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Enhanced absorption and inhibited metabolism of emodin by 2,3,5,4＇-tetrahydroxystilbene-2-O-β-D-glucopyranoside： Possible mechanisms for polygoni multiflori radix-induced liver injury

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Chinese Journal of Natural Medicines 2017年第6期15卷 451-457页

作者： YU Qiong JIANG Li-Long LUO Na FAN Ya-Xi MA Jiang LI Ping LI Hui-Jun State Key Laboratory of Natural Medicines China Pharmaceutical University Nanjing 210009 China

polygoni multiflori radix(PMR) has been commonly used as a tonic in China for centuries. However, PMR-associated hepatotoxicity is becoming a safety issue. In our previous in vivo study, an interaction between stilbenes and anthraquinones has been discovered and a hypothesis is proposed that the interaction between stilbene glucoside-enriching fraction and emodin may contribute to the side effects of PMR. To further support our previous in vivo results in rats, the present in vitro study was designed to evaluate the effects of 2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-D-glucopyranoside(TSG) on the cellular absorption and human liver microsome metabolism of emodin. The obtained results indicated that the absorption of emodin in Caco-2 cells was enhanced and the metabolism of emodin in human liver microsomes was inhibited after TSG treatment. The effects of the transport inhibitors on the cellular emodin accumulation were also examined. Western blot assay suggested that the depressed metabolism of emodin could be attributed to the down-regulation of UDP-glucuronosyltransferases(UGTs) 1A8, 1A10, and 2B7. These findings definitively demonstrated the existence of interaction between TSG and emodin, which provide a basis for a better understanding of the underlying mechanism for PMR-induced liver injury.

关键词： polygoni multiflori radix Hepatotoxicity Emodin 2,3,5,4’-Tetrahydroxystilbene-2-O-β-D-glucopyranoside Component interaction

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Spectrum-Toxicity Correlation Study Revealed the Influence of the Nine-Time Steaming and Sun Drying Method on Hepatotoxic Components of polygoni multiflori radix

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World Journal of Traditional Chinese Medicine 2021年第2期7卷 227-233页

作者： Zhuo Shi Xiao-Fei Li Ya-Lei Liu Peng-Yan Li Ming Niu Zhao-Fang Bai Guang-Qin Zhang Yang Lu Jia-Bo Wang Clinical Pharmacokinetics Laboratory School of Basic Medicine and Clinical PharmacyChina Pharmaceutical UniversityNanjing The Fifth Medical Center China Military Institute of Chinese MedicineGeneral Hospital of PLABeijingChina

Objective:polygoni multiflori radix(PM)is a traditional herbal medicine with repeated reports of liver injury events in recent *** wondered whether the classical processing method,namely,nine-time steaming and sun drying(NSSD),had toxicity-attenuating effects on PM and the relationships between toxicity and times of processing,as well as with the alteration trends of its *** and Methods:The chemical fingerprints of different PM extracts were developed using ultra-high-performance liquid *** spectrum-toxicity correlation between the chemical fingerprints and hepatocellular toxicity was analyzed with multiple correlation ***:The results suggested that the hepatotoxicity of NSSD processing products markedly decreased with the repeated steaming and sun drying,which was obviously superior to the product processed by the modern *** analysis revealed that the contents of cis-stilbene glycoside and emodin-8-O-β-D-glucoside related to liver injury susceptibility were reduced with the times of NSSD processing,which was consistent with the decreased trend of hepatocellular *** the five times of NSSD,the contents of them as well as the hepatotoxicity of PM were ***,we found that the contents of catechin and physcion declined rapidly after the one time of NSSD and then remained stable until the nine times of *** on the fact,they could be utilized to indicate whether PM products were processed by steaming and sun ***:This paper confirmed that the NSSD had a good influence on the toxicity attenuating to PM and found four compounds which could apply for the quality control of PM.

