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plant-derived secondary metabolites as the main source of efflux pump inhibitors and methods for identification

Journal of Pharmaceutical Analysis 2020年第4期10卷 277-290页

作者： Armel Jackson Seukep Victor Kuete Lutfun Nahar Satyajit DSarker Mingquan Guo Key Laboratory of plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical GardenChinese Academy of SciencesWuhanChina Sino-Africa Joint Research Center Chinese Academy of SciencesWuhanChina Unit of Research in Microbiology and Antimicrobial Substances/Laboratory of Cancer Research Faculty of ScienceDepartment of BiochemistryUniversity of DschangDschangCameroon Laboratory of Growth Regulators Institute of Experimental Botany ASCR&PalackýUniversitySlechtitelu 2778371OlomoucCzech Republic Centre for Natural Products Discovery School of Pharmacy and Biomolecular SciencesLiverpool John Moores UniversityLiverpoolL33AFUnited Kingdom

The upsurge of multiple drug resistance(MDR)bacteria substantially diminishes the effectiveness of antibiotic arsenal and therefore intensifies the rate of therapeutic failure.The major factor in MDR is efflux pump-mediated resistance.A unique pump can make bacteria withstand a wide range of structurally diverse compounds.Therefore,their inhibition is a promising route to eliminate resistance phenomenon in bacteria.Phytochemicals are excellent alternatives as resistance-modifying agents.They can directly kill bacteria or interact with the crucial events of pathogenicity,thereby decreasing the ability of bacteria to develop resistance.Numerous botanicals display noteworthy efflux pumps inhibitory activities.Edible plants are of growing interest.Likewise,some plant families would be excellent sources of efflux pump inhibitors(EPIs)including Apocynaceae,Berberidaceae,Convolvulaceae,Cucurbitaceae,Fabaceae,Lamiaceae,and Zingiberaceae.Easily applicable methods for screening plant-derived EPIs include checkerboard synergy test,berberine uptake assay and ethidium bromide test.In silico highthroughput virtual detection can be evaluated as a criterion of excluding compounds with efflux substrate-like characteristics,thereby improving the selection process and extending the identification of EPIs.To ascertain the efflux activity inhibition,real-time PCR and quantitative mass spectrometry can be applied.This review emphasizes on efflux pumps and their roles in transmitting bacterial resistance and an update plant-derived EPIs and strategies for identification.

关键词： Multidrug-resistant bacteria Efflux pump inhibitors plant secondary metabolites Edible plants Efflux activity assays

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Like or dislike:Response of rodents to the odor of plant secondary metabolites

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Integrative Zoology 2017年第5期12卷 428-436页

作者： Sabine C.HANSEN Caroline STOLTER Christian IMHOLT Jens JACOB Julius-Kühn Institute for plant Protection in Horticulture and Forests Vertebrate ResearchMünsterGermany University Hamburg Biocenter Grindel and Zoological MuseumHamburgGermany

Rodents,including common voles(Microtus arvalis)and house mice(Mus musculus)cause immense pre-harvest and post-harvest losses.Therefore,developing methods that mitigate these losses while maintaining their role in ecosystems is a priority.Several plant secondary metabolites(PSM)which significantly reduce food intake of both species under laboratory conditions have been identified.However,before these can be used in rodent pest management,they must be tested under more natural conditions where other food sources are available.In this study,the odors of 4 PSMs were evaluated for their repellent effects in experiments conducted in semi-natural enclosures.Soil treated with PSMs or untreated soil(experimental control)was placed in an underground box containing food(rolled oats).We quantified the number of visits to each box and could demonstrate that all 4 PSMs reduced the number of visits to treatment boxes in both rodent species.For common voles the combination of methyl nonyl ketone+black pepper oil was the most repellent PSM.House mice made fewer visits to all PSM boxes;boxes with the anthraquinone were visited least.Furthermore,house mice consumed less food from boxes containing soil treated with all 4 PSMs.Our results suggest that PSMs are repellent in murid and microtine rodents under semi-field conditions.In addition,the future use of PSM odors for repelling both pest species,especially house mice,seems promising.Further investigations with other PSMs,different concentrations as well as alternative application methods are needed to repel common voles from attractive crops.

