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Autophagy in the pathogenesis and therapeutic potential of post-traumatic osteoarthritis

Burns & Trauma 2023年第1期11卷 155-175页

作者： Yunquan Gong Song Li Jinghui Wu Tongyi Zhang Shunzheng Fang Daibo Feng Xiaoqing Luo Jing Yuan Yaran Wu Xiaojing Yan Yan Zhang Jun Zhu Jiangyi Wu Jiqin Lian Wei Xiang Zhenhong Ni State Key Laboratory of Trauma Burns and Combined InjuryDepartment of Rehabilitation MedicineDaping HospitalArmy Medical UniversityChangjiang StreetYuzhong DistrictChongqing 400042China Department of Orthopedics Shanghai HospitalShanghai StreetWanzhou DistrictChongqing 404000China Department of Wound Repair and Rehabilitation Medicine Center of Bone Metabolism and RepairLaboratory for Prevention and Rehabilitation of Training InjuriesState Key Laboratory of TraumaBurns and Combined InjuryTrauma CenterResearch Institute of SurgeryDaping HospitalArmy Medical UniversityChangjiang StreetYuzhong DistrictChongqing 400042China Joint Surgery and Sport Medicine Department Hunan Provincial People’s Hospitalthe First Affiliated Hospital of Hunan Normal UniversityJiefangxi StreetFurong DistrictChangsha 410005China Department of General practice Chinese PLA General Hospital of the Central Theater CommandWuluo StreetWuchang DistrictWuhan 430000China Department of Biochemistry and Molecular Biology College of Basic Medical SciencesArmy Medical UniversityGantaoyan StreetShapinba DistrictChongqing 400038China Department of Clinical Biochemistry Faculty of Pharmacy and Laboratory MedicineArmy Medical UniversityGantaoyan StreetShapinba DistrictChongqing 400038China Department of Pediatrics People’s Hospital Affiliated to Chongqing Three Gorges Medical CollegeGuoben StreetWanzhou districtChongqing 404000China Department of Cardiology Shanghai HospitalShanghai StreetWanzhou DistrictChongqing 404000China Department of Sports Medicine and Rehabilitation Shenzhen HospitalPeking UniversityLianhua StreetFutian DistrictShenzhen 518034China

Autophagy,as a fundamental mechanism for cellular homeostasis,is generally involved in the occurrence and progression of various ***(OA)is the most common muscu-loskeletal disease that often leads to pain,disability and economic loss in ***-traumatic OA(PTOA)is a subtype of OA,accounting for>12%of the overall burden of *** is often caused by joint injuries including anterior cruciate ligament rupture,meniscus tear and intra-articular *** a variety of methods have been developed to treat acute joint injury,the current measures have limited success in effectively reducing the incidence and delaying the progression of ***,the pathogenesis and intervention strategy of PTOA need further *** the past decade,the roles and mechanisms of autophagy in PTOA have aroused great interest in the *** was revealed that autophagy could maintain the homeostasis of chondrocytes,reduce joint inflammatory level,prevent chondrocyte death and matrix degradation,which accordingly improved joint symptoms and delayed the progression of ***,many strategies that target PTOA have been revealed to promote *** this review,we summarize the roles and mechanisms of autophagy in PTOA and the current strategies for PTOA treatment that depend on autophagy regulation,which may be beneficial for PTOA patients in the future.

关键词： Autophagy post-traumatic osteoarthritis mTOR Noncoding RNAs

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Initial effects of inflammation-related cytokines and signaling pathways on the pathogenesis of post-traumatic osteoarthritis

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Frontiers of Nursing 2018年第2期5卷 91-96页

作者： Peng-Fei Han Zhi-Liang Zhang Tao-Yu Chen Rui-Peng Zhao Rong Zhang Xiao-Dong Li Peng-Cui Li Lei Wei Zhi Lv Xiao-Chun Wei Second People's Hospital of Changzhi City ChangzhiShanxi 046010China Second Affiliated Hospital of Shanxi Medical University TaiyuanShanxi 030001China Affiliated Peace Hospital of Changzhi Medical College ChangzhiShanxi 046010China

The main pathological change in post-traumatic osteoarthritis （PTOA） is cartilage degeneration, which is closely related to inflammation and oxidative stress. Inflammation can cause degeneration of articular cartilage. Cartilage degeneration can also stimulate the progression of inflammation. It has been found that inflammatory cytokines can participate in the pathological process of cartilage degeneration through multiple signaling pathways, mainly mitogen-activated protein kinase, nuclear transcription factor kappa B, and Wnt-p-catenin signal transduction pathways. This review aimed at exploring the relationship between PTOA and inflammation-related cytokines by introducing the role of proinflammatory cytokines in chondrocyte destruction and extracellular matrix degradation.

关键词： post-traumatic osteoarthritis cartilage degeneration pminflammatory cytokine signaling pathway

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Distraction arthroplasty in osteoarthritis of the foot and ankle

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World Journal of Orthopedics 2020年第3期11卷 145-157页

作者： Sherif Dabash Joshua R Buksbaum Austin Fragomen S Robert Rozbruch Limb Lengthening and Complex Reconstruction Service Weill Cornell Medical College Department of Orthopaedic SurgeryHospital for Special Surgery New YorkNY 10021United States SUNY Downstate Health Sciences University College of MedicineBrooklynNew YorkNY 11226United States

post-traumatic osteoarthritis(PTOA)is a complex and painful problem in the foot and *** percent of osteoarthritis cases in the foot and ankle can be classified as *** can affect any of the 33 joints in the foot and the *** arthroplasty is a method for treatment of early arthritic joints without fusing or replacing them and its effectiveness has been well *** purpose of this case series is to present our successful experiences and positive results using distraction arthroplasty to treat PTOA in the ankle,subtalar,first metatarsophalangeal,and second tarsometatarsal joints,and to present distraction arthroplasty as a viable alternative to invasive joint sacrificing procedures such as arthrodesis or *** Arthroplasty effectively and safely treats PTOA and improves the stability of joints in the Foot and ***,the use of bone marrow aspirate concentrate as an adjuvant can improve the long-term functional and structural outcomes of the joint,and can prolong the need for further,more aggressive surgical interventions such as fusion or arthroplasty.

关键词： Distraction arthroplasty First metatarso-phalangeal joint arthritis Second tarsometarsal joint arthritis Ankle arthritis Subtalar arthritis post-traumatic osteoarthritis

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