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Assessment of volumetric bone mineral density of the femoral neck in postmenopausal women with and without vertebral fractures using quantitative multi-slice CT

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第7期10卷 499-504页

作者： Sheng-yong WU Hui-hui JIA Didier HANS Jing LAN Li-ying WANG Jing-xue LI Yue-zeng CAI Department of Radiology Tianjin First Central Hospital Tianjin 300192 China Department of Radiology General Hospital of Tianjin Medical University Tianjin 300052 China Center of Bone Diseases Department of Bone and Joint Lausanne University Hospital 1011 Lausanne Switzerland

Objective： To demonstrate the validity and reliability of volumetric quantitative computed tomography （vQCT） with multi-slice computed tomography （MSCT） and dual energy X-ray absorptiometry （DXA） for hip bone mineral density （BMD） measurements, and to compare the differences between the two techniques in discriminating postmenopausal women with osteoporosis-related vertebral fractures from those without. Methods： Ninety subjects were enrolled and divided into three groups based on the BMD values of the lumbar spine and/or the femoral neck by DXA. Groups 1 and 2 consisted of postmenopausal women with BMD changes 〈-2SD, with and without radiographically confirmed vertebral fracture （n= 11 and 33, respectively）. Group 3 comprised normal controls with BMD changes 〉-ISD （n-46）. Post-MSCT （GE, LightSpeed16） scan reconstructed images of the abdominal-pelvic region, 1.25 mm thick per slice, were processed by OsteoCAD software to calculate the following parameters： volumetric BMD values of trabecular bone （TRAB）, cortical bone （CORT）, and integral bone （INTGL） of the left femoral neck, femoral neck axis length （NAL）, and minimum cross-section area （mCSA）. DXA BMD measurements of the lumbar spine （AP-SPINE） and the left femoral neck （NECK） also were performed for each subject. Results： The values of all seven parameters were significantly lower in subjects of Groups 1 and 2 than in normal postmenopausal women （P〈0.05, respectively）. Comparing Groups 1 and 2, 3D-TRAB and 3D-INTGL were significantly lower in postmenopausal women with vertebral fracture（s） [（109.8±9.61） and （243.3±33.0） mg/cm^3, respectively] than in those without [（148.9±7.47） and （285.4±17.8） mg/cm^3, respectively] （P〈0.05, respectively）, but no significant differences were evident in AP-SPINE or NECK BMD. Conclusion： the femoral neck-derived volumetric BMD parameters using vQCT appeared better than the DXA-derived ones in discriminating osteoporotic postmenopausal women with vertebral fractures from those wit

关键词： Osteoporosis Bone mineral density (BMD) Volumetric QCT Hip fracture postmenopausal women

Relationships between endothelial nitric oxide synthase gene polymorphisms and osteoporosis in postmenopausal women

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第8期10卷 609-618页

作者： Shun-zhi LIU Hong YAN Wei-kun HOU Peng XU Juan TIAN Li-fang TIAN Bo-feng ZHU Jie MA She-min LU Department of Public Health School of Medicine Xi 'an Jiaotong University Xi 'an 710061 China Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education Xi 'an Jiaotong University Xi 'an 710061 China Department of Genetics and Molecular Biology School of Medicine Xi 'an Jiaotong University Xi 'an 710061 China Department of Bone and Joint Diseases of Xi 'an Red Cross Hospital Xi 'an 710054 China Department of Forensic Medicine School of Medicine Xi 'an Jiaotong University Xi'an 710061 China

