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Functionalize d 3D-printe d porous titanium scaffold induces in situ vascularized bone regeneration by orchestrating bone microenvironment

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Journal of Materials Science & Technology 2023年第22期153卷 92-105页

作者： Bo Yuan Pin Liu Rui Zhao Xiao Yang Zhanwen Xiao Kai Zhang Xiangdong Zhu Xingdong Zhang National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China College of Biomedical Engineering Sichuan UniversityChengdu 610064China

titanium(Ti)and its alloys have been extensively explored for treating load-bearing bone ***-ever,high-stress shielding,weak osteogenic activity,and insufficient vascularization remain key chal-lenges for the long-term clinical outcomes of Ti-based ***,inspired by structural and func-tional cues of bone regeneration,a silicon-doped nano-hydroxyapatite(nSiHA)/titanium dioxide(TiO_(2))composite coating with a hierarchical micro/nano-network structure is constructed on the surface of a 3D-printed porous Ti scaffold via a combined strategy of acid-alkali(AA)treatment and electrochemi-cal deposition technique,which not only endows the scaffold with excellent osteoinduction ability but can also effectively immobilize and release vascular endothelial growth factor(VEGF).The results of the in vitro cell experiments show that the functionalized Ti scaffold significantly promotes osteogenesis in bone marrow mesenchymal stem cells(BMSCs)and angiogenesis in human umbilical vein endothelial cells(HUVECs)by activating the extracellular signal-regulated protein kinase(ERK)and HIF-1αsignaling *** being implanted into a rat femoral condyle defect model,the functionalized Ti scaffold can induce in situ vascularized bone regeneration by orchestrating the two coupled processes of angio-genesis and *** findings indicate that the functionalized Ti scaffold has great potential in bone tissue regeneration and is a promising candidate for load-bearing bone defect repair.

关键词： porous titanium 3D-printing Hierarchical micro/nano-structure Bone microenvironment Vascularization Bone regeneration

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Progress in processing of porous titanium:a review

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Rare Metals 2024年第5期43卷 1932-1955页

作者： Xiao-Li Yang Xian-Feng Du Zhi-Lin Xu Zhong-Shuai Liang Li-Long Xiong Engineering Research Center of Energy Storage Materials and Devices Ministry of EducationSchool of ChemistryXi'an Jiaotong UniversityXi'an 710049China

As a novel structural and functional material,porous titanium and its alloys have been widely used in the aerospace,marine engineering and biomedical fields due to their high corrosion resistance,low density,good biocompatibility and excellent mechanical ***,in this paper,a comprehensive review of powder metallurgy(PM)(including additive manufacturing(AM)processes)for fabricating porous titanium is firstly covered in terms of their working principles,capabilities,shortcomings and ***,the influencing factors of various methods on final pore structure of porous Ti are ***,a summary of the chemical methods(CM)to obtain the porous Ti is also provided,such as dealloying method and reduction ***,the tendency and direction of preparation technology as well as application of porous titanium were prospected.

关键词： porous titanium Powder metallurgy Chemical method Pore structure Processing process

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3D printed porous titanium filled with mineralized UV-responsive chitosan hydrogel promotes cell proliferation and osteogenesis in vitro

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Journal of Materials Science & Technology 2023年第11期142卷 34-44页

作者： Jiazhao Yang Fan Liu Changshun Zhou Hejie Li Gaolin Yang Shiyuan Fang In-Seop Lee Yi Liu Hao Bai Cen Chen The First Affiliated Hospital of USTC Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Orthodontics School of StomatologyChina Medical UniversityShenyang 110002China College of Life Sciences and Medicine Zhejiang Sci-Tech UniversityHangzhou 310018China Institute of Laser Advanced Manufacturing Zhejiang University of TechnologyHangzhou 310023China Institute of Human Materials Suwon 16514Republic of Korea State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine Hangzhou 310018China

