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Enhancing the stability of astaxanthin by encapsulation in poly (1-lactic acid) microspheres using a supercritical anti-solvent process

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Particuology 2019年第3期17卷 54-62页

作者： Guijin Liu Man Hu Ziyi Zhao Qing Lin Dongwei Wei Yanbin Jiang School of Chemistry and Chemical Engineering South China University of Technology Guangzhou 510640 China

To improve the physicochemical properties of astaxanthin, it was encapsulated in poly (1-lactic acid)(PLLA) using a supercritical anti-solvent (SAS) process with dichloromethane/acetone mixture as the solvent, and supercritical CO2 as the anti-solvent. The effects of altering five SAS operating cond让ions, solvent ratio, temperature, pressure, concentration of carrier, and flow rate, on the microstructure of particles were investigated using an orthogonal experimental design. Under the optimal conditions, astaxanthin/PLLA particles were produced with an encapsulation efficiency of 91.5% and a mean particle size of 954.6 nm. SEM images showed that most astaxanthin/PLLA particles were uniform microspheres. FT-IR spectra showed that the chemical structure of astaxanthin was unchanged by the SAS process. The results of chromatic difference, X-ray diffraction, thermogravimetric, and differential scanning calorimetry analyses showed that astaxanthin had been encapsulated in the PLLA matrix in an amorphous state. Overall, astaxanthin/PLLA microspheres greatly enhanced the stability of astaxanthin during storage, and the levels of residual solvents were far lower than the ICH lim让s. This means that astaxanthin/PLLA microspheres prepared using SAS show great potential for use in many food, cosmetic, and pharmaceutical formulations.

关键词： Astaxanthin poly (1-lactic acid) Encapsulation Supercritical anti-solvent Stability

Insight into fouling behavior of poly(vinylidene fluoride)(PVDF)hollow fiber membranes caused by dextran with different pore size distributions

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Chinese Journal of Chemical Engineering 2018年第2期26卷 268-277页

作者： Kailiang Zeng Jie Zhou Zhaoliang Cui Yue Zhou Chuan Shi Xiaozu Wang Liyue Zhou Xiaobin Ding Zhaohui Wang Enrico Drioli State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 210009China National Engineering Research Center for Speical Separation Membrane Nanjing Tech UniversityNanjing 210009China Nanjing Jiuying Membrane Technologies Co. Ltd.Nanjing 211899China Research Institute on Membrane Technology ITM-CNRVia Pietro Bucci 17/CRende 87036Italy

Membrane fouling is the key problem that occurs in membrane process for water treatment. However, how membrane microstructure influences the fouling behavior is still not clear. In this study, fouling behavior caused by dextran was deeply and systematically investigated by employing four poly(vinylidene fluoride)(PVDF)membranes with different pore sizes, ranging from 24 to 94 nm. The extent of fouling by dextran was accurately characterized by pore reduction, flux decline, and the change of critical flux. The result shows that membrane with the smallest pore size of 24 nm experienced the smallest fouling rate and the lowest fouling extent. As the membrane pore size increased, the critical flux ranges were 105-114, 63-73, 38-44 and 34-43 L·m^(-2)·h^(-1),respectively. The critical flux and fouling resistances indicated that the fouling propensity increases with the increase of membrane pore size. Two pilot membrane modules with mean pore size of 25 nm and 60 nm were applied in membrane filtration of surface water treatment. The results showed that serious irreversible membrane fouling occurred on the membrane with pore size of 60 nm at the permeate flux of40.5 L·m^(-2)·h^(-1).On the other hand, membrane with pore size of 25 nm exhibited much better anti-fouling performance when permeate flux was set to 40.5,48 and 60 L·m^(-2)·h^(-1).

关键词：纤维膜 poly 葡聚糖氟化物毛孔行为缩放微观结构

Functionalization of small black phosphorus nanoparticles for targeted imaging and photothermal therapy of cancer

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Science Bulletin 2018年第14期63卷 917-924页

作者： Lijuan Deng Yifan Xu Caixia Sun Baofeng Yun Qiao Sun Chongjun Zhao Zhen Li Key Laboratory for Ultrafine Materials of Ministry of Education. Shanghai Key Laboratory of Advanced polymeric Materials School of Material Science and Engineering East China University of Science and Technology Shanghai 200237 China Center for Molecular imaging and Nuclear Medicine State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences (PAD-X) Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Soochow University Suzhou 215123 China College of Textile and Clothing Engineering Soochow University Suzhou 215123 China

Black phosphorus(BP) nanomaterials have attracted extensive attention due to their unique physical,chemical, and biological properties. In this study, small BP nanoparticles were synthesized and modified with dextran and poly(ethyleneimine) for functionalization with folic acid and cyanine 7. The functionalized BP nanoparticles exhibit excellent biocompatibility, stability, and near infrared optical properties for targeted imaging of tumors through photoacoustic imaging and near-infrared fluorescence imaging.They also display high photothermal conversion efficiency for photothermal therapy of cancer. This work demonstrates the potential of functionalized small BP nanoparticles as an emerging nanotheranostic agent for the diagnosis and treatment of cancer.