Objective： To investigate the relationships between endothelial nitric oxide synthases （eNOS） G894T and 27 bpvariable number tandem repeat （VNTR） gene polymorphisms and osteoporosis in the postmenopausal women of Chinese Han nationality. Methods： In the present study, 281 postmenopausal women from Xi＇an urban area in West China were recruited, and divided into osteoporosis, osteopenia, and normal groups according to the diagnostic criteria of osteoporosis proposed by World Health Organization （WHO）. The bone mineral density （BMD） values of lumbar vertebrae and left hips were determined by QDR-2000 dual energy X-ray absorptiometry. Blood samples were tested for plasma biochemical indicators including testosterone, estradiol, calcitonin, osteocalcin, and procollagen type I amino-terminal propeptide by enzyme-linked immunosorbent assay （ELISA）, tartrate-resistant acid phosphatase by spectrophotometric method, and the content of nitric oxide by Griess method. Genome DNA was extracted from whole blood, and G894T polymorphism of eNOS gene was analyzed by using polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） method and 27 bp-VNTR polymorphism of eNOS gene was genotyped by PCR method. Then the relationships between genotypes and biochemical indicators, genotypes and osteoporosis, and haplotypes and osteoporosis were analyzed. Results： The average BMD values of the femoral neck, ward＇s triangle and lumbar vertebrae 1-4 （LI-L4） in the subjects with T/T genotype in eNOS G894T locus were significantly higher than those in the subjects with G/T and G/G genotypes （P〈0.05）. The average BMD of the femoral neck in the subjects with a/a genotype of eNOS 27 bp-VNTR locus was evidently higher than that in the subjects with b/b genotype （P〈0.05）. The plasma testosterone and osteocalcin concentrations in the subjects of eNOS G894T G/T genotype were evidently higher than those in the subjects of other genotypes （P〈0.05）; the plasma estradiol concentration in

关键词： postmenopausal women Osteoporosis Endothelial nitric oxide synthase Gene polymorphisms Bone mineral density

Adjuvant tamoxifen switched to exemestane treatment in postmenopausal women with estrogen receptor-positive early breast cancer:A pragmatic,multicenter,and prospective clinical trial in China

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Chinese Journal of Cancer Research 2022年第6期34卷 592-600页

作者： Binghe Xu Huiping Li Zefei Jiang Lin Gu Jinhai Tang Hui Xie Yueyin Pan Yunjiang Liu Shude Cui Xiaojia Wang Li Cai Yiqiong Zhang Huadong Zhao Zhimin Shao Department of Medical Oncology National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Breast OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Department of Breast Cancer the Fifth Medical Center of Chinese PLA General HospitalBeijing 100071China Department of Breast Cancer Tianjin Cancer Institute and HospitalTianjin 300060China Department of Breast Cancer Jiangsu Provincial HospitalNanjing 210029China Department of Breast Cancer the First Affliated Hospital of China University of Science and TechnologyHefei 230001China Department of Breast Cancer the Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011China Department of Breast Cancer Henan Cancer HospitalZhengzhou 450008China Department of Breast Cancer Zhejiang Cancer HospitalHangzhou 310012China Department of Breast Cancer Harbin Medical University Cancer HospitalHarbin 150081China Department of Clinical Development Pfizer(China)R&D Co.LtdShanghai 201203China Department of Statistics Pfizer(China)R&D Co.LtdShanghai 201203China Department of Breast Surgery Shanghai Cancer Center/Cancer InstituteShanghai Medical CollegeFudan UniversityShanghai 200032China

Objective:This post-approval safety study assessed the efficacy and safety of exemestane after 2-3 years of tamoxifen treatment among postmenopausal women with estrogen receptor-positive(ER+)early breast cancer in ***:Enrolled patients had received 2-3 years of tamoxifen and were then switched to exemestane for completion of 5 consecutive years of adjuvant endocrine *** primary endpoint was the time from enrollment to the first occurrence of locoregional/distant recurrence of the primary breast cancer,appearance of a second primary or contralateral breast cancer,or death due to any *** endpoints included the proportion of patients experiencing each event,incidence rate per annum,relationships between human epidermal growth factor receptor 2 status and time to event,and relationship between disease history variables and time to ***:Overall,558 patients were included in the full analysis set:397(71.1%)completed the study,20experienced an event,and 141 discontinued[47 owing to an adverse event(AE);37 no longer willing to participate].Median duration of treatment was 29.5(range,0.1-57.7)*** time to event was not *** survival probability at 36 months was 91.4%(95%CI,87.7%-95.1%).The event incidence over the total exposure time of exemestane therapy was 3.5 events/100 person-years(20/565).Multivariate analysis showed an association between tumor,lymph node,and metastasis stage at initial diagnosis and time to event[hazard ratio:1.532(95%CI,1.129-2.080);P=0.006].Most AEs were grade 1 or 2 in severity,with arthralgia(7.7%)being the most common treatment-related ***:This study supports the efficacy and safety of exemestane in postmenopausal Chinese women with ER+breast cancer previously treated with adjuvant tamoxifen for 2-3 *** new safety signals were identified in the Chinese population.

