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The possible value of ~18F-FDG positron emission tomography/computerized tomography imaging in detection of atherosclerotic plaque

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Journal of Nanjing Medical University 2008年第1期22卷 61-65页

作者： Jianwei Yuan Yanlin Feng Lingxiao Fan Xiaohong He Departrnent of Nuclear Medicine Affiliated Foshan Hospital of Sun Yat-sen University Foshan 528000 Guangdong Province China Office of Scientific Research Management zhongshan School of Medicine Sun Yat-sen University Guangzhou 510080

Objective：To evaluate the clinical value with positron emission tomography/computerized tomography（PET/CT） imaging for the detection of vulnerable plaque in atherosclerotic lesions. Methods：Sixty people with a age of over 60[mean age （69.2 ± 7.1）years] underwent three dimension（3D） whole-body fluorine-18-2-fluoro-2-deoxy-D-glucose（^18F-FDG） PET/CT imaging and were evaluated retrospectively, including 6 cases assessed as normal and 54 cases with active atherosclerotic plaque. Fifty-four cases with SUVs and CT values in the aortic wall of high-FDG-uptake were measured retrospectively. These high-FDG-uptake cases in the aortic wall were divided into three groups according their CT value. Cases in group 1 had high uptake in atherosclerotic lesions of the aortic wall with CT value of less than 60 Hu（soft plaque）. Cases in group 2 had high uptake with CT value between 60-100 Hu （intermediate plaque）, Cases in group 3 had high uptake with CT value more than 100 Hu（calcified plaque）, Group 4 was normal. Results： In group 1, there were 42 high-FDG-uptake sites （average SUV 1.553 ± 0.486）. In group 2, there were 30 high-FDG-uptake sites（average SUV 1.393 ± 0.296）. In group 3, there were 36 high-FDG-uptake sites（average SUV 1.354 ± 0.189）. In group 4, there were 33 normal-FDG-uptake sites （average SUV was 1.102 ± 0.141）, The SUVs showed significant difference among the four groups（F = 678.909, P = 0.000）. There were also significant difference found between the normal-FDG-uptake group and the high-FDG-uptake groups（P = 0.000, 0.000, 0.001, respectively）. Conclusion：Different degrees of ^18F-FDG uptake in active large atherosclerotic plaque were shown in different stages of atherosclerotic plaque formation. The soft plaque had the highest FDG uptake in this study. This suggested that ^18F- FDG PET/CT imaging may be of great potential value in early diagnosis and monitoring of vulnerable soft plaque in atherosclerotic lesions.

关键词： fluorine-18-2-fluoro-2-deoxy-D-glucose positron-emission tomography computerized, tomography atherosclerosis vulnerable plaque

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Primary hepatic neuroendocrine neoplasm diagnosed by somatostatin receptor scintigraphy:A case report

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World Journal of Clinical Cases 2022年第7期10卷 2222-2228页

作者： Miho Akabane Yuta Kobayashi Keiichi Kinowaki Satoshi Okubo Junichi Shindoh Masaji Hashimoto Division of Hepatobiliary-pancreatic Surgery Department of Gastroenterological SurgeryToranomon HospitalTokyo 105-8470Japan Department of Diagnostic Pathology Toranomon HospitalTokyo 105-8470Japan

BACKGROUND Primary hepatic neuroendocrine neoplasm(NEN)is a rare condition,and it is difficult to differentiate between primary and metastatic hepatic NENs.Herein,we report a case of primary hepatic NEN that initially mimicked a hemangioma but showed a gradual increase in size on long-term careful observation.CASE SUMMARY A 47-year-old woman was incidentally diagnosed with a 12-mm liver mass,suspected to be a hemangioma.Since then,regular follow-up had been carried out.Ten years later,she was referred to our institute due to the tumor(located in segment 4)having increased to 20 mm.Several imaging studies depicted no apparent extrahepatic lesion.positron emission tomography(PET)/computed tomography exhibited significant accumulation in the mass lesion,which made us consider the possibility of malignancy.Left hepatectomy was performed.The histopathological diagnosis was neuroendocrine tumor grade 2,with somatostatin receptor 2 a/5 positivity.Postoperative somatostatin receptor scintigraphy(SRS)showed no other site,leading to the diagnosis of NEN of primary hepatic origin.The gradual growth of the hepatic NEN over 10 years suggested that it was likely to be a primary liver tumor.CONCLUSION In this case,positivity on PET and postoperative SRS may have helped determine whether the tumor was primary or metastatic.

