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Therapeutic Effects of Shenfu Injection(参附注射液) on post-cardiac arrest syndrome

Chinese Journal of Integrative Medicine 2013年第9期19卷 716-720页

作者：郭志军李春盛 Emergency Department of Beijing Chaoyang Hospital Capital Medical University

Survival rates after cardiac arrest have not changed substantially over the past 5 decades. post- cardiac arrest （CA） syndrome （PCAS） is the primary reason for the high mortality rate after successful restoration of spontaneous circulation （ROSC）. Intravenous administration of Shenfu Injection （参附注射液, SFI） may attenuate post-CA myocardial dysfunction and cerebral injury, inhibit systemic ischemiaJreperfusion responses, and treat underlying diseases. In this article, we reviewed the therapeutic effects of SFI in PCAS. SFI might be useful in the treatment of PCAS, incorporating the multi-link and muff-target advantages of Chinese medicine into PCAS management. Further experimental and clinical research to verify the therapeutic effects of SFI in PCAS is required.

关键词： cardiac arrest post-cardiac arrest syndrome Chinese medicine Shenfu Injection

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Neuronal injury and tumor necrosis factor-alpha immunoreactivity in the rat hippocampus in the early period of asphyxia-induced cardiac arrest under normothermia

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Neural Regeneration Research 2017年第12期12卷 2007-2013页

作者： Hyun-Jin Tae Il Jun Kang Tae-Kyeong Lee Jeong Hwi Cho Jae-Chul Lee Myoung Cheol Shin Yoon Sung Kim Jun Hwi Cho Jong-Dai Kim Ji Hyeon Ahn Joon Ha Park In-Shik Kim Hyang-Ah Lee Yang Hee Kim Moo-Ho Won Young Joo Lee Bio-Safety Research Institute College of Veterinary Medicine Chonbuk National University Iksan South Korea Department of Food Science and Nutrition Hallym University Chuncheon South Korea Department of Neurobiology School of Medicine Kangwon National University Chuncheon South Korea Department of Emergency Medicine School of Medicine Kangwon National University Chuncheon South Korea Department of Emergency Medicine Samcheok Medical Center Samcheok South Korea Division of Food Biotechnology School of Biotechnology Kangwon National University Chuncheon South Korea Department of Biomedical Science Research Institute of Bioscience and Biotechnology Hallym University Chuncheon South Korea Department of Obstetrics and Gynecology School of Medicine Kangwon National University Chuncheon South Korea Department of Surgery School of Medicine Kangwon National University Chuncheon South Korea Department of Emergency Medicine Seoul Hospital College of Medicine Sooncheonhyang University Seoul South Korea

Low survival rate occurs in patients who initially experience a spontaneous return of circulation after cardiac arrest（CA）. In this study, we induced asphyxial CA in adult male Sprague-Daley rats, maintained their body temperature at 37 ± 0.5°C, and then observed the survival rate during the post-resuscitation phase. We examined neuronal damage in the hippocampus using cresyl violet（CV） and Fluore-Jade B（F-J B） staining, and pro-inflammatory response using ionized calcium-binding adapter molecule 1（Iba-1）, glial fibrillary acidic protein（GFAP）, and tumor necrosis factor-alpha（TNF-α） immunohistochemistry in the hippocampus after asphyxial CA in rats under normothermia. Our results show that the survival rate decreased gradually post-CA（about 63% at 6 hours, 37% at 1 day, and 8% at 2 days post-CA）. Rats were sacrificed at these points in time post-CA, and no neuronal damage was found in the hippocampus until 1 day post-CA. However, some neurons in the stratum pyramidale of the CA region in the hippocampus were dead 2 days post-CA. Iba-1 immunoreactive microglia in the CA1 region did not change until 1 day postCA, and they were activated（enlarged cell bodies with short and thicken processes） in all layers 2 days postCA. Meanwhile, GFAP-immunoreactive astrocytes did not change significantly until 2 days post-CA. TNF-α immunoreactivity decreased significantly in neurons of the stratum pyramidale in the CA1 region 6 hours post-CA, decreased gradually until 1 day post-CA, and increased significantly again 2 days post-CA. These findings suggest that low survival rate of normothermic rats in the early period of asphyxia-induced CA is related to increased TNF-α immunoreactivity, but not to neuronal damage in the hippocampal CA1 region.

关键词： nerve regeneration post-cardiac arrest syndrome normothermia neuronal damage gliosis tumor necrosis factor-alpha neural regeneration

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Influence of Microcirculatory Dysfunction on Myocardial Injury after Cardiopulmonary Resuscitation

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Biomedical and Environmental Sciences 2022年第4期35卷 334-344页

作者： YANG Jun DONG Gui Juan WANG Hong Wei ZHAO Xin WANG Fu Jun ZHANG Jian GUO Shu Bin Emergency Medicine Clinical Research Center of Beijing Chaoyang Hospital Capital Medical UniversityBeijing Key Laboratory of Cardiopulmonary Cerebral ResuscitationBeijing 100020China

Objective This study aimed to examine the effects of microcirculatory dysfunction and 654-1intervention after cardiopulmonary resuscitation on myocardial *** Landrace pigs were divided into a sham operation group(S group,n=6),ventricular fibrillation control group(VF-C group,n=8)and 654-1 intervention group(VF-I group,n=8).Hemodynamics was recorded at baseline,at recovery of spontaneous circulation(ROSC),and 1 h,2 h,4h and 6 h *** dark field(SDF)technology was used to evaluate and monitor the microcirculation flow index,total vessel density,perfusion vessel ratio,De-Backer score,and perfusion vessel density in animal viscera at various time *** After administration of 654-1 at 1.5 h post-ROSC,the hemodynamics in the VF-I group,as compared with the VF-C group,was significantly *** visceral microcirculation detected by SDF was also significantly improved in the VF-I *** observed through electron microscopy,significantly less myocardial tissue injury was present in the VF-I group than the VF-C *** Administration of 654-1 inhibited excessive inflammatory by improving the state of visceral microcirculation.

关键词： Cardiopulmonary resuscitation post-cardiac arrest syndrome Microcirculation dysfunction Myocardial injury Anisodamine hydrobromide(654-1)

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