The modification of 3D printed porous titanium(Ti),especially for the internal pore structure,is critical and has received more attention to promoting its osteogenesis for clinical ***-violet(UV)responsive chitosan(CSMA),as an injectable filling material,was firstly incorporated into porous Ti,and then CSMA was in-situ mineralized by carbon oxide(CO_(2))diffusion(CSMA/CaCO_(3)).Their physical-chemical and biological properties were investigated in ***_(3) crystals within CSMA hydrogels were successfully deposited into pores of porous Ti,which exhibited favorable *** implants filled with CSMA/CaCO_(3) promoted adhesion and proliferation of bone mesenchymal stem cells(BMSCs).Moreover,Ti implant filled CSMA/CaCO_(3) hydrogels could increase alkaline phosphatase(ALP)activities,up-regulate osteopontin(OPN)and osteocalcin(OCN)expression levels,and enhance extracellular mineralization.3D printed porous Ti filled with mineralized UV-responsive chitosan hydrogel could promote proliferation and osteogenesis of BMSCs,and have great potential for the modification of porous Ti implants in bone tissue engineering.

关键词： porous titanium Chitosan Ultraviolet(UV)-responsive Mineralization Osteogenesis

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Preparation and characterization of porous titanium using space-holder technique

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Rare Metals 2009年第4期28卷 338-342页

作者： NIU Wenjuan BAI Chenguang QIU Guibao WANG Qiang WEN Liangying CHEN Dengfu DONG Lingyan College of Materials Science and Engineering Chongqing University Chongqing 400044 China

titanium-based porous materials can be used in structural applications and medical implants because of their excellent mechanical properties at elevated temperatures, good corrosion resistance and wonderful biocompatibility. However, most of the methods used to produce the porous metal can only give limited porosity and uncontrollable pore morphologies. In the present study, a newly developed method of powder metallurgy using the space-holder technique was used to fabricate porous titanium with controllable porosity. The morphological features and mechanical properties of the products were fully investigated. The results show that the porosity is in the range of 55%-75%, and the mean pore size, with an average sphericity of -0.72, is 600 μm. The plateau stresses vary between 10 MPa and 35 MPa. As predicted by the Gibson-Ashby model, the plateau stress decreases with increasing porosity.

关键词： powder metallurgy porous titanium space-holder pore morphology mechanical properties

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The optimized preparation of HA/L-TiO2/D-TiO2 composite coating on porous titanium and its effect on the behavior osteoblasts

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Regenerative Biomaterials 2020年第5期7卷 505-514页

作者： Xi Fu Xingyu Zhou Pin Liu Hewei Chen Zhanwen Xiao Bo Yuan Xiao Yang Xiangdong Zhu Kai Zhang Xingdong Zhang National Engineering Research Center for Biomaterials Sichuan UniversityNo.29Wangjiang RoadChengdu 610064China

Various surface bioactivation technology has been confirmed to improve the osteogenic ability of porous titanium(pTi)implants *** this study,a three-layered composite coating,*** layer of hydroxyapatite(HA),middle layer of loose titanium dioxide(L-TiO2)and inner layer of dense TiO2(D-TiO2),was fabricated on pTi by a combined processing procedure of pickling,alkali heat(AH),anodic oxidation(AO),electrochemical deposition(ED)and hydrothermal treatment(HT).After soaking in simulated body fluid for 48 h,the surface of the AHAOEDHT-treated pTi was completely covered by a homogeneous apatite *** MC3T3-E1 pro-osteoblasts as cell model,the cell culture revealed that both the pTi without surface treatment and the AHAOEDHT sample could support the attachment,growth and proliferation of the *** to the pTi sample,the AHAOEDHT one induced higher expressions of osteogenesis-related genes in the cells,including alkaline phosphatase,Type I collagen,osteopontin,osteoclast inhibitor,osteocalcin and zinc finger structure transcription *** thus,besides the good corrosion resistance,the HA/L-TiO2/D-TiO2-coated pTi had good osteogenic activity,showing good potential in practical application for bone defect repair.