关键词： Chinese early breast cancer exemestane tamoxifen postmenopausal women estrogen receptor-positive

Association of the MTHFR C677T polymorphism and bone mineral density in postmenopausal women:a meta-analysis

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The Journal of Biomedical Research 2010年第6期24卷 417-423页

作者： Donghua Li,Jie Wu Department of Obstetrics and Gynecology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,Jiangsu Province,China Department of Obstetrics and Gynecology the First Affiliated Hospital of Nanjing Medical University Nanjing 210029 Jiangsu Province China.

Osteoporosis is a condition characterized by low bone mineral density （BMD） and micro-architectural changes in the bone *** risk of osteoporosis is partly determined by genetic *** role of C677T polymorphism of methylenetetrahydrofolate reductase （MTHFR） gene has been investigated in postmenopausal ***,the relationship between MTHFR polymorphism and BMD is still *** carried out a meta-analysis of 5,833 subjects to evaluate the association of MTHFR and BMD in postmenopausal *** of MEDLINE,Web of Science,Scopus and CNKI were retrieved for all publications relating to MTHFR polymorphism and BMD in postmenopausal *** eligible studies were selected for *** these articles studied the association of MTHFR polymorphism and BMD of the femoral neck and lumbar spine in postmenopausal *** analysis suggested that postmenopausal women with the TT genotype had lower femoral neck BMD than the women with the CC/CT genotype,and the weighted mean difference （WMD） was-0.01 g/cm 2 [95% confidence interval （CI）：（-0.01,-0.01）,P 0.01].However,BMD of the lumbar spine of postmenopausal women with the TT genotype was not significantly different from that of women with the CC/CT *** the random effects model,the WMD between the TT and TC/CC genotype was-0.01 g/cm 2 [95% CI：（-0.04,0.01）,P=0.32].The C677T polymorphism of the MTHFR gene is associated with BMD of the femoral neck in postmenopausal *** with the TT genotype of the MTHFR gene have lower BMD,suggesting that the TT genotype may be a risk factor for postmenopausal osteoporosis.

关键词： methylenetetrahydrofolate reductase postmenopausal women bone mineral density meta-analysis

Effects of Aerobic Exercise on Atherosclerotic Risk in postmenopausal women

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Journal of Science in Sport and Exercise 2019年第2期1卷 132-141页

作者： Mengting Luo Peizhen Zhang Xinglong Zhou Xin Zhang Wei Zhao Yuming Bai School of Sport Medicine and Rehabilitation Beijing Sport UniversityNo.48 Xinxi RoadHaidian districtBeijing 100084People’s Republic of China College of Exercise Medicine Chongqing Medical UniversityChongqingPeople’s Republic of China Sport Science College Beijing Sport UniversityBeijingPeople’s Republic of China

Introduction To study the effects of aerobic exercise on lipid metabolism,endothelial function,and oxidative stress reaction in postmenopausal women,in order to prevent and control *** Thirty-two women with natural menopause were randomly divided into an exercise group and a control *** in the exercise group(n=16)took part in a 3-month aerobic training program according to their exercise pre-scription,while participants in the control group(n=16)maintained their usual ***,endothelial function,and oxidative stress-related indicators were measured before and after the *** After 3 months of aerobic training at an intensity of 50-60%of cardiorespiratory fitness,serum total cholesterol and low-density lipoprotein cholesterol decreased significantly(Ppostmenopausal *** Aerobic exercise had a positive effect on blood lipids,endothelial function,and oxidative stress of postmeno-pausal women,and these changes may mitigate the risk of atherosclerosis *** exercise programs could be used as a primary atherosclerosis prevention strategy for postmenopausal women.

