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Treatment of pituitary prolactinomas with bromocriptine

Treatment of pituitary prolactinomas with bromocriptine

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中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Xiangdong Li, Guozhen Hui Department of Neurosurgery, the First Hospital Affiliated to Suzhou University, Su Zhou 215006, China

Objective: Clinical effects and mechanisms of bromocriptine treatment on pituitary prolactinomas were explored in this clinical and pathological study. Method: Twenty-six patients with prolactinomas were selected. Bromocriptine was administrated in 16 patients before operation, while 7 patients were not treated with bromocriptine before operation. Tumor specimens were resected during operation and examined under a light microscope and an electron microscope. Three cases of giant adenoma were only treated with bromocriptine, and changes in tumor volume were observed. Results: In 16 cases with bromocriptine treatment, the cell size decreased while karyoplasmic ratio increased. Observation under an electron microscope revealed that secretory granules, mitochondria, and rough endoplasmic reticulum were markedly reduced. When treated with bromocriptine for a long period, margination of the nuclear chromatin occurred. Some chromatin detached from the nuclear membrane and spread into the cytoplasm in a budding manner forming an apoptotic body. Some tumor cells exhibited vacuolar degeneration, necrosis, or autolysis. In patients who received only bromocriptine treatment, the tumor volume decreased by 98.52%. Conclusion: Bromocriptine could cure prolactinomas. The main underlying mechanism was that bromocriptine could induce apoptosis and secondary necrosis of tumor cells.

关键词： bromocriptine pituitary prolactinomas apoptosis

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