关键词： enclosure trials odor plant secondary metabolites repellents rodents

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Genomics Grand for Diversified plant secondary metabolites

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植物分类与资源学报 2011年第1期33卷 53-64页

作者： Xin FANG Chang-Qing YANG Yu-Kun WEI Qi-Xia MA Lei YANG Xiao-Ya CHEN plant Science Research Center Shanghai Chenshan Botanical Garden Shanghai 201602 China Institute of plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200032 China

plants can generate an overwhelming variety of structurally diversified organic compounds called secondary metabolites. These compounds usually perform interesting biological activities and important functions in influencing interactions between plants and other organisms. They are also widely utilized as pharmaceuticals, insecticides, dyes, flavors and fragrances. plant genome sequencing, transcriptome and metabolome analyses have provided huge amounts of data to explain the great diversity of secondary metabolites. This knowledge in turn will help us better understand their ecological role and is a creating novel tool for genetic engineering of plant secondary metabolism

关键词： plant secondary metabolites Biosynthetic pathways Genomics Chemical diversity Bioinformatics

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Bioactivity Determination and Control Effect Evaluation of Three plant secondary metabolites against Semiaphis heraclei

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plant Diseases and Pests 2021年第4期12卷 1-4,8页

作者： Panpan Sun Luyao Huang Min Li Longtai Ju Yumeng Wu Jia Li College of Pharmaceutical Science Shandong University of Traditional Chinese MedicineJinan 250355China

[Objective] The paper was to clarify the bioactivity of trans-2-hexenal,oregano oil and thyme oil against Semiaphis heraclei and the synergistic effect of orange peel essential oil and organosilicon on the aphidicidal activity of the three agents.[Method] With S.heraclei,the dominant species of aphids in Lonicera japonica thunb.,as the test insect,the bioactivity and control effect were evaluated by the method of leaf dipping and foliar spraying.[Result] The indoor toxicity of thyme oil was the highest,with the LC_(50) of 1.793 mg/L.Adding additives significantly increased the toxicity of the agents to S.heraclei.Among them,trans-2-hexenal+OSi,oregano oil+OSi and thyme oil+OSi had obvious synergistic effects,with the toxicity coefficients of 1.80,1.48 and 1.45,respectively.Field test showed that the corrected control effect of thyme oil was the highest after con-ventional spraying,and the toxicities of the three agents were higher than that of the control group at 7 d post spraying.Under the condition of 20%reduction of three agents and adding organosilicon,the control effect was increased by about 10% at 1 d post spraying,which was higher than that of the control group at 4 d post spraying,and reached over 98% at 14 d post spraying.[Conclusion] Thyme oil has the highest toxicity and control effect on S.heraclei.Three agents combined with organosilicon have the obvious effect of reducing the quantity and increasing the efficiency,which has the potential for further development.

关键词： Lonicera japonica Semiaphis heraclei plant secondary metabolites Additive

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Cradle for the newborn Monochamus saltuarius:Microbial associates to ward off entomopathogens and disarm plant defense

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Insect Science 2023年第4期30卷 1165-1182页

作者： Si-Xun Ge Jia-Xing Li Zhuo-Heng Jiang Shi-Xiang Zong Li-Li Ren Bejing Key Laboratory for Forest Pest Control Bejing Forestry UniversityBeijingChina School of Science Westlake UniversityHangzhouChina Sino-French Joint Laboratory for Invasive Forest Pests in Eurasia Bejing Forestry University-French National Research Institute for AgricultureFood and Environment(INRAE)BejingChina