关键词： porous titanium hydroxyapatite titanium dioxide composite coating osteoblasts

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Mechanical properties and pore structure deformation behaviour of biomedical porous titanium

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Transactions of Nonferrous Metals Society of China 2015年第5期25卷 1543-1550页

作者：王晓花李金山胡锐寇宏超西北工业大学凝固技术国家重点实验室西安710072

porous titanium has been shown to exhibit desirable properties as biomedical materials. In view of the load-bearing situation, the mechanical properties and pore structure deformation behaviour of porous titanium were studied. porous titanium with porosities varying from 36%-66% and average pore size of 230 μm was fabricated by powder sintering. Microstructural features were characterized using scanning electron microscopy. Uniaxial compression tests were used to probe the mechanical response in terms of elastic modulus and compressive strength. The mechanical properties of porous titanium were found to be close to the those of human bone, with stiffness values ranging from 1.86 to 14.7 GPa and compressive strength values of 85.16-461.94 MPa. The relationships between mechanical properties and relative densities were established, and the increase in relative density showed significant effects on mechanical properties and deformations of porous titanium. In a lower relative density, the microscopic deformation mechanism of porous titanium was yielding, bending and buckling of cell walls, while the deformation of yielding and bending of cell walls was observed in the porous titanium with higher relative density.

关键词： biomaterials porous titanium mechanical properties pore structure deformation behaviour

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Large-scale functionalization of biomedical porous titanium scaffolds surface with TiO_2 nanostructures

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Science China Materials 2018年第4期61卷 557-564页

作者： Lei Qian Peng Yu Jinquan Zeng Zhifeng Shi Qiyou Wang Guoxin Tan Chengyun Ning School of Materials Science and Engineering South China University of TechnologyGuangzhou 510641China Biomedical Engineering Key Laboratory of Guangdong Province Guangzhou 510641China Guangzhou Tieyi Middle School Guangzhou 510660China Department of Spine Surgery the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China

Construction of functional porous titanium scaffold is drawing ever growing attention, due to its effectiveness in solving the mechanical mismatch between titanium implant and bone tissue. However, the poor water permeability as well as the problem in achieving uniform surface modification inside scaffold hinders the further biomedical application of porous titanium scaffold. In this study, largescale functional Ti O2 nanostructures（nanonetwork, nanoplate and nanowire） were constructed on three-dimensional porous titanium scaffolds surface via an effective hydrothermal treatment method. These nanostructures increase the hydrophilicity of the titanium scaffold surface, facilitating the cell culture medium to penetrate into the inner pore of the scaffold. Zeta potential analyses indicate that the surface electrical properties depend on the nanostructure, with nanowire exhibiting the lowest potential at p H 7.4. The influence of the nano-functionalized scaffold on protein adsorption and cell adhesion was examined. The results indicate that the nano-functionalized surface could modulate protein adsorption and bone marrow derived mesenchymal stem cells（BMSCs） adhesion, with the nanowire functionalized porous scaffold homogeneously promoting protein adsorption and BMSCs adhesion. Our research will facilitate future research on the development of novel functional porous scaffold.

关键词： porous titanium hydrothermal nanostructure scaffold cell adhesion

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Effect of porous titanium coated with IGF-1 and TGF-β_1 loaded gelatin microsphere on function of MG63 cells

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Transactions of Nonferrous Metals Society of China 2015年第9期25卷 2974-2985页

作者：陈良建陈畅乔雪岩余琨谢丽子曹君刘蓓蕾颜阳中南大学湘雅三医院长沙410013 中南大学粉末冶金国家重点实验室长沙410083 中南大学材料科学与工程学院长沙410083

porous titanium with porosity of 60% was prepared by metal injection molding（MIM）,and coated with gelatin sustained-release microspheres which were made by improved emulsified cold condensation *** effects of porous titanium coated with insulin-like growth factor-1（IGF-1） and transforming growth factor-β1（TGF-β1） gelatin microspheres on the function of MG63 cells were evaluated in *** results show that porous titanium coated with gelatin sustained-release microspheres has no *** IGF-1 and TGF-β1 loading concentrations are positively correlative with the proliferation and differentiation of MG63 after co-culturing with the concentrations of IGF-1 and TGF-β1 gelatin microspheres in the range of 0.1-10 ng/mg and 0.25-2.5 ng/mg,*** MG63 cells exhibit the best proliferation and differentiation with the IGF-1 and TGF-β1 loading concentrations of 10 ng/mg and 2.5 ng/mg,*** joint application of IGF-1 and TGF-β1 group,which promote adhesion,proliferation and differentiation of MG63 cells,is superior to a single application group.

