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Effects of varying dietary folic acid during weaning stress of piglets

Animal Nutrition 2021年第1期7卷 101-110页

作者： Lei Wang Xian Tan Huiru Wang Qiye Wang Pengfei Huang Yali Li Jianzhong Li Jing Huang Huansheng Yang Yulong Yin Laboratory of Animal Nutrition and Human Health Hunan International Joint Laboratory of Animal Intestinal Ecology and HealthCollege of Life ScienceHunan Normal UniversityChangsha410081China Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionKey Laboratory of Agro-ecological Processes in Subtropical RegionScientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-CentralMinistry of AgricultureInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha410125China Department of Neuroscience Hengyang School of MedicineUniversity of South ChinaHengyang421000China

The present study was conducted to evaluate the effect of dietary folic acid on the growth performance,intestinal morphology,and intestinal epithelial cells renewal in post-weaning ***-eight piglets(weaned at day 21,initial body weight of 6.73±0.62 kg)were randomly allotted to 4 treat-ments with 7 pens per diet and 1 piglet per *** piglets were fed the same antibiotic-free and zinc oxide-free basal diets supplemented with folic acid at 0,3,9,and 18 mg/kg for 14 *** results showed that dietary supplementation with folic acid increased villus height(VH)(P=0.003;linear,P=0.001),VH-to-crypt depth(VH:CD)ratio(P=0.002;linear,P=0.001),villus surface area(VSA)(P=0.026;linear,P=0.010).The analyzed parameters ADG,serum urea nitrogen(BUN)content,VH,VSA,and serum folate(SF)concentration responded linearly to the dietary folic acid concentration when the dietary folic acid concentration was below 4.42,5.26,4.79,3.47,and 3.53 mg/kg respectively(R2=0.995,0.995,0.999,0.999,0.872,P=0.09,0.07,0.09,0.09,0.36,respectively),as assessed by a two-linear broken-line *** these breakpoints,the response of ADG,VH,VSA,and SF plateaued in response to changes in dietary folic acid ***,dietary supplementation with folic acid significantly increased the lactase(P=0.001;linear,P=0.001)and sucrase activities(P=0.021;linear,P=0.010)in the jejunal mucosa of weaned *** mRNA expression of solute carrier family 6 member 19(SLC6a19),solute carrier family 1 member 1(SLC7a1),tumor necrosis factor-α(TNF-α),the number of Ki67 positive cells,and cell shedding rate had a significant linear contrast(P=0.023,0.021,0.038,0.049,and 0.008,respectively)in dietary folic acid *** conclusion,our results indicate that folic acid supplementation can improve the growth performance and intestinal morphology of weaned piglets by maintaining the balance of epithelial cell renewal.

关键词： Folic acid Growth performance Antibiotic-free Intestinal morphology post-weaning piglet

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Lower abundance of Bacteroides and metabolic dysfunction are highly associated with the post-weaning diarrhea in piglets

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Science China(Life Sciences) 2022年第10期65卷 2062-2075页

作者： Wen Ren Bing Yu Jie Yu Ping Zheng Zhiqing Huang Junqiu Luo Xiangbing Mao Jun He Hui Yan Jinlong Wu Daiwen Chen Yuheng Luo Key Laboratory for Animal Disease-Resistance Nutrition of Ministry of Education of China Key Laboratory for Animal Disease-Resistance Nutrition and Feed of Ministry of Agriculture of ChinaKey Laboratory of Animal Disease-resistant Nutrition of Sichuan Provinceand Animal Nutrition InstituteSichuan Agricultural UniversityChengdu61l130China DSM(China)Animal Nutrition Research Center Co. LtdBazhou 065799China

Growing evidences show a direct link between diarrhea and disorders of gut microbiota in ***,whether there are microbial markers associated with post-weaning diarrhea remains *** the current study,we compared the microbial community,functions and metabolites between healthy weaned piglets(group H,n=7)and piglets with post-weaning diarrhea(group D,n=7),in order to find out diarrhea associated microbial *** of 7 fecal samples was collected from H and D piglets(weaned at 21 d and sampled at 26 d).The metagenomic and untargeted metabolomic analysis revealed that the microbial composition,function and metabolic profile in D pigs was considerably reshaped,including the reduced abundance and number of Bacteroides,which significantly correlated with the diarrhea status of *** carbohydrate metabolism,biosynthesis and metabolism,lipid metabolism,amino acid metabolism,and the activity of glycan and carbohydrates digestion related enzymes showed extensively down-regulated in D pigs compared with H *** significantly changed the metabolic profiles of fecal microbiota,and most of the altered metabolites were negatively or positively correlated with the change in the abundance of *** conclusion,the lower abundance of Bacteroides and its associated metabolic dysfunction may be regarded as microbial markers of physiological post-weaning diarrhea in piglets.

关键词： post-weaning piglet diarrhea Bacteroides metabolic dysfunction commensal microbiota

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Investigation of the Relationship Between SLA-1 and SLA-3 Gene Expression and Susceptibility to Escherichia Coli F18 in post-weaning Pigs

Investigation of the Relationship Between SLA-1 and SLA-3 Ge...

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第五届中国畜牧科技论坛

作者： L.Ye C.Zi X.M.Su Z.C.Wu G.Q.Zhu S.L.Wu J.Y.Wang College ofAnimal Science and Technology Yangzhou University College of Veterinary Medicine Yangzhou University Yangzhou Public Technical Service Center for Large-scale High Efficient and Healthy Breeding of Pig Suzhou Taihu Pig Breeding Center

Porcine post-weaning diarrhea and edema disease are principally caused by *** strains that produce F18 ***1 genotyping and receptor binding studies divided piglets into *** F18-resistant and -sensitive groups,and the roles of SLA-1 and SLA-3 were ***-1 and SLA-3 expression was detected in 11 pig tissues,with higher levels of SLA-1 in lung,immune tissues and gastrointestinal tract,and higher levels of SLA-3 also in lung and lymphoid *** genes were expressed higher in F18-resistant piglets,and their expression was positively correlated in different tissues;a negative correlation was observed in some tissues of F18-sensitive group,particularly in lung and lymphatic *** ontology and pathway analyses showed that SLA-1 and SLA-3 were involved in 37 biological processes,including nine pathways related to immune *** observations help to elucidate the relationship between SLA class I genes and E. coli F18-related porcine gastrointestinal tract diseases.

关键词： Escherichia coli F18 post-weaning piglet SLA-1 SLA-3.

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