关键词：荧光成像癌症治疗指向磷近红外线 poly 变换效率

Mechanical Properties of Interlocked-ring polymers: A Molecular Dynamics Simulation Study

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Chinese Journal of polymer Science 2019年第12期37卷 1298-1304,I0008页

作者： Zheng-Tao Wu Jia-Jia Zhou College of Engineering Zhejiang Normal UniversityJinhua 321004China School of Chemistry Beihang UniversityBeijing 100191China

Interlocked-ring polymers,also known as polycatenanes,possess an interesting molecular architecture.These polymers are composed of many interlocked rings in a linear chain.The topological constrain between neighboring rings distinguishes the interlockedring polymer from its linear counterpart.Here we present extensive molecular dynamic simulations on the interlocked-ring polymers and analyze the static properties of the polymer.By applying external forces to the polymer,we also study the force-extension curves of the polymer,which provides rich information about the mechanical properties of the interlockedring polymers.

关键词： poly catenanes Molecular dynamics simulation Force-extension Entanglement

poly(Ethylene Oxide) Mediated Synthesis of Sub-100-nm Aluminum Nanocrystals for Deep Ultraviolet Plasmonic Nanomaterials

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CCS Chemistry 2020年第4期2卷 516-526页

作者： Shuang Yang Shaoyong Lu Yang Li Hua Yu Linxia He Tianmeng Sun Bai Yang Kun Liu State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun130012 The First Bethune Hospital and Institute of Immunology Jilin UniversityChangchun 130021 State Key Laboratory of Applied Optics Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130012

Aluminum nanocrystals(Al NCs)are sustainable plasmonic nanomaterials with unique localized surface plasmonic resonance(LSPR)in the ultraviolet(UV)region.Chemical synthesis of sub-100-nm Al NCs remains a considerable challenge due to the lack of effective ligands to control their growth.Here,we describe a precise size-controlled synthesis of small colloidal Al NCs(25–100 nm)with strong and tunable LSPR peak from 250 to 372 nmin the UV spectral region by the use of poly(ethylene oxide)(PEO)as a polydentate surface ligand.

关键词： aluminum nanocrystal UV plasmonics polymer ligands size-controlled synthesis poly (ethylene) oxide

Direct site-specific treatment of skin cancer using doxorubicin-loaded nanofibrous membranes

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Science Bulletin 2018年第2期63卷 92-100页

作者： Mengyu Guo Guoqiang Zhou Zhu Liu Jing Liu Jinglong Tang Yating Xiao Wenshi Xu Ying Liu Chunying Chen CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190 China Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education College of Chemistry and Environmental Science Hebei University Baoding 050011 China University of Chinese Academy Sciences Beijing 100049 China

Doxorubicin(DOX) is widely used in cancer therapy. However, its application is sometimes limited by its adverse cardiotoxicity and delivery pathways. In our study, we prepared a topical implantable delivery device for controlled drug release and site-specific treatment. The core region consisted of poly(lactic co-glycolic acid) and poly-caprolactone, whereas the shell region was composed of cross-linked gelatin.DOX was enclosed in the core region of a core-shell nanofiber obtained by electrospinning. This implantable delivery device was implanted on the top of the melanoma in a mouse model, which had shown a DOX-controlled release profile with sustained and sufficient local concentration against melanoma growth in mice with negligible side effects. Compared with the traditional intravenous administration,the implantable device allows precisely localized treatment and therefore can reduce the dose, decrease the injection frequency, and ensure antitumor efficacy associated with lower side effects to normal tissues. Using a coaxial electrospinning process, it is promising to deliver different hydrophobic or hydrophilic drugs for direct tumor site-specific therapy without large systemic doses and minimized systemic toxicity.

