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Article Preclinical evaluation of acute systemic toxicity of magnesium incorporated poly(lactic-co-glycolic acid)porous scaffolds by three-dimensional printing Jing

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Biomaterials Translational 2021年第3期2卷 272-284,I0001页

作者： Jing Long Bin Teng Wei Zhang Long Li Ming Zhang Yingqi Chen Zhenyu Yao Xiangbo Meng Xinluan Wang Ling Qin Yuxiao Lai Centre for Translational Medicine and Research and Development Institute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina Centre for Energy Metabolism and Reproduction Institute of Biomedicine and BiotechnologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina Guangdong Engineering Laboratory of Biomaterials Additive Manufacturing GuangdongGuangdong ProvinceChina Department of Orthopaedics and Traumatology The Chinese University of Hong KongHong Kong Special Administrative RegionChina Key Laboratory of Health Informatics Chinese Academy of SciencesShenzhenGuangdong ProvinceChina Centre for Translational Medicine and Research and Development Institute of Biomedical and Health EngineeringShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

Biodegradable polymer scaffolds combined with bioactive components which accelerate osteogenesis and angiogenesis have promise for use in clinical bone defect *** preclinical acute toxicity evaluation is an essential assay of implantable biomaterials to assess the biosafety for accelerating clinical *** have successfully developed magnesium(Mg)particles and beta-tricalcium phosphate(β-TCP)for incorporation into poly(lactic-co-glycolic acid)(PLGA)porous composite scaffolds(PTM)using low-temperature rapid prototyping three-dimensional-printing *** PTM scaffolds have been fully evaluated and found to exhibit excellent osteogenic capacity for bone defect *** preclinical evaluation of acute systemic toxicities is essential and important for development of porous scaffolds to facilitate their clinical *** this study,acute systemic toxicity of the PTM scaffolds was evaluated in mice by intraperitoneal injection of the extract solutions of the *** composite scaffolds with different Mg andβ-TCP content(denoted as PT5M,PT10M,and PT15M)were extracted with different tissue culture media,including normal saline,phosphate-buffered saline,and serum-free minimum essential medium,to create the extract *** evaluation was carried out following the National *** acute toxicity was fully evaluated through the collection of extensive data,including serum/organs ion concentration,fluorescence staining,and in vivo median lethal dose *** in major organs(heart,liver,and lung),and Mg ion concentrations in serum of mice,after intraperitoneal injection of the extract solutions,were measured and showed that the extract solutions of PT15M caused significant elevation of serum Mg ion concentrations,which exceeded the safety threshold and led to the death of the *** contrast,the extract solutions of PT5M and PT10M scaffolds did not cause the death of the injected *** median lethal dose of Mg ions in vivo

关键词： acute systemic toxicity clinical translation magnesium median lethal dose porous composite scaffolds

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