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Quantitative redox imaging biomarkers for studying tissue metabolic state and its heterogeneity

Journal of Innovative Optical Health Sciences 2014年第2期7卷 109-128页

作者： He N.Xu Lin Z.Li Department of RadiologyBrtton Chance Laboratory of Redoa Imaging Johnson Research Foundation Departmentof Biochemistry and BiophysicsPerelman School of MedicineUniversity of Pennsyluania PhiladelphiaPAUSA

NAD+/NADH redox state has been implicated in many diseases such as cancer and diabetes aswell as in the regulation of embryonic development and aging,To fluorimetrically sssthemitochondrial redox state,*** and co-workers measured the fluorescence of NADH andoxidized flavoproteins(Fp)including favin-adenine-dinucleotide(FAD)and demonstrated theirratio(*** redox ratio)is a sensitive indicator of the mitochondrial redox states.,The Chanceredox sca mer was built to simult aneously measure NADH and Fp in tisue at submilimeter scalein 3D using the freeze-trap *** paper summarizes our recent research experience,development and new applications of the redox scanning technique in collaboration with *** beginning in *** initiated or actively involved in many of the projectsduring the last several years of his *** advanced the redox scanning technigue by measuringthe nominal concentrations(in reference to the frozen solution standards)of the endogenousfuorescent analy tes,i.e.,[NADH]and[rp]to quantify the redox ratios in various *** advancement has enabled us to identify an array of the redox indices as quantitativeimaging,biomarkers(including[NADH],[Fp],[Fp]/[NADH]+[Fp],[NADH]/[Fp],and theirstandard deviations)for studying some important biological questions on cancer and normaltsue *** found that the redox indices were asociated or changed with(NADH)tumorigenesis(cancer versus non-cancer of human breast tisue biopsies);(2)tumor metastaticpotential;(3)tumor glucose uptake;(4)tumor p53 stat us;(5)PI3K pathway activation in pre-malignant tissue;(6)therapeutic ffects on tumors;(7)embryonic stem cell diferentiation;(8)the heart under fasting,Together,our work demonstrated that the tisue redox indices obtainedfrom the redox scanning technique may provide usefil information about tisue met abolism and physiology status in normal and diseased *** Chance redox scanner and other redoximaging techniques may ha

关键词： Tumor progresion mitochondria met astasis met astatic potential pre-malignancy NADH Fp FAD redox ratio

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