关键词： Hepatotoxicity nine-time steaming and sun drying polygoni multiflori radix spectrum-toxicity correlation toxicity attenuation by processing

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Simultaneous Determination of Four Anthraquinones in polygoni multiflori radix with Single Reference Standard by High Performance Liquid Chromatography

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World Journal of Traditional Chinese Medicine 2015年第3期1卷 21-26页

作者： Hua Yang Jun-Fang Jia Rui Wang Fang Long Ping Li Hui-Jun Li State Key Laboratory of Natural Medicines China Pharmaceutical University

Objective: To establish a rapid, accurate and reliable analytical method for the simultaneous determination of four major anthraquinones in polygoni multiflori radix(PMR) using single reference ***: The four components including emodin-8-O-β-D-(EMG), physcion-8-O-β-D-glucoside, emodin and physcion were separated on an ODS C18 column within 13 min and detected at 280 nm. Emodin was selected as the reference standard, and the response factor for each analyte with respect to emodin were calculated. Robustness were also tested including different columns, equipments, temperatures, detection wavelengths, and other chromatographic conditions which might influence stability of response ***: The method was validated in terms of linearity(r^2> 0.9995), LOQs(0.820–3.05 ng/m L), LODs(0.180–0.920 ng/m L), precision,accuracy(95.8–103.6%, RSD < 2.80%) and stability. A total of 40 batches of PMR were analyzed and the results were found to have no statistically significant differences compared with those obtained using the external standard ***: This work provided a single standard to determine multi-components method for quantitation of four anthraquinones in PMR,which could be applied in the quality control of this herbal drug.

关键词： polygoni multiflori radix Single standard to determine multi-components method Anthraquinone Emodin

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Hepatoprotection and hepatotoxicity of Heshouwu, a Chinese medicinal herb: context of the paradoxical effect

Hepatoprotection and hepatotoxicity of Heshouwu, a Chinese m...

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第二届临床中药学大会

作者： Hongliang Li Xuanbin Wang Ying Liu Dongfeng Pan Ye Wang Nian Yang Longchao Xiang Xiaojun Cai Yibin Feng Laboratory of Chinese Herbal Pharmacology Oncology Center Renmin Hospital Hubei University of Medicine Biomedical Research Institute Hubei Key Laboratory of Wudang Local Chinese Medicine Research Hubei University of Medicine School of Chinese Medicine the University of Hong Kong

Heshouwu（Polygonum multiflorum Thunb.） has been a common Chinese medicine and a folk Taoist medicine for over a thousand years. There are two drug forms, Shengshouwu（polygoni multiflori radix） and Zhiheshouwu（polygoni multiflori radix Prapaerata） in the Chinese Pharmacopoeia. In this review, we retrieved articles with such keywords as Heshouwu, liver protection and liver toxicity in the databases of PubMed and the China National Knowledge Infrastructure（CNKI）. Hepatoprotection and hepatotoxicity of Shengshouwu and Zhiheshouwu in vitro and in vivo, and their clinical settings and adverse drug reactions（ADR） were summarized, analyzed and critically reviewed. In bench research, both drug forms had effects against nonalcoholic fatty liver disease, oxidation, fibrosis, cirrhosis, and liver cancer. Clinically, Heshouwu was used for treating fatty liver disease（FLD）, hyperlipidemia, cirrhosis and hepatitis B. In contrast, both drug forms could lead to drug-induced liver injury and even death in vitro, in vivo and in clinical settings. In addition, active components of both drug forms had hepatic benefits and toxicity in interaction with emodin, physcion, and probably 2,3,5,4’-tetrahydroxy-stilbene-2-O-beta-dglucoside（TSG）. In conclusion, Heshouwu exhibited both hepatoprotection and hepatotoxicity. It is essential to evaluate the advantages and disadvantages when Heshouwu is in clinical use. The study was financially supported by the Young Scientist Innovation Team Project of Hubei Colleges（T201510）;the Hubei Province Health and Family Planning Scientific Research Project（WJ2017 Z023）;the Open Project of Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine（WDCM001）;the Key Discipline Project of Hubei University of Medicine and the Foundation for Innovative Research Team of Hubei University of Medicine（2014 CXG03）;the Key Discipline Project of Hubei Province（2014 XKJSXJ18）.

关键词： polygoni multiflori radix hepatoprotection hepatotoxicity

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