The Japanese pine sawyer,Monochamus saltuarius,as a beetle vector of Bur-saphelenchus xylophilus(pine wood nematode),is an economically important forest pest in Eurasia.To feed on the phloem and xylem of conifers,M.saltuarius needs to overcome various stress factors,including coping with entomopathogenic bacteria and also various plant secondary compounds(PSCs).As an important adaptation strategy to colonize host trees,M.saltuarius deposit eggs in oviposition pits to shield their progeny.These pits har-bor bacterial communities that are involved in the host adaptation of M.saltuarius to the conifers.However,the composition,origin,and functions of these oviposition pit bacteria are rarely understood.In this study,we investigated the bacterial community associated with M.saltuarius oviposition pits and their ability to degrade PSCs.Results showed that the bacterial community structure of M.saltuarius oviposition pits significantly differed from that of uninfected phloem.Also,the oviposition pit bacteria were predicted to be enriched in PSC degradation pathways.The microbial community also harbored a lethal strain of Serratia,which was significantly inhibited.Meanwhile,metatranscriptome anal-ysis indicated that genes involved in PSCs degradation were expressed complementarily among the microbial communities of oviposition pits and secretions.In vitro degrada-tion showed that bacteria cultured from oviposition pits degraded more monoterpenes and flavonoids than bacteria cultured from uninfected phloem isolates.Disinfection of ovipo-sition pits increased the mortality of newly hatched larvae and resulted in a significant decrease in body weight in the early stages.Overall,our results reveal that M.saltuarius construct oviposition pits that harbor a diverse microbial community,with stronger PSCs degradation abilities and a low abundance of entomopathogenic bacteria,resulting in the increased fitness of newly hatched larvae.

关键词： community structure entomopathogenic bacteria host plant adaptation plant secondary metabolites symbiotic bacteria

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Nitric oxide:A potential key point of the signaling network leading to plant secondary metabolite biosynthesis

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Progress in Natural Science:Materials International 2007年第12期17卷 1397-1404页

作者： Xu Maojun(Department of Biotechnology, Zhejiang Gongshang University, Hangzhou 310035, China) Department of Biotechnology Zhejiang Gongshang University Hangzhou 310035 China

The endogenous signaling network of plants plays important roles in mediating the exogenous factor-induced biosynthesis of secondary metabolites. Nitric oxide (NO) has emerged as a key signaling molecule in plants recently. Numerous studies demonstrated that the main signaling molecules such as salicylic acid (SA), jasmonic acid (JA), reactive oxygen species (ROS), and NO were not only involved in regulating plant secondary metabolite biosynthesis but also interacted to form a complex signaling network by mutual inhibition and/or synergy. The recent progress in the signal network of plant secondary metabolite biosynthesis has been discussed in this paper. Furthermore, we propose a hypothetical model to show that NO might act as a potential molecular switch in the signaling network leading to plant secondary metabolite biosynthesis.

关键词： plant secondary metabolites biosynthesis signaling network nitric oxide salicylic acid jasmonic acid reactive oxygen species.

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AGRONOMIC AND ENVIRONMENTAL BENEFITS OF REINTRODUCING HERB-AND LEGUME-RICH MULTISPECIES LEYS INTO ARABLE ROTATIONS:A REVIEW

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Frontiers of Agricultural Science and Engineering 2022年第2期9卷 245-271页

作者： Emily C.COOLEDGE David R.CHADWICK Lydia M.J.SMITH Jonathan R.LEAKE Davey L.JONES School of Natural Sciences Bangor UniversityGwyneddLL572UWUK National Institute of Agricultural Botany Huntingdon RoadCambridgeCB 3 OLEUK plants Photosynthesis and SoilUniversity of SheffieldSheffieldS102TNUK Centre for Sustainable Farming Systems Food Futures InstituteMurdochWA 6150Australia

