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Efficacy of Curcumin on Cognitive Function Scores in Women with Premenstrual Syndrome and Dysmenorrhea: A Triple-Blind, placebo-controlled clinical trial

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Chinese Journal of Integrative Medicine 2023年第5期29卷 387-393页

作者： Afsane Bahrami Amir Masoud Jafari-Nozad Samira Karbasi Malaksima Ayadilord Gordon A.Ferns clinical Research Development Unit of Akbar Hospital Mashhad University of Medical SciencesMashhadIran Student Research Committee Birjand University of Medical SciencesBirjandIran Cardiovascular Diseases Research Center Birjand University of Medical SciencesBirjandIran Brighton&Sussex Medical School Division of Medical EducationFalmerBrightonSussex BN19PHUK

Objective: To assess the efficacy of a curcumin supplementation on cognitive abilities in women suffering from premenstrual syndrome(PMS) and dysmenorrhea. Methods: A randomized, triple-blind, placebocontrolled trial was conducted from December 2019 to March 2020. A total of 124 women who had both PMS and dysmenorrhea were enrolled, and were equally and randomly assigned to the curcumin group or placebo group, 62 cases in each. Each subject received either a capsule containing 500 mg of curcuminoid, or a placebo daily, for 10 days(7 days before and until 3 days after the onset of menstrual bleeding) over 3 menstrual cycles. The cognitive abilities questionnaire was used to measures cognitive functions in 7 specific areas. Adverse reactions were monitored during and after the trial in both groups. Results: Administration of curcumin was associated with a significant increase in memory score(P=0.002), inhibitory control and selective attention(P=0.020), and total cognitive ability task(P=0.024). In addition, significant increments were found in scores of memory(3.5±3.1 vs. 0.4±3.8 in the curcumin and placebo groups, respectively;P=0.035), inhibitory control and selective attention(3.0±3.7 vs. 0.4±3.7;P=0.027) and total cognitive abilities(8.3±12.3 vs. 2.2±12.4;P=0.025) in the curcumin group versus placebo groups. Curcumin was safe and well-tolerable in current clinical trial. Conclusion: Curcumin has a beneficial efficacy on cognitive function scores in women with PMS and dysmenorrhea, with improvements in memory, inhibitory control and selective attention.(Registration No. IRCT20191112045424N1, available at: https://***)

关键词： curcumin memory cognition dysmenorrheal premenstrual syndrome triple-blind placebo-controlled clinical trial

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PRELIMINARY FINDINGS OF AN EVALUATION OF THE EFFECTIVENESS OF LASER ACUPUNCTURE ON OSTEOARTHRITIC KNEE PAIN:A RANDOMISED, DOUBLE-BLIND, placebo-controlled clinical trial

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Journal of Integrative Medicine 2014年第3期 318-318页

作者： Meikin Rees Tapan Rai Peter Meier

Background: Worldwide, osteoarthritis(OA) is the major cause of musculoskeletal pain and mobility disability in elderly *** Arthritis Research Society International(OARSI) lists acupuncture among 35 evidence-based consensus recommendations for the management of OA of the knee or ***: The objective of this randomised, double-blind, placebo-controlled trial is to evaluate the effectiveness of LASER acupuncture on osteoarthritis knee(OAK) *** study integrates traditional acupuncture philosophy, treatment principles and techniques with modern LASER technology.A literature review suggests LASER-related OA research has focused primarily on the general condition rather than OAK *** published research is available on LASER acupuncture *** OAK research did not use a design that accounts for the TCM model, although 9 out of 10 OAK studies produced positive ***: Forty participants have been recruited and screened against inclusion/exclusion criteria and randomized into two groups: intervention and *** or placebo will be administered 3 times per week for 4 weeks(12 treatments).Outcome measures will be evaluated before and after the 12 treatments, with 1 and 2 months *** will be tested for statistical significance using ANOVA and t *** study is differentiating itself from earlier studies by using TCMspecific inclusion criteria in addition to the Kellgren-Lawrence ***: Forty participants have taken part in this study, the first of its type in *** the study outcome is, new knowledge will be developed within the field of LASER acupuncture where currently very little information has been published.

关键词： placebo-controlled clinical trial PRELIMINARY FINDINGS OF AN EVALUATION OF THE EFFECTIVENESS OF LASER ACUPUNCTURE ON OSTEOARTHRITIC KNEE PAIN DOUBLE-BLIND

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