关键词： Hepatic neoplasm Scintigraphy Surgery positron-emission tomography Clinical decision-making Case report

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An unusual case of right-sided colon cancer with isolated lateral pelvic side wall lymph node metastases

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Laparoscopic, Endoscopic and Robotic Surgery 2022年第3期5卷 121-123页

作者： Rishaan Pawaskar James Wei Tatt Toh Discipline of Surgery Faculty of Medicine and HealthThe University of SydneySydneyNSW2145Australia Department of Colorectal Surgery Westmead HospitalSydneyNSW2145Australia

Lymphatic drainage is typically in the direction of arterial supply,and lymphatic drainage for right-sided colon cancers typically travels to ileocolic lymph nodes.It is rare for right-sided colon cancers to metastasize to the lateral pelvic side wall lymph nodes in the absence of local invasion or other distant metastases.In this report,we present an unusual case of a young female with pT4a right-sided ascending colon cancer with isolated metastases to the pelvic iliac lymph nodes.The patient underwent minimally invasive laparoscopic right hemicolectomy and pelvic lymph node dissection with curative intent.She recovered well with no intraoperative complications and was referred for urgent adjuvant chemotherapy and radiotherapy.

关键词： Colorectal adenocarcinoma External iliac lymph node disease positron-emission tomography Tumour staging

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^(18)F-FDG uptake as a biologic factor predicting outcome in patients with resected non-small-cell lung cancer

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Chinese Medical Journal 2007年第2期120卷 125-131页

作者： ZHANG Zhen-jiang CHEN Jing-han MENG Long DU Jia-jun ZHANG Lin LIU Ying DAI Hong-hai Department of Thoracic Surgery Shandong Provincial Hospital Shandong University Jinan 250021 China Department of Pathology Shandong Provincial Hospital Jinan 250021 China Department of Radiology Shandong Tumor Hospital Jinan 250117 China

Background The outcome of surgical treatment of non-small-cell lung cancer （NSCLC） remains poor. In many patients the biological behavior of NSCLC does not follow a definite pattern, and can not be accurately predicted before treatment. ^18F-fluoro-2-deoxy-glucose （^18F-FDG） uptake on positron-emission tomography （PET） is associated with the aggressiveness of NSCLC. The present study focused on the role of ^18F-FDG uptake in predicting the outcome of surgically treated patients with NSCLC. Methods A retrospective analysis was made of 82 patients who underwent complete resection and preoperative FDG PET. The maximum standardized uptake value （SUVmax）, in addition to five clinicopathological factors and three biomolecular factors, which could possibly influence survival, was compared for possible association with patients＇ recurrence and survival, by the Log-rank test in univariate analysis and the Cox proportional hazards model in multivariate analysis. The association between SUVmax and other factors was also analyzed. Results Patients with SUVmax more than 11 had a disease-free survival and overall survival shorter than patients with SUVmax less than 11 in univariate analyses （P〈0.001, P=0.002）. In the multivariate analysis, SUVmax （dichotomized by 11） was the only significant predictor for tumor recurrence. TNM stage and SUVmax （dichotomized by 11） were independent predictors for the overall survival. Associations of SUVmax with p53 overexpression, proliferating cell nuclear antigen （PCNA） labeling index and microvascular density of the tumor were significant in the entire group. Conclusions ^18F-FDG uptake on PET may be used to noninvasively assess biological aggressiveness of NSCLC in vivo, identifying the surgically-treated patients with poor prognosis who could benefit from additional therapy.

