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Overexpression of brain-derived neurotrophic factor in the hippocampus protects against post-stroke depression

Neural Regeneration Research 2015年第9期10卷 1427-1432页

作者： Hao-hao Chen Ning Zhang Wei-yun Li Ma-rong Fang Hui Zhang Yuan-shu Fang Ming-xing Ding Xiao-yan Fu Medical Molecular Biology Laboratory School of Medicine Jinhua Polytechnic Institute of Neuroscience School of Medicine Zhejiang University Center of Experimental Animals Jinhua Food and Drug Administration

post-stroke depression is associated with reduced expression of brain-derived neurotrophic factor （BDNF）. In this study, we evaluated whether BDNF overexpression affects depression-like behavior in a rat model of post-stroke depression. The middle cerebral artery was occluded to produce a model of focal cerebral ischemia. These rats were then subjected to isolation-housing combined with chronic unpredictable mild stress to generate a model of post-stroke depression. A BDNF gene lentiviral vector was injected into the hippocampus. At 7 days after injection, western blot assay and real-time quantitative PCR revealed that BDNF expression in the hippo- campus was increased in depressive rats injected with BDNF lentivirus compared with depressive rats injected with control vector. Furthermore, sucrose solution consumption was higher, and horizontal and vertical movement scores were increased in the open field test in these rats as well. These findings suggest that BDNF overexpression in the hippocampus of post-stroke depressive rats alleviates depression-like behaviors.

关键词： nerve regeneration brain injury brain-derived neurotrophic factor lentivirus post-strokedepression depression-like behavior hippocampus cerebral ischemia sucrose solution consumption open field test chronic unpredictable mild stress western blot assay neural regeneration

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