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Bi-weekly docetaxel and 5-fluorouracil:an effective and feasible treatment for advanced gastric cancer with poor performance status

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Gastroenterology Report 2014年第4期2卷 295-299页

作者： Yuting Tan Wenyun Li Yonghe Chen Yanhong Dengand Jian Xiao Department of Medical Oncology The Sixth Affiliated Hospital of Sun Yat-sen UniversityChina Centre for Quantitative Medicine Duke-NUS Graduate Medical SchoolNational University of SingaporeSingapore Department of Surgery The Sixth Affiliated Hospital of Sun Yat-sen UniversityChina

Background:The survival benefits from cytotoxic chemotherapy have been demonstrated in advanced gastric cancer(AGC).A large proportion of AGC patients initially present poor performance status(PS);however,most of the clinical evidence comes from trials on patients with good PS.A better-designed regimen is greatly needed for AGC patients with poor ***:To evaluate the efficacy and safety of a modified combination regimen with docetaxel plus 5-fluorouracil(5-FU)every two weeks as first-line treatment in AGC patients with poor ***:From September 2011 to December 2013,12 patients diagnosed with AGC with Eastern Cooperative Oncology Group(ECOG)PS scores of 3 or 4 were included in this *** the patients received docetaxel 60 mg/m^(2) on Day 1,5-FU 400mg/m^(2) intravenous(i.v.)bolus on Day 1,and a 46-hour continuous *** of 5-FU 2400mg/m^(2) every two weeks,until disease progressed or patients experienced unacceptable toxicity or declined *** clinical,pathologic and survival data were all ***:Eleven out of 12 patients were assessable for responses,whereas nine cases(75%)achieved partial response,one(8.3%)achieved stabilized disease,and one(8.3%)had progressive *** median progression-free survival was 6.5 months(95%CI:4.8–8.2).The median overall survival was 12.0 months(95%CI:9.0–15.0).The most common Grade 3/4 toxicities were anemia in seven patients(58.3%).No patient experienced febrile ***:The novel modification of bi-weekly docetaxel and 5-FU is a promising treatment option for AGC with poor PS,showing great efficacy and acceptable toxicity.

关键词： advanced gastric cancer docetaxel 5-fluorouracil poor performance status

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