关键词：癌症治疗地点装载 poly 副作用植入膜影片

poly I:C母体免疫刺激诱导的子代精神分裂症神经发育动物模型

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心理科学 2015年第1期38卷 229-236页

作者：王佳许燕李国海常宪鲁周莹张维宁江苏大学医学院镇江212013 江苏省镇江市精神卫生中心镇江212000

精神分裂症是一组病因未明的重性精神障碍,其病理生理学机制极其复杂,建立能够确切模拟精神分裂症的动物模型对于其发病机制的研究及抗精神分裂症药物的研发具有十分重要的意义。本文意在介绍产前母体免疫刺激(聚肌胞苷酸聚肌苷酸-聚胞... 详细信息

精神分裂症是一组病因未明的重性精神障碍,其病理生理学机制极其复杂,建立能够确切模拟精神分裂症的动物模型对于其发病机制的研究及抗精神分裂症药物的研发具有十分重要的意义。本文意在介绍产前母体免疫刺激(聚肌胞苷酸聚肌苷酸-聚胞苷酸,poly I:C)诱导子代出现精神分裂症样的神经发育动物模型,以及该模型对精神分裂症的病因研究、生物学机制及其治疗和药物研发的重要意义。

关键词：精神分裂症动物模型产前免疫刺激 poly I:C

High-efficiency acetaldehyde removal during solid-state polycondensation of poly(ethylene terephthalate) assisted by supercritical carbon dioxide

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Chinese Journal of Chemical Engineering 2018年第6期26卷 1285-1291页

作者： Zhenhao Xi Tian Liu Wei Si Fenglei Bi Zhimei Xu Ling Zhao State Key Laboratory of Chemical Engineering East China University of Science and Technology

The concentration of acetaldehyde(AA) is the main quality index of poly(ethylene terephthalate)(PET) used in food and drink packaging.A new method for AA removal has been developed by using supercritical carbon dioxide(sc CO2) during the solid-state polycondensation of PET.The influence factors of AA removal including the temperature,pressure,reaction time and the size of pre-polymer particles are systematically studied in this work.The results indicate that it is a highly efficient way to obtain high molecular weight PET with relative low concentration of AA.Correspondingly,the polymerization degree of PET could increase from 27.9 to 85.6 while the concentration of AA reduces from 0.229 × 10^(-6) to 0.055 × 10^(-6) under the optimal operation conditions of 230 °C,8 MPa and size of 0.30–0.45 mm.Thermodynamic performance tests show the increasing extent of PET crystallinity due to the fact that the plasticization of sc CO_2 is not obvious with extended reaction time,therefore the increasing crystallinity has no significant influence on AA removal.SEM observations reveal that the effects of sc CO_(2-) induced plasticization and swelling on PET increase significantly with the decrease of prepolymer size,and the surface of PET becomes more loose and porous in favor of the AA removal.

关键词： poly 二氧化碳移动固态乙醛乙烯影响因素反应时间

Preparation of poly(lactide-co-glycolide)microspheres and evaluation of pharmacokinetics and tissue distribution of BDMC-PLGA-MS in rats

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Asian Journal of Pharmaceutical Sciences 2018年第1期13卷 82-90页

作者： Guozhuan Li Liang Yao Jing Li Xiaoyan Qin Zhen Qiu Weidong Chen Anhui University of Chinese Medicine Hefei First People's Hospital

The aim of the present study was to develop a novel long-acting poly(lactic-co-glycolic acid)(PLGA)-based microspheres formulation of Bisdemethoxycurcum(BDMC) by emulsionsolvent evaporation method. Meanwhile, the effects of the volume ratio of the dispersed phase and continuous phase, the concentration of PLGA and PVA, the theoretical drug loading and stirring speed were investigated. The mean diameter of the microspheres was 8.5 μm and the size distribution was narrow. The encapsulation efficiency(EE) and drug loading efficiency(DLE) of BDME loaded PLGA microspheres(BDMC-PLGA-MS) was 94.18% and 8.14%,respectively. In an in vitro study of drug release, it can be concluded that the BDMC-PLGAMS exhibited sustained and long-term release properties for 96 h. Stability studies suggested that the microspheres we prepared had a very good stability. Furthermore, the results of an in vivo study indicated that the BDMC-PLGA-MS had sustained release effect and was mainly distributed in the lung tissue, and less distribution in other tissues, which indicated that microspheres could be an effective parenteral carrier for the delivery of BDMC in lung cancer treatment.

关键词： Bisdemethoxycurcumin Microsphere poly (lactic-co-glycolic acid) Solvent evaporation method Pharmacokinetics