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Metagenomic next-generation sequencing for pleural effusions induced by viral pleurisy:A case report

World Journal of Clinical Cases 2023年第4期11卷 844-851页

作者： Xue-Ping Liu Chen-Xue Mao Guan-Song Wang Ming-Zhou Zhang Institute of Respiratory Disease Xinqiao HospitalThird Military Medical UniversityChongqing 400037China Department of Laboratory Diagnosis Chongqing KingMed Center for Clinical Laboratory Co.LtdChongqing 400050China

BACKGROUND Viral pleurisy is a viral infected disease with exudative pleural *** is one of the causes for pleural *** of the difficult etiology diagnosis,clinically pleural effusions tend to be misdiagnosed as tuberculous pleurisy or idiopathic pleural ***,we report a case of pleural effusion secondary to viral pleurisy which is driven by infection with epstein-barr *** infection was identified by metagenomic next-generation sequencing(mNGS).CASE SUMMARY A 40-year-old male with a history of dermatomyositis,rheumatoid arthritis,and secondary interstitial pneumonia was administered with long-term oral *** presented with fever and chest pain after exposure to cold,accompanied by generalized sore and weakness,night sweat,occasional cough,and few *** computed tomography scan showed bilateral pleural effusions and atelectasis of the partial right lower lobe was *** pleural fluids were found to be yellow and slightly turbid after pleural *** showed fibrous adhesion and *** the results in pleural fluid analysis and mNGS,the patient was diagnosed as viral *** receiving Aciclovir,the symptoms and signs of the patient were *** Viral infection should be considered in cases of idiopathic pleural effusion unexplained by routine *** is helpful for diagnosis.

关键词： pleural effusions Viral pleurisy Metagenomic next-generation sequencing Epstein-barr virus Infection Case report

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The diagnostic significance of the detection of cytokeratin 19 mRNA by quantitative RT-PCR in benign and malignant pleural effusions

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Journal of Zhejiang University Science 2004年第10期5卷 1286-1289页

作者：徐峰陈杰沈华浩王选锭单江 SecondAffiliatedHospital CollegeofMedicineZhejiangUniversityHangzhou310009China

Objective: To evaluate the diagnostic significance of detecting cytokeratin 19 (CK19) mRNA by quantitative reverse transcription polymerase chain reaction (RT-PCR) in benign and malignant pleural effusions. Methods: CK19 mRNA was examined by quantitative RT-PCR and CK19 was detected by Enzyme-linked immunoadsorbent assay (ELISA) in 32 patients with malignant pleural effusions and 35 patients with benign pleural effusions. Results: On the threshold of 200 copies/μl, the positive rate of CK19 mRNA in patients with malignant pleural effusions was 62.5%. The positive rates of CK19 mRNA and CK19 in the malignant pleural effusions were significantly higher than those in the benign group (Ppleural effusions.

关键词： Cytokeratin 19 mRNA Quantitative reverse transcription polymerase chain reaction pleural effusions

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Detection of hTERT mRNA,CEA,CA19-9 in pleural Effusion and Its Clinical Significance

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Chinese Journal of Clinical Oncology 2008年第2期5卷 132-135页

作者： Niangui Zhao Xiaoqun Ye Weilan Yang Yeqing Zou Chunsong Yan Department of Respiratory Diseases the Second Affiliated Hospital of Nanchang University Nanchang 330006 Jiangxi province China. Jiangxi provincial Key Laboratory of Molecular Medicine the Second Affiliated Hospital of Nanchang University Nanchang 30006 Jiangxi province China.

OBJECTIVE To explore the clinical significance of the human telomerase reverse transcriptase(hTERT)mRNA,CEA and CA19-9 in differential diagnosis of benign and malignant pleural effusions. METHODS Concentrations of CEA and CA19-9 in pleural effusions were assayed using automated chemiluminescence,and expression of hTERT mRNA was detected by RT-PCR. RESULTS The positive rates of hTERT mRNA,CEA and CA19-9 expression in the group with malignant effusions were significantly higher compared to the group with benign effusion (Ppleural effusions were 97.7. CONCLUSION All of these tumor markers can be helpful for differential diagnosis of pleural *** mRNA had more clinical value in differentiation of the pleural efffusions. CA19-9 is unfit to be as an optimal *** combined assay of hTERT mRNA and CEA in pleural effusions can further raise the positive detection rate of the tumor markers and can be helpful in producing a diagnosis.

关键词： pleural effusions hTERT mRNA CEA CA19-9.

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