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Gene Expression of Ornithine Decarboxylase in Lung Cancers and Its Clinical Significance

Acta Biochimica et Biophysica Sinica 2006年第9期38卷 639-645页

作者： Hui TIAN~1* Qing HUANG~1 Lm LI~1 Xian-Xi LIU~2 Yan ZHANG~2 1 Department of Thoracic Surgery,Shandong University Qi Lu Hospital,Jinan 250012,China 2 Department of Medicine,Medical Molecular Biology Experimental Center,Shandong University,Jinan 250012,China DeportmentofThoracicSurgery ShandongUniversityQiLuHospitalJinon250012China DepartmentofMedicine MedicalMolecularBiologyExperimentalCenterShandongUniversityJinan250012China

Lung cancer is one of the most lethal cancers in China because of its high incidence and *** decarboxylase （ODC）,an important enzyme in polyamine biosynthesis,is increased incancer *** chemotherapeutic agents aimed at reducing ODC expression show inhibitory effects oncancer cell growth,so ODC can be useful in gene diagnosis and gene therapy of *** this study,weexamined the effect of antisense ODC on lung cancer cells.A-549 cells were infected with rAd-ODC/Ex3as,a recombinant adenovirus containing the cytomegalovirus promoter,green fluorescent protein gene and 120bp antisense *** cell cycle was evaluated by flow cytometry.A nude mouse xenograft model wasused in the tumorigenicity *** transcription-polymerase chain reaction,Western blot and immuno-histochernistry were used to study the expressions of ODC on lung *** was found that the growth ofcells infected with rAd-ODC/Ex3as was substantially inhibited and cells were arrested at *** with rAd-ODC/Ex3as can suppress tumor formation in a nude mouse xenograft *** of ODC mRNA and ODC protein levels in lung cancer tissues was significantly higher than thatin normal tissues （P<0.05）,which correlated significantly with the stage of lung cancer （P<0.05）.This studysuggested that rAd-ODC/Ex3as has antitumor activity in human lung cancer *** ODC gene might playan important role in lung cancer and the overexpression of ODC might be related to the occurrence anddevelopment of lung cancer.

关键词： polyamine biosynthesis lung neoplasm ornithine decarboxylase A-549 cell line

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Exploring polyamines:Functions in embryo/fetal development

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Animal Nutrition 2017年第1期3卷 7-10页

作者： Tarique Hussain Bi'e Tan Wenkai Ren Najma Rahu Dildar Hussain Kalhoro Yulong Yin National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production Institute of Subtropical AgricultureKey Laboratory of Agro-EcologyInstitute of Subtropical AgricultureThe Chinese Academy of Sciences University of Chinese Academy of Sciences Hunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients Hunan Collaborative Innovation Center of Animal Production Safety Department of Veterinary Microbiology Faculty of Animal Husbandry and Veterinary SciencesSindh Agriculture University

polyamines such as putrescine, spermidine, spermine and agmatine are aliphatic polycationic compounds present in all living cells, and are derived from amino acids, intestinal bacteria, exfoliated enterocytes and supported from diet. polyamines as the key compounds play essential role in cell proliferation, growth and differentiation. They also exert significant effects on embryonic development,implantation, embryonic diapause, placentation, angiogensis and fetal development. This review paper summarizes the functions of polyamines and embryo/fetus development and its regulatory mechanism which should help to provide some evidences for clinic.

关键词： polyamines polyamine biosynthesis Embryo/fetus development

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