关键词： Aerobic exercise postmenopausal women Atherosclerosis Endothelial function Oxidative stress

Do peripartum and postmenopausal women with primary liver cancer have a worse prognosis? A nationwide cohort in Taiwan

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World Journal of Hepatology 2021年第11期13卷 1766-1776页

作者： Guan-Woei Tseng Mei-Chen Lin Shih-Wei Lai Cheng-Yuan Peng Po-Heng Chuang Wen-Pang Su Jung-TaKao Hsueh-Chou Lai Department of Medicine China Medical UniversityTaichung 40402Taiwan Management Office for Health Data China Medical University HospitalTaichung 404Taiwan Department of Family Medicine China Medical University HospitalTaichung 404Taiwan Center for Digestive Disease Department of Internal Medicine China Medical University HospitalTaichung 404Taiwan School of Chinese Medicine China Medical UniversityTaichung 404Taiwan

BACKGROUND While primary liver cancer(PLC)is one of the most common cancers around the world,few large-scale population-based studies have been reported that evaluated the clinical survival outcomes among peripartum and postmenopausal women with *** To investigate whether peripartum and postmenopausal women with PLC have lower overall survival rates compared with women who were not peripartum and *** The Taiwan National Health Insurance claims data from 2000 to 2012 was used for this propensity-score-matched study.A cohort of 40 peripartum women with PLC and a reference cohort of 160 women without peripartum were *** the women with PLC with/without menopause study,a study cohort of 10752 menopausal females with PLC and a comparison cohort of 2688 women without menopause were *** Patients with peripartum PLC had a non-significant risk of death compared with the non-peripartum cohort[adjusted hazard ratios(aHR)=1.40,95%confidence intervals(CI):0.89-2.20,P=0.149].The survival rate at different follow-up durations between peripartum PLC patients and those in the non-peripartum cohort showed a non-significant *** who were diagnosed with PLC younger than 50 years old(without menopause)had a significant lower risk of death compared with patients diagnosed with PLC at or older than 50 years(postmenopausal)(aHR=0.64,95%CI:0.61-0.68,Pwomenwomen with PLC when followed for 0.5(72.44%vs 64.16%),1(60.57%vs 51.66%),3(42.92%vs 31.28%),and 5 year(s)(37.02%vs 21.83%),respectively(P<0.001).CONCLUSION Peripartum females with PLC have no difference in survival rates compared with those patients without *** females with PLC have worse survival rates compared with those patients without menopause.

关键词： Primary liver cancer Peripartum and postmenopausal women Prognosis Nationwide cohort Peripartum women postmenopausal women

Effects of vibration therapy on bone mineral density in postmenopausal women with osteoporosis

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Chinese Medical Journal 2008年第13期121卷 1155-1158页

作者： RUAN Xiang-yan JIN Feng-yu LIU Yu-lan PENG Zhou-li SUN Yun-gao Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing 100026 China

Background Jaw osteonecrosis possibly associated with the administration of bisphosphonates is expected to be treated with a non-pharmacologic approach. This study aimed to determine whether noninvasive, mechanically mediated vibration would inhibit the decline in bone mineral density （BMD） that follows menopause, enhance the BMD of the lumbar and femoral neck, and reduce chronic back pain in postmenopausal women with osteoporosis. Methods A total of 116 postmenopausal women with osteoporosis participated in this study, and they were divided into groups A （66 patients） and B （50）. Group A received vibration treatment （Subjects vertically stand on the vibration platform, with a vibration frequency of 30 Hz, amplitude of 5 mm; they received the treatment five times per week, ten minutes each time and totally for six months）, whereas women of group B served as controls without any treatment. L2-4 BMD, bilateral femoral neck BMD, and body mass index （BMI） were recorded before the treatment or at the third and sixth months of the treatment respectively. After the ending of the treatment, the change of BMD in each group was compared and analyzed. Chronic back pain was evaluated by visual analogue scale （VAS） at baseline and the third and sixth months of the treatment. Results Of the 116 women, 94 including 51 women from group A （（61.23±8.20） years） and 43 women from group B （（63.73±5.45） years）, completed the study. There were no significant differences in baseline characteristics including age, BMI, menopausal years, lumbar BMD, femoral neck BMD, and VAS between the two groups. The lumbar BMD of the 51 women in group A increased by 1.3% （P=0.034） after vibration treatment for 3 months and by 4.3% at the sixth month （P=0.000）. The lumbar BMD in group B was decreased at the third month, but there was not statistical significance （P〉0.05） At the sixth month, it was decreased by 1.9% （P 〈0.05）. The femoral neck BMD of the 51 women in group A was slightly increased after