关键词： deoxyglucose positron-emission tomography carcinoma non-small-cell lung surgery prognosis

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Progress of radiation oncology： known and unknown

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Chinese Medical Journal 2014年第11期127卷 2173-2179页

作者： Liu Jing Yu Jinming Department of Radiation Oncology Shandong Cancer Hospital and Institute Shandong University Jinan Shandong 250117 China

Objective To elaborate known and unknown aspects of radiation oncology.Data sources Data cited in this review were obtained mainly from PubMed and Medline in English from 1999 to 2013,with keywords ＂individualized medicine＂,＂personalized medicine＂,＂radiation dose＂,＂radiation target＂,＂molecular targeted therapy＂,＂molecular imaging＂ and ＂functional imaging＂.Study selection Articles regarding radiation target delineation,radiation doses,new technology and equipment,combination of radiotherapy and molecular targeted therapy as well as other aspects were identified,retrieved and reviewed.Results A larger radiation field and a higher radiation dose are not always better.New equipment and technology are also not always better than conventional equipment and technologies.Effectiveness of radiotherapy combined with molecular targeted therapy needs more data to verify.Conclusion Personalized radiotherapy is the direction for the future.

关键词： individualized medicine radiotherapy positron-emission tomography targeted molecular therapy

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Sezary syndrome： a rare form of cutaneous T-cell lymphoma

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Chinese Medical Journal 2010年第14期123卷 1945-1947页

作者： ZENG Yue-ping WANG Hong-wei WANG Zhen SUN Qiu-ning JIN Hong-zhong Department of Dermatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Sezary syndrome （SS） is an erythrodermic, aggressive, cutaneous T-cell lymphoma （CTCL） characterized by a malignant T-cell clone that localizes in the blood and skin, and its diagnosis is based on clinical, histol... 详细信息

关键词： Sezary syndrome cutaneous T-cell lymphoma immunohistochemistry positron-emission tomography

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PET/CT imaging of delayed radiation encephalopathy following radiotherapy for nasopharyngeal carcinoma

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Chinese Medical Journal 2007年第6期120卷 474-478页

作者： WANG Xin-lu YIN Ji-lin LI Hua LI Xiang-dong QUAN Jiang-tao Department of Nuclear Medicine Guangzhou General Hospital of Guangzhou Millitary Command Guangzhou 510010 China Transplantation Center Third Affiliated Hospital Sun Yat-sen University Guangzhou 510630 China

Background With the significant improvement in the survival of patients with nasopharyngeal carcinoma （NPC） undergoing radiotherapy and the growing availability of the sophisticated imaging modalities, the number of radiation encephalopathy （RE） cases relating to NPC radiotherapy is increasing. In this study, we investigated the metabolic and density changes of the compromised brain tissues during delayed RE using a positron-emission tomography-computed tomography （PET/CT） to provide clinical evidences for the diagnosis of delayed RE following radiotherapy for NPC. Methods The PET/CT manifestations and the clinical data of 53 pathologically confirmed NPC patients with delayed RE following radical radiotherapy and 15 healthy volunteers were investigated. The standardized uptake values （SUV） of the bilateral temporal lobes, the occipital lobe and the brain stem were measured respectively; and then the metabolic reduction rate of 88 temporal lobes and 13 brain stems were calculated for a statistical comparison between the two groups. Results The earliest case of delayed RE in the investigated patients occurred 1.5 years after radiotherapy. Delayed RE frequently involved the inferior temporal lobe. For patients with delayed RE confirmed by clinical symptoms and imaging findings, PET maintained a 100% coincidence rate with CT; however, in the 25 temporal lobes of the 35 delayed RE patients, PET revealed obvious hypometabolic changes whereas CT displayed normal density. The incidence of brain stem metabolic reductions was 24.5% （13/53） in the investigated patients, including 4 patients with hypometabolic changes shown by PET and negative finding shown by CT. The incidence of granuloma adjacent to the hypometabolic region in the temporal lobe was 12.5% （11/88）. Conclusion Delayed RE patients exhibit significant hypometabolic changes in the inferior temporal lobe, captured by PET much earlier than by CT. PET/CT offers a valuable means for the diagnosis of delayed RE in subacute stages and granuloma formation.