Agricultural intensification and the subsequent decline of mixed farming systems has led to an increase in continuous cropping with only a few fallow or break years,undermining global soil health.Arable-ley rotations incorporating temporary pastures(leys) lasting 1–4 years may alleviate soil degradation by building soil fertility and improving soil structure.However,the majority of previous research on arable-ley rotations has utilized either grass or grassclover leys within ungrazed systems.Multispecies leys,containing a mix of grasses,legumes,and herbs,are rapidly gaining popularity due to their promotion in agri-environment schemes and potential to deliver greater ecosystem services than conventional grass or grass-clover leys.Livestock grazing in arable-ley rotations may increase the economic resilience of these systems,despite limited research of the effects of multispecies leys on ruminant health and greenhouse gas emissions.This review aims to evaluate previous research on multispecies leys,highlighting areas for future research and the potential benefits and disbenefits on soil quality and livestock productivity.The botanical composition of multispecies leys is crucial,as legumes,deep rooted perennial plants(e.g.,Onobrychis viciifolia and Cichorium intybus) and herbs(e.g.,plantago lanceolata) can increase soil carbon,improve soil structure,reduce nitrogen fertilizer requirements,and promote the recovery of soil fauna(e.g.,earthworms) in degraded arable soils while delivering additional environmental benefits(e.g.,biological nitrification inhibition and enteric methane reduction).Multispecies leys have the potential to deliver biologically driven regenerative agriculture,but more long-term research is needed to underpin evidence-based policy and farmer guidance.

关键词： bioactive forages integrated crop-livestock systems nitrogen cycling plant secondary metabolites soil carbon soil quality

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Global Change Effects on plant Chemical Defenses against Insect Herbivores

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Journal of Integrative plant Biology 2008年第11期50卷 1339-1354页

作者： M.Gabriela Bidart-Bouzat Adebobola Imeh-Nathaniel Department of Biological Sciences Bowling Green State University

This review focuses on individual effects of major global change factors, such as elevated CO2, O3, UV light and temperature, on plant secondary chemistry. These secondary metabolites are well-known for their role in plant defense against insect herbivory. Global change effects on secondary chemicals appear to be plant species-specifc and dependent on the chemical type. Even though plant chemical responses induced by these factors are highly variable, there seems to be some specificity in the response to different environmental stressors. For example, even though the production of phenolic compounds is enhanced by both elevated CO2 and UV light levels, the latter appears to primarily increase the concentrations of flavonoids. Likewise, specific phenolic metabolites seem to be induced by O3 but not by other factors, and an increase in volatile organic compounds has been particularly detected under elevated temperature. More information is needed regarding how global change factors influence inducibility of plant chemical defenses as well as how their indirect and direct effects impact insect performance and behavior, herbivory rates and pathogen attack. This knowledge is crucial to better understand how plants and their associated natural enemies will be affected in future changing environments.

关键词： elevated CO2 global climate change insect herbivory ozone plant chemical defenses plant-insect interactions plant secondary metabolites temperature tri-trophic interactions UV light.

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Impact of the Glucosinolate Sinigrin on Bacterial Communities in Pieris rapae

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Advances in Microbiology 2016年第8期6卷 566-573页

作者： Leslie M. McKinnon Courtney J. Robinson Department of Biology Howard University Washington DC USA

Dynamics in animal-associated microbiota can be difficult to study due to community complexity. Previous work showed that microbial communities in the midguts of Pieris rapae larvae contain relatively few members. In this study, we used P. rapae to test hypotheses related to how diet impacts gastrointestinal microbiota. More specifically, we investigated how the concentration of sinigrin, a glucosinolate in the natural diet of this insect, alters microbial community structure. Larvae were fed either sterile wheat germ diet alone or amended with 3.0 mg/ml, 6.0 mg/ml, or 9.0 mg/ml of sinigrin. In order to determine shifts in the gut microbial community, 16S rRNA genes from midguts were subjected to pyrosequencing and analyzed. Sinigrin had a significant impact on microbial communities in fourth instar P. rapae larvae, but this was dependent on concentration. The predominant phyla in all treatment groups were Proteobacteria and Firmicutes. Significant difference in beta diversity was typically observed when sinigrin 6 mg/ml and the control treatment groups were compared. The impact of sinigrin on the structure of the midgut microbiota is dependent on concentration, but not in a linear fashion. This may indicate that types and concentrations of glucosinolates have varied impact on midgut microbial community.

关键词： Microbiota Glucosinolates plant secondary metabolites

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