关键词： postmenopausal women vibration treatment osteoporosis bone mineral density

Association between serum resistin level and cardiovascular events in postmenopausal women with acute coronary syndrome undergoing percutaneous coronary intervention

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Chinese Medical Journal 2013年第6期126卷 1058-1062页

作者： LI Lei HAN Jiang-li MAO Jie-ming GUO Li-jun GAO Wei Department of Cardiology Peking University Third Hospital Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Ministry of Health Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education Beijing 100191 China

Background As an adipocytokine, resistin has been proposed as a link between inflammation, metabolic disorder and atherosclerosis. The aim of the study is to evaluate whether serum resistin is associated with acute coronary syndrome （ACS） and major adverse cardiovascular events （MACEs） among postmenopausal women with ACS undergoing percutaneous coronary intervention （PCI）. Methods A total of 106 consecutive postmenopausal women who underwent coronary angiography for evaluation of suspected myocardial ischemia were enrolled. Pre-procedure serum resistin, inflammatory and metabolic biomarkers were measured. All participants were followed for seven years for MACEs, including cardiovascular death, recurrent nonfatal myocardial infarction, and re-PCl. Results Patients with ACS （n=69） had significantly higher resistin levels than those without coronary artery disease （CAD）（n=37）（4.61 （1.79-10.80） ng/ml vs. 2.36 （0.85-4.15） ng/ml, P=0.002）. Correlation analysis revealed positive correlations between resistin levels and inflammatory and metabolic factors （P 〈0.05）. A follow-up of a mean of 83.4 months showed that patients with ACS suffered more MACEs than those without （13.0% vs. 2.7%, P=0.05）. Adjusted for cardiovascular risks, inflammatory and metabolic factors, multiple Logistic regression analysis indicated that an elevated resistin level was an independent predictor of ACS onset （OR=1.139, 95% CI 1.024-1.268, P=0.017） and of MACEs after PCI （OR=1.099, 95% CI 1.015-1.189, P=-0.019）. To clarify the association between resistin levels and MACEs, ACS patients were divided into two subgroups on the basis of resistin levels. Compared with the low resistin subgroup （≤4.35 ng/ml, n=32）, patients in the high resistin subgroup （〉4.35 ng/ml, n=37） were more prone to suffer MACEs （21.6% vs. 3.1%, P=0.015）. Kaplan-Meier analysis showed a significantly lower event-free survival rate in ACS patients with high resistin levels than in the low resistin subgroup （78.4% vs. 96.9%, Log r

关键词： postmenopausal women resistin acute coronary syndrome major adverse cardiovascular events

The relationship between sex hormones and extent of coronary artery disease in postmenopausal women

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Chinese Medical Journal 2007年第1期120卷 71-73页

作者： Odgerel Tumur HAN Jiang-li YANG Chi-sun MAO Jie-ming Department of Cardiology Peking University Third HospitalBeijing 100083 China Department of Obstetrics and Gynaecology Peking UniversityThird Hospital Beijing 100083 China

The prevalence of coronary artery disease （CAD） in women increases with menopause. Results from the studies on the role of endogenous sex hormones on CAD in postmenopausal women are conflicting. The present study evaluated the relationship between endogenous sex hormones and extent of CAD in postmenopausal women and the associations of sex hormones with CAD risk factors.

关键词： sex hormones coronary artery disease postmenopausal women