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Characterization of oral and gut microbiome and plasma metabolomics in COVID-19 patients after 1-year follow-up

Military Medical Research 2023年第2期10卷 162-174页

作者： Guang-Ying Cui Ben-Chen Rao Zhao-Hai Zeng Xue-Mei Wang Tong Ren Hai-Yu Wang Hong Luo Hong-Yan Ren Chao Liu Su-Ying Ding Jun-Jie Tan Zhen-Guo Liu Ya-Wen Zou Zhi-Gang Ren Zu-Jiang Yu Department of Infectious Diseases the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Gene Hospital of Henan Province/Precision Medicine Center the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Infectious Diseases Guangshan County People’s HospitalGuangshan CountyXinyang 465450HenanChina Department of Breast Surgery Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450052China Shanghai Mobio Biomedical Technology Co. LtdShanghai 201111China Health Management Center the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Background:Due to the outbreak and rapid spread of coronavirus disease 2019(COVID-19),more than 160 million patients have become convalescents worldwide to *** alterations have occurred in the gut and oral microbiome and metabonomics of patients with ***,it is unknown whether their characteristics return to normal after the 1-year ***:We recruited 35 confirmed patients to provide specimens at discharge and 1 year later,as well as 160healthy controls.A total of 497 samples were prospectively collected,including 219 tongue-coating,129 stool and 149 plasma ***-coating and stool samples were subjected to 16S rRNA sequencing,and plasma samples were subjected to untargeted metabolomics ***:The oral and gut microbiome and metabolomics characteristics of the 1-year convalescents were restored to a large extent but did not completely return to *** the recovery process,the microbial diversity gradually *** acid-producing microbes and Bifidobacterium gradually increased,whereas lipopolysaccharideproducing microbes gradually *** addition,sphingosine-1-phosphate,which is closely related to the inflammatory factor storm of COVID-19,increased significantly during the recovery ***,the predictive models established based on the microbiome and metabolites of patients at the time of discharge reached high efficacy in predicting their neutralizing antibody levels one year ***:This study is the first to characterize the oral and gut microbiome and metabonomics in 1-year convalescents of *** key microbiome and metabolites in the process of recovery were identified,and provided new treatment ideas for accelerating *** the predictive models based on the microbiome and metabolomics afford new insights for predicting the recovery situation which benefited affected individuals and healthcare.

关键词： Coronavirus disease 2019(COVID-19) Gut microbiome Oral microbiome plasma metabonomics Convalescents Individual outcomes Patient stratifcation Predictive Preventive and personalized medicine(3PM)

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Quercetin Attenuates Atherosclerosis via Modulating Apelin Signaling Pathway Based on plasma Metabolomics

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Chinese Journal of Integrative Medicine 2023年第12期29卷 1121-1132页

作者： LIU Li-qun ZHANG Peng QI Ying-zi LI Hui JIANG Yue-hua YANG Chuan-hua The First Clinical Medical College Shandong University of Traditional Chinese MedicineJinan(250355)China College of Integrated Chinese and Western Medicine Binzhou Medical UniversityYantaiShandong Province(264000)China Health College Shandong University of Traditional Chinese MedicineJinan(250355)China Department of Pharmacy Ruijin HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai(200050)China Central Laboratory Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan(250014)China Department of Cardiovascular Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan(250014)China

Objective:To interpret the pharmacology of quercetin in treatment of atherosclerosis(AS).Methods:Fourteen apolipoprotein E-deficient(ApoE^(-/-))mice were divided into 2 groups by a random number table:an AS model(ApoE^(-/-))group and a quercetin treatment group(7 in each).Seven age-matched C57 mice were used as controls(n=7).Quercetin[20 mg/(kg·d)]was administered to the quercetin group intragastrically for 8 weeks for pharmacodynamic *** morphological observation,the distribution of CD11b,F4/80,sirtuin 1(Sirt1)and P21 was assayed by immunohistochemistry and immunofluorescence to evaluate macrophage infiltration and tissue ***-performance liquid chromatography/tandem mass spectrometry(UPLC-MSC/MS)was performed to study the pharmacology of quercetin against ***,simultaneous administration of an apelin receptor antagonist(ML221)with quercetin was conducted to verify the possible targets of *** proteins in apelin signaling pathway,such as angiotensin domain type 1 receptor-associated proteins(APJ),AMP-activated protein kinase(AMPK),peroxisome proliferator-activated receptor-γcoactivator-1α(PGC-1α),tissue plasminogen activator(TPA),uncoupling protein 1(UCP1)and angiotensinⅡreceptor 1(AT1R),were assayed by Western ***:Quercetin administration decreased lipid deposition in arterial lumen and improved the morphology of ApoE^(-/-)aortas in *** decreased the densities of CD11b,F4/80 and P21 in the aorta and increased the level of serum apelin and the densities of APJ and Sirt1 in the aorta in ApoE^(-/-)mice(all Pplasma metabolite profiling identified 118 differential metabolites and showed that quercetin affected mainly glycerophospholipids and fatty *** analysis suggested that the apelin signaling pathway was one of the main *** treatment increased the protein expressions of APJ,AMPK,PGC-1α,TPA and UCP1,while decreased the AT1R level(all P<0.05).After the apelin pathway was

关键词： quercetin atherosclerosis plasma metabonomics apelin signaling pathway

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