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Tetramethylpyrazine and paeoniflorin combination(TMP-PF)alleviates atherosclerosis progress by reducing hyperlipemia and inhibiting plaque angiogenesis via the NR4A1/VEGFR2 pathway

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Food Science and Human Wellness 2024年第5期13卷 2642-2652页

作者： Rong Yuan Qiqi Xin Weili Shi Yu Miao Zhengchuan Zhu Yahui Yuan Ying Chen Xiaoning Chen Sean Xiao Leng Keji Chen Weihong Cong Cardiovascular Diseases Laboratory Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China National Clinical Research Center for Chinese Medicine Cardiology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China School of Health Economics and Management Nanjing University of Chinese MedicineNanjing 210023China Department of Otolaryngology Jiangsu Province Hospital of Chinese MedicineNanjing 210029China Division of Geriatric Medicine and Gerontology Department of MedicineJohns Hopkins University School of MedicineBaltimore 21224United States

Atherosclerosis remains a great threat to human health *** studies found that tetramethylpyrazine(TMP)and paeonifl orin(PF)combination(TMP-PF)exerts anti-atherosclerotic effects in ***,whether TMP-PF improves atherosclerosis in vivo needs further *** present study aims to assess the anti-atherosclerotic properties of TMP-PF in ApoE^(-/-)mice and explore the related molecule *** showed that TMP and high-dose TMP-PF decreased serum triglyceride and low-density lipoprotein cholesterol levels,suppressed vascular endothelial growth factor receptor 2(VEGFR2)and nuclear receptor subfamily 4 group A member 1(NR4A1)expression in aortic tissues,inhibited plaque angiogenesis,reduced plaque areas,and alleviated atherosclerosis in ApoE^(-/-)***,TMP-PF exhibited a better modulation effect than TMP or PF ***,NR4A1 agonist abolished the anti-atherosclerotic effects of *** conclusion,TMP-PF was first found to alleviate atherosclerosis progression by reducing hyperlipemia and inhibiting plaque angiogenesis via the NR4A1/VEGFR2 pathway,indicating that TMP-PF had a positive effect on reducing hyperlipemia and attenuating atherosclerosis development.

关键词： Atherosclerosis Hyperlipemia Angiogenesis plaque stability Chinese medicine Tetramethylpyrazine Paeoniflorin

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p-Cresyl sulfate promotes the formation of atherosclerotic lesions and induces plaque instability by targeting vascular smooth muscle cells

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Frontiers of Medicine 2016年第3期10卷 320-329页

作者： Hui Han Yanjia Chen Zhengbin Zhu Xiuxiu Su Jingwei Ni Run Du Ruiyan Zhang Wei Jin Department of Cardiology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Institute of Cardiovascular Diseases Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

Coronary atherosclerosis is a major complication of chronic kidney disease. This condition contributes to the increased mortality in dialysis patients.p-Cresyl sulfate （PCS） is a prototype of protein-bound uremic toxins that cannot be efficiently removed through routine dialysis procedures. In the present study, ApoE/- mice that underwent 5/6 nephrectomy were randomly divided into two groups, namely, vehicle-treated group （n = 20） and PCS-treated group （n = 20）. Mice were sacrificed for en face and immunohistological analyses after 8 or 24 weeks of high-fat diet. Rat aortic vascular smooth muscle cells （VSMCs） were treated with phosphate buffer solution or 500 ltmol/L PCS for in vitro evaluation. PCS-treated mice were observed to suffer increased atherosclerotic lesions after eight weeks of PCS administration. Moreover, 24 weeks of PCS administration also markedly increased the vulnerability index of aortic plaques. PCS was also observed to facilitate the migration and proliferation of VSMCs during the progression of the disease. Moreover, PCS disturbed the balance between matrix metalloproteinases and tissue inhibitor of metalloproteinases within the plaques. Thus, PCS played a vital role in promoting atherogenesis and disturbing the stability of formed plaques probably by targeting VSMCs.

关键词： p-cresyl sulfate atherosclerosis plaque stability vascular smooth muscle cell

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Pathogenic role of microRNAs in atherosclerotic ischemic stroke:Implications for diagnosis and therapy

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Genes & Diseases 2022年第3期9卷 682-696页

作者： Qidi Jiang Yiran Li Quanli Wu Li Huang Jiasheng Xu Qingfu Zeng Department of Biomedicine Queen Mary University of LondonNanchangJiangxi 330006PR China Department of Clinical Laboratory The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006PR China Department of Vascular Surgery The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006PR China School of Public Health Nanchang UniversityNanchangJiangxi 330001PR China

Ischemic stroke resulting from atherosclerosis(particularly in the carotid artery)is one of the major subtypes of stroke and has a high incidence of *** lipid homeostasis,lipid deposition,local macrophage infiltration,smooth muscle cell proliferation,and plaque rupture are the main pathological processes of atherosclerotic ischemic ***,macrophages,endothelial cells and vascular smooth muscle cells are the main cell types participating in these *** inhibiting the expression of the target genes in these cells,microRNAs play a key role in regulating lipid disorders and atherosclerotic ischemic *** this article,we listed the microRNAs implicated in the pathology of atherosclerotic ischemic stroke and aimed to explain their pro-or antiatherosclerotic *** article provides an update on the potential diagnostic use of miRNAs for detecting growing plaques and impending clinical ***,we provide a perspective on the therapeutic use of local microRNA delivery and discuss the challenges for this potential therapy.

关键词： Atherosclerotic ischemic stroke ECs Macrophages miRNA plaque stability VSMCs

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