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pomolic acid and its glucopyranose ester promote apoptosis through autophagy in HT-29 colon cancer cells

World Journal of Gastrointestinal Oncology 2023年第10期15卷 1756-1770页

作者： Li-Yan Liu Teng-Hua Yu Tie-Song Liao Peng Xu Ying Wang Min Shi Bin Li Workstation of Academician Jiangxi University of Chinese MedicineNanchang 330004Jiangxi ProvinceChina Department of Pharmacy Jiangxi Cancer Hospital and Jiangxi Cancer CenterNanchang 330029Jiangxi ProvinceChina Department of Breast Surgery Jiangxi Cancer Hospital and Jiangxi Cancer CenterNanchang 330029Jiangxi ProvinceChina Laboratory Animal Science and Technology Center Jiangxi University of Chinese MedicineNanchang 330004Jiangxi ProvinceChina Department of Pharmacy Shangrao Health SchoolShangrao 334000Jiangxi ProvinceChina

BACKGROUND Colon cancer remains a leading cause of death *** acid(PA)can be separated from the ethyl acetate fraction of achyrocline *** To determine the effects of PA and its glucopyranose ester,pomolic acid-28-O-β-D-glucopyranosyl ester(PAO),on colon cancer HT-29 *** 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay was used to measure cell *** was detected via hoechst 33342 *** single staining was identified by flow cytometry to determine the cycle and scratch assay was used to observe the migration of HT-29 *** levels of mRNA and proteins were evaluated by q polymerase chain reaction and western blotting,*** PA and PAO considerably inhibited the growth of the HT-29 cell line in a time and dose-dependent *** the administration of PA and PAO for 24 and 48 h,cell apoptosis was significantly promoted and HT-29 cells were arrested in the G0/G1 *** Bax/Bcl2 ratio was also increased,which activated cysteinyl aspartate specific proteinase 3,leading to apoptosis;it also increased the expression of light chain 3 II/I and Beclin1,which activated autophagy and caused cell *** in turn increased the expression of p62 to promote cell apoptosis,inhibiting the levels of signal transducer and activator of transcription 3(STAT3)and p-STAT3,suppressing the level of Bcl2,and promoting *** Both PA and PAO provide novel therapeutic strategies for treating colorectal cancer.

关键词： Colon cancer Achyrocline satureioides pomolic acid pomolic acid-28-O-β-D-glucopyranose

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Thin Layer Chromatography and Chemometric Studies of Selected Potentilla Species

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American Journal of Analytical Chemistry 2014年第16期5卷 1109-1120页

作者： Ryszard Swieboda Agnieszka Józwiak Grzegorz Józwiak Monika Waksmundzka-Hajnos Department of Inorganic Chemistry Medical UniversityLublinPoland

Herbal medicinal products have a long-standing therapeutic record. To ensure the quality of herbal products specific identification tests which allow experts to discriminate related species and/or potential adulterants/substitutes are required. The purpose of the research was to recommend an original and simple method for the separation of closely related five triterpenic acids (ursolic, oleanolic, tormentic, euscaphic, pomolic acid) and its application to chemotaxonomy studies. 17 standard samples of Potentilla species and 3 test samples were chromatographed (with or without prechromatographic derivatization) on silica gel plates using the mobile phase: chloroform-diethyl ether-methanol-formic acid (30:10:1:0.2 v/v/v/v);they were subsequently derivatized, and visualized in UV 366 nm light. After images received pre-treatment (montaging stack, removal of noise, background subtract, horizontal equalization, two types of warping) exploratory analysis of the investigated Potentilla species fingerprints was processed. The method without prechromatographic derivatization was used to create differential fingerprints. Good results were obtained by the application of r-project iterative algorithm for subtract background and our simple algorithm for warping to image processing of TLC chromatograms for the first time.

关键词： pomolic acid Ursolic acid Euscaphic acid Tormentic acid Oleanolic acid Triterpene acids TLC Fingerprint Potentilla

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Chemical Constituents in Charred Sanguisorbae Radix

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Chinese Herbal Medicines 2013年第1期5卷 1-4页

作者： SUN Li-li ZHONG Ying XIA Hong-min ZHOU Qian LV Jia Shandong Academy of Chinese Medicine Key Laboratory for Modern Medicine and Technology of Shandong Province Instituent of Materia MedicaShandong Academy of Medical Sciences

Objective To study the chemical constituents in the effective fractions of charred Sanguisorbae Radix. Methods The compounds were isolated and purified by column chromatography and their structures were identified on the basis of physicochemical properties and spectral analysis. Results Five compounds were isolated and identified as 3β-hydroxy-28-norurs-17,19,21-trien (1), 3β-hydroxy-28-norurs-12,17-dien (2), 3β,19α-dihydroxyurs-13(18)- en-28-oic acid (3), 3β-[(α-L-arabin-opyranosyl) oxy]-28-norurs-12,17-dien (4), and pomolic acid (5). Conclusion Compounds 1, 3, and 4 are novel compounds belong to triterpenoids and triterpenoid saponins, named as sanguisorbigenins Z, Y1 , and Y2 , respectively.

关键词： charred Sanguisorbae Radix pomolic acid sanguisorbigenin Y1 sanguisorbigenin Y2 sanguisorbigenin Z

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Triterpenes from the root of Viburnm Schensianum Maxim

Triterpenes from the root of Viburnm Schensianum Maxim

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中国化学会第十二届全国天然有机化学学术会议

作者： Dexiong Zhou Lili Hao Chenguo Li Gaorong Zhang Wei Liu Yanjun Zhang Jun Li State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources College of Chemistry and Pharmaceutical SciencesGuangxi Normal University

Viburnm schensiamum maxim,family of Capnifoliacea,is mainly distributing in Guangxi,Yunnan,Shanxi,Sichuan and other western provinces of *** genus Viburnum plants’ roots,barks,leaves and fruits have been widely used as folk medicines to cure heat-clearing and detoxifying,astringent pulse hemostatic,chronic bronchitis,cancer,influenza,rheumatism bone pain,and waist *** to now,rare report about the research on the constituents and pharmacology of *** was *** order to study constituents and search for bioactive compounds,the root of V. Schensianum constituents was isolated using silica gel CC,reversed silica gel CC,Sephadex LH-20 CC,and preparative *** known triterpenes were *** structures were determined by NMR,ESIMS *** are pomolic acid(1),uvaol(2),tormentic acid(3),soyasapogrnol B(4),ursolic acid(5).Compounds 1,2,3,and 4 were found in *** for the first time.

关键词： Viburnm Schensianum Maxim Capnifoliacea pomolic acid uvaol tormentic acid

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