages of pregnancy.and postpartum were investigated. In addition, the effect of tumor necrosis factor-α (TNF-α) on VEGF expression was examined. VEGF mRNA was localized in granulosa cells of preantral follicles, as well as in the granulosa and theca cells of small antral follicles, but not in large antral follicles. VEGF transcripts were amplified in rat CL during pregnancy.and postpartum using RT-PCR. The mRNA expression reached the maximal level on day 7, maintained it on days 9-18, decreased after day 18, and was minimal on day 1 postpartum. Western blot showed a 23 ku VEGF protein band in rat CL. Expression of VEGF protein varied in a similar way to that of its mRNA. Treatment with TNF-α at a dosage of 3000 IU/kg on day 4 of pregnancy.significantly increased VEGF expression in rat CL. It is suggested that the down-regulation of VEGF expression in large antral follicles may be one factor that contributes to the termination of ovulation in rat ovary during pregnancy. VEGF may be implicated in the CL formation and maintenance via regulating angiogenesis, and its expression is regulated by TNF-α.

关键词： VEGF, TNF-α, follicular development, corpus luteum, pregnancy.

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大白鼠妊娠早期(1—6天)子宫孕酮受体的变化

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Current Zoology 1985年第2期31卷 125-131页

作者：瞿敬贤南通医学院生理教研室上海市计划生育科学研究所

本实验中大鼠妊娠第三天（D;）出现血浆孕酮含量和子宫细胞胞核中孕酮受体含量显著同步升高和胞质中孕酮受体含量明显下降的现象,为D;胚泡着床准备了必要的条件。D;时血浆孕酮,胞质和胞核中孕酮受体以及子宫重量均升高,标志胚泡着床后... 详细信息

本实验中大鼠妊娠第三天（D;）出现血浆孕酮含量和子宫细胞胞核中孕酮受体含量显著同步升高和胞质中孕酮受体含量明显下降的现象,为D;胚泡着床准备了必要的条件。D;时血浆孕酮,胞质和胞核中孕酮受体以及子宫重量均升高,标志胚泡着床后的生理变化。

关键词： Progesterone receptors Uterus Rat Implantation pregnancy.

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ORF 9371衍生物的合成及其抗着床抗早孕活性筛选

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中国药物化学杂志 1990年第1期 77-79页

作者：姚军丁惟培王菊英石建平常翠芳同济医科大学计划生育研究所

甾体口服避孕药发展到今天,人们已把注意力集中在具有抗着床抗早孕而且雌激素活性较小的新甾体药物,近年来已发现一些有希望的化合物,如Ru 486,RMI 12936,STS 557,ORF 9371,炔诺酮肟等。 ORF 9371(17β-乙酰氧基-17α-孕甾-4-烯-20-炔-3... 详细信息

甾体口服避孕药发展到今天,人们已把注意力集中在具有抗着床抗早孕而且雌激素活性较小的新甾体药物,近年来已发现一些有希望的化合物,如Ru 486,RMI 12936,STS 557,ORF 9371,炔诺酮肟等。 ORF 9371(17β-乙酰氧基-17α-孕甾-4-烯-20-炔-3-酮肟,5a),文献报道具有较好的抗着床抗早孕活性,其作用机理可能亦与抗孕酮有关。

关键词： ORF 9371 5α-dihydro ORF 9371 antiimplantation, termination of early pregnancy.

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