关键词： porous titanium gelatin microsphere insulin-like growth factor-1 transforming growth factor-β1 MG63 cell

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Implanting hydroxyapatite-coated porous titanium with bone morphogenetic protein-2 and hyaluronic acid into distal femoral metaphysis of rabbits

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Chinese Journal of Traumatology 2008年第3期11卷 179-185页

作者：彭磊边卫国梁芳慧徐华梓 Department of Orthopedic Surgery Second Affiliated Hospital & Yuying Children's Hospital Wenzhou Medical College Wenzhou 325000 China Northwest Institute for Non-ferrous Metal Research Xi'an 710016 China

Objective： To assess the osseointegration capability of hydroxyapatite-coated porous titanium with bone morphogenetic protein-2 （BMP-2） and hyaluronic acid to repair defects in the distal femur metaphysis in rabbits. Methods： porous titanium implants were made by sintering titanium powder at high temperature, which were coated with hydroxyapatite by alkali and heat treatment and with BMP-2 combined with bone regeneration materials. And hyaluronic acid was further used as delivery system to prolong the effect of BMP-2. The implants were inserted into the metaphysis of the distal femur of rabbits. The animals were killed at 6, 12 and 24 weeks to accomplish histological and biomechanical analyses. Results： According to the result of histological analysis, the osseointegration in BMP-2 group was better than that of the HA-coated porous titanium group. In push-out test, all the samples had bigger shear stress as time passed by. There was statistical difference between the two groups in 6 and 12 weeks but not in 24 weeks. Conclusion： Hydroxyapatite-coated porous titanium with BMP-2 and hyaluronic acid has a good effect in repairing defects of distal fumur in rabbits, which is a fine biotechnology for future clinical application.

关键词： porous titanium Bone morphogenetic protein-2 Hydroxyapatite Osteointegration Hyaluronic acid

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Mechanical Properties And Bioactive Surface Modification Via Alkali-Heat Treatment Of porous titanium For Biomedical Applications

Mechanical Properties And Bioactive Surface Modification Via...

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2012 International Conference on Biomaterial and Bioengineering(ICBB 2012)

作者： Wang Xiaohua Li Jinshan Hu Rui Kou Hongchao Zhou Lian State Key Laboratory of Solidification Processing Northwestern Polytechnical University

porous titanium with relative density from 0.4 to 0.64 was prepared by powder metallurgy. The porous structures were examined by scanning electron microscopy and phase constituents were analysed by X-ray diffraction. Mechanical properties of the porous titanium were investigated using a compressive test. To enhance the bioactivity of the alloy surface, alkali-heat treatment was used to modify the surface. Results indicate that the elastic modulus and plateau stress of the porous titanium samples both as-sintered and alkali and heat treatment decrease with decreasing relative density. And the relationship between relative yield stress and elastic modulus with relative density of porous titanium after alkali and heat treatment are agreement with that of as-sintered porous titanium. After alkali-heat treatment, a bioactive NaTiO layer formed on the surface of the pre-treated porous titanium. A reduction in the number and severity of this bioactive deposition was observed with the decrease in relative density of porous titanium because of the increasing surface area. In a word, The mechanical properties of the porous titanium can be tailored to match those of human bone, therefore, these bioactive porous titanium have the potential to be a bioactive implant material.

关键词： porous titanium Powder metallurgy Mechanical properties Alkali-heat treatment Bioactivity

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