关键词： nasopharyngeal carcinoma radiotherapy radiation encephalopathy positron-emission tomography tomography, computed

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^(68)Ga-PSMA PET/CT versus CT and bone scan for investigation of PSA failure post radical prostatectomy

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Asian Journal of Urology 2021年第2期8卷 170-175页

作者： Yuigi Yuminaga Chris Rothe Jonathan Kam Kieran Beattie Mohan Arianayagam Chuong Bui Bertram Canagasingham Richard Ferguson Mohamed Khadra Raymond Ko Ken Le Diep Nguyen Celi Varol Matthew Winter Nepean Urology Research Group Nepean HospitalPenrith New South WalesAustralia Nepean Radiology Research Group Nepean HospitalPenrith New South WalesAustralia

Objective:To evaluate the use of Gallium-68 prostate-specific membrane antigen positron emission tomography/computed tomography(^(68)Ga-PSMA PET/CT),compared with conventional CT abdomen/pelvis(CTAP)and whole body single photon emission CT bone scan(BS),for detection of local or distant metastasis following biochemical failure/recurrence in post-prostatectomy patients.Methods:We conducted a review of our prospectively maintained,institutional database to identify 384 patients with post-prostatectomy biochemical failure/recurrence who underwent PSMA PET/CT,CTAP and BS from February 2015 to August 2017 in Nepean Hospital,tertiary referral centre.The results of the three imaging modalities were analysed for their ability to detect local recurrence and distant metastases.PSMA PET/CT and CTAP imaging were separately performed on the same day and the BS was performed within several days(mostly in 24 h).Difference in detection rates was determined between the modalities and the Chi square test was used to determine significance.Results:A total of 384 patients were identified with a median prostate-specific antigen(PSA)of 0.465 ng/mL(interquartile range =0.19-2.00 ng/mL).Overall,PSMA PET/CT was positive for 245(63.8%)patients whereas CTAP and BS were positive in 174 patients(45.3%).A total of 98 patients(25.5%)had local or distant metastasis detected on PSMA only,while 20 patients(5.2%)had recurrences detected on CTAP but not on PSMA PET/CT.Conclusion:The use of PSMA PET/CT has a higher detection rate of predicted local or distant metastasis compared to CTAP and BS in the staging of patients with biochemical recurrences after radical prostatectomy.

关键词： Prostatic neoplasms positron-emission tomography Prostate-specific antigen Neoplasm staging Bone scan

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肌骨影像学发展方向

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中国骨与关节杂志 2014年第11期3卷 806-808页

作者：程晓光顾翔张毅军北京积水潭医院放射科 100035 解放军总医院第一附属医院放射科北京100048

1895年,德国物理学家伦琴(Roentgen)发现X线,当时照的第一张人体X线片就是他夫人的手。由于人体骨骼含钙多,密度高,与周围组织对比明显,因此非常适合X线成像。从常规X线摄片,到CT、MRI,再到PET-CT、PET-MRI以及分子影像学,100多年来,医... 详细信息

1895年,德国物理学家伦琴(Roentgen)发现X线,当时照的第一张人体X线片就是他夫人的手。由于人体骨骼含钙多,密度高,与周围组织对比明显,因此非常适合X线成像。从常规X线摄片,到CT、MRI,再到PET-CT、PET-MRI以及分子影像学,100多年来,医学影像学已成为骨科必不可少的检查方法,在各种骨科疾病的诊断、治疗和随访中发挥着不可替代的作用。医学影像学科包括放射学和核医学。

关键词： Radiography tomography,X-ray computed Magnetic resonance imaging positron-emission tomography Editorial

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