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Clinical Report on the Treatment of post-stroke cognitive impairment Based on Microbe-Gut-Brain Axis Theory

Medicinal Plant 2022年第2期13卷 70-72,86页

作者： Zhonghui ZENG Lingyun ZHOU Zeyu ZHANG Guizhou University of Traditional Chinese Medicine Guiyang 550002 China Cadre Health Care Department The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine Guiyang 550003 China

Based on the close relationship between MGBA and PSCI,one PSCI related case is reported,and it is emphasized to improve clinicians'understanding of MGBA theory in the treatment of PSCI,thereby providing new ideas for ... 详细信息

关键词： Microbe-gut-brain axis post-stroke cognitive impairment Gut microbe

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Relationship between β-amyloid protein 1-42, thyroid hormone levels and the risk of cognitive impairment after ischemic stroke

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World Journal of Clinical Cases 2020年第1期8卷 76-87页

作者： Lei Mao Xiao-Han Chen Jian-Hua Zhuang Peng Li Yi-Xin Xu Yu-Chen Zhao Yue-Jin Ma Bin He You Yin Department of Neurology Changzheng Hospitalthe PLA Naval Medical UniversityShanghai 200003China Department of Neurology Shanghai First People’s Hospital Baoshan BranchShanghai 200003China

BACKGROUND post-stroke cognitive impairment(PSCI)is not only a common consequence of stroke but also an important factor for adverse prognosis of patients.Biochemical indicators such as blood lipids and blood pressure are affected by many factors,and the ability of evaluating the progress of patients with PSCI is insufficient.Therefore,it is necessary to find sensitive markers for predicting the progress of patients and avoiding PSCI.Recent studies have shown thatβ-amyloid protein 1-42(Aβ1-42)and thyroid hormone levels are closely related to PSCI,which may be the influencing factors of PSCI,but there are few related studies.AIM To investigate the relationship between serum levels of Aβand thyroid hormones in acute stage and PSCI and its predicted value.METHODS A total of 195 patients with acute cerebral infarction confirmed from June 2016 to January 2018 were enrolled in this study.Baseline data and serological indicators were recorded to assess cognitive function of patients.All patients were followed up for 1 year.Their cognitive functions were evaluated within 1 wk,3 mo,6 mo and 1 yr after stroke.At the end of follow-up,the patients were divided into PSCI and non-PSCI according to Montreal cognitive assessment score,and the relationship between biochemical indexes and the progression of PSCI was explored.RESULTS Compared with patients with non-PSCI,the levels of Aβ1-42,triiodothyronine(T3)and free thyroxin were lower in the patients with PSCI.Repeated measures analysis of variance showed that the overall content of Aβ1-42 and T3 in PSCI was also lower than that of the non-PSCI patients.Further analysis revealed that Aβ1-42(r=0.348),T3(r=0.273)and free thyroxin(r=0.214)were positively correlated with disease progression(P<0.05),suggesting that these indicators have the potential to predict disease progression and outcome.Cox regression analysis showed that Aβ1-42 and T3 were important factors of PSCI.Then stratified analysis showed that the lower the Aβ1-42 and T3,the higher risk of PSCI in patients who were ag

关键词： post-stroke cognitive impairment Triiodothyronine β-amyloid protein Prognosis Montreal cognitive assessment Free thyroxin

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P25/CDK5-mediated Tau Hyperphosphorylation in Both Ipsilateral and Contralateral Cerebra Contributes to cognitive Deficits in post-stroke Mice

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Current Medical Science 2023年第6期43卷 1084-1095页

作者： Jing YU Yang ZHAO Xiao-kang GONG Zheng LIANG Yan-na ZHAO Xin LI Yu-ju CHEN You-hua YANG Meng-juan WU Xiao-chuan WANG Xi-ji SHU Jian BAO Institute of Biomedical Sciences School of MedicineJianghan UniversityWuhan430056China Department of Pathology and Pathophysiology School of MedicineJianghan UniversityWuhan430056China Department of Pathophysiology School of Basic MedicineKey Laboratory of Education Ministry of China for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective post-stroke cognitive impairment(PSCI)develops in approximately one-third of stroke survivors and is associated with ingravescence.Nonetheless,the biochemical mechanisms underlying PSCI remain unclear.The study aimed to establish an ischemic mouse model by means of transient unilateral middle cerebral artery occlusions(MCAOs)and to explore the biochemical mechanisms of p25/cyclin-dependent kinase 5(CDK5)-mediated tau hyperphosphorylation on the PSCI behavior.Methods cognitive behavior was investigated,followed by the detection of tau hyperphosphorylation,mobilization,activation of kinases and/or inhibition of phosphatases in the lateral and contralateral cerebrum of mice following ischemia in MACO mice.Finally,we treated HEK293/tau cells with oxygen-glucose deprivation(OGD)and a CDK5 inhibitor(Roscovitine)or a GSK3βinhibitor(LiCl)to the roles of CDK5 and GSK3βin mediating ischemia-reperfusion-induced tau phosphorylation.Results Ischemia induced cognitive impairments within 2 months,as well as causing tau hyperphosphorylation and its localization to neuronal somata in both ipsilateral and contralateral cerebra.Furthermore,p25 that promotes CDK5 hyperactivation had significantly higher expression in the mice with MCAO than in the shamoperation(control)group,while the expression levels of protein phosphatase 2(PP2A)and the phosphorylation level at Tyr307 were comparable between the two groups.In addition,the CDK5 inhibitor rescued tau from hyperphosphorylation induced by OGD.Conclusion These findings demonstrate that upregulation of CDK5 mediates tau hyperphosphorylation and localization in both ipsilateral and contralateral cerebra,contributing to the pathogenesis of PSCI.

关键词： cyclin-dependent kinase 5 p25 post-stroke cognitive impairment tau hyperphosphorylation

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基于“四海理论”组穴针刺治疗脑卒中后认知障碍的临床观察

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World Journal of Acupuncture-Moxibustion 2022年第4期32卷 324-328页

作者：杨金华朱永磊韩冰杨龙六安市中医院康复二科安徽六安237005

Objective:To observe the clinical effect on post-stroke cognitive impairment(PSCI) treated by acupuncture at the acupoints composed in accordance with the "four seas theory".Methods:A total of 70 patients with PSCI were randomly divided into a treatment group(n=35) and a control group(n=35).In the control group,conventional basic treatment and rehabilitation training were adopted,while in the treatment group,on the base of the treatment as the control group,acupuncture was applied at the acupoints composed in accordance with "four seas theory",lasting 8 weeks.The scores of mini-mental state examination(MMSE) and the instantaneous memory,the scores of Montreal cognitive assessment(MoCA) and the delayed memory,the score of kidney essence insufficiency in syndrome differentiation scale of vascular dementia(SDSVD),event-related potentials(ERP) P300 and clinical therapeutic effect were compared in the patients between two groups before and after treatment separately.Results:After treatment,MMSE score and the score of instantaneous memory were higher than the results before treatment in either group respectively(all P 0.05).However,in the treatment group,P300 latency was reduced and the wave amplitude was increased after treatment(both P <0.05).The total effective rate was 88.57% in the treatment group,higher than 71.43% in the control group(P <0.05).Conclusion:Acupuncture at the acupo

关键词： post-stroke cognitive impairment Acupuncture Four seas theory

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