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Development and Application of Prime editing in Plants

Rice science 2023年第6期30卷 509-522页

作者： LIU Tingting ZOU Jinpeng YANG Xi WANG Kejian RAO Yuchun WANG Chun State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteHangzhou 310006China College of Life Science and Technology Huazhong Agricultural UniversityWuhan 430070China College of Life Sciences Zhejiang Normal UniversityJinhua 321004China

Clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein(Cas)-mediated genome editing has greatly accelerated progress in plant genetic research and agricultural breeding by enabling targeted genomic ***,the prime editing system,derived from the CRISPR/Cas system,has opened the door for even more precise genome *** editing has the capability to facilitate all 12 types of base-to-base conversions,as well as desired insertions or deletions of fragments,without inducing double-strand breaks and requiring donor DNA *** a short time,prime editing has been rapidly verified as functional in various plants,and can be used in plant genome functional analysis as well as precision breeding of *** this review,we summarize the emergence and development of prime editing,highlight recent advances in improving its efficiency in plants,introduce the current applications of prime editing in plants,and look forward to future prospects for utilizing prime editing in genetic improvement and precision molecular breeding.

关键词： prime editing CRISPR/Cas precision genome editing crop breeding

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Plant base editing and prime editing:The current status and future perspectives

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Journal of Integrative Plant Biology 2023年第2期65卷 444-467页

作者： Jingying Li Chen Zhang Yubing He Shaoya Li Lei Yan Yucai Li Ziwei Zhu Lanqin Xia Institute of Crop Sciences(ICS) Chinese Academy of Agricultural Sciences(CAAS)Beijing 100081China National Nanfan Research Institute(Sanya) Chinese Academy of Agricultural Sciences/Hainan Yazhou Bay Seed LaboratorySanya 572024China

Precise replacement of an allele with an elite allele controlling an important agronomic trait in a predefined manner by gene editing technologies is highly desirable in crop *** editing and prime editing are two newly developed precision gene editing systems which can introduce the substitution of a single base and install the desired short indels to the target loci in the absence of double-strand breaks and donor repair templates,*** their discoveries,various strategies have been attempted to optimize both base editor(BE)and prime editor(PE)in order to improve the precise editing efficacy,specificity,and expand the targeting ***,we summarize the latest development of various BEs and PEs,as well as their applications in *** on these progresses,we recommend the appropriate BEs and PEs for both basic plant research and crop ***,we propose the perspectives for further optimization of these two *** envision that both BEs and PEs will become the routine and customized precise gene editing tools for both plant biological research and crop improvement in the near future.

关键词： base editing CRISPR/Cas plants precision genome editing prime editing

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