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pituitary carcinoma: Two case reports and review of literature

World Journal of Clinical Oncology 2020年第2期11卷 91-102页

作者： Lai Xu Karam Khaddour Jie Chen Keith M Rich Richard J Perrin Jian Li Campian Divisions of Hematology and Oncology Department of MedicineWashington University School of MedicineSt.LouisMO 63110United States Department of Pathology and Immunology Washington University School of MedicineSt.LouisMO 63110United States Department of Neurological Surgery Washington University School of MedicineSt.LouisMO 63110United States

BACKGROUND pituitary carcinoma is a rare type of malignancy that can be very difficult to diagnose and *** cases were diagnosed at *** in diagnosis often adversely impact patients’*** with prompt diagnosis,treatment decisions remain challenging in the absence of randomized controlled *** SUMMARY We report two cases of pituitary carcinoma in men with a history of pituitary *** the first case,a 55-year-old man was initially diagnosed with pituitary *** underwent subtotal debulking of the tumor followed by adjuvant ***,he developed relapsed disease and multifocal intracranial metastases and a diagnosis of pituitary carcinoma was *** passed away despite several lines of systemic therapies including temozolomide,lomustine and *** 52-year-old man was diagnosed with atypical pituitary adenoma with presentation of sudden onset of vision loss in the right *** had recurrent pituitary carcinoma with spinal metastases,treated with surgery,radiation and *** pituitary carcinoma is a rare neoplasm with poor prognosis that is difficult to diagnose and *** small number of cases restricts our ability to design randomized clinical *** is largely driven by retrospective studies and case *** molecular biomarkers and comprehensive genomic profiling could help in decisions about diagnosis and management of pituitary carcinoma.

关键词： pituitary carcinoma Diagnosis Treatment pituitary adenoma Temozolomide Case report

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ELEVATED SOLUBLE EPIDERMAL GROWTH FACTOR RECEPTOR LEVEL IN pituitary ADENOMA AND carcinoma

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Chinese Medical Sciences Journal 2004年第3期19卷 199-202页

作者： Yan-guoKong Zu-yuanRen Chang-baoSu Ren-zhiWang Wen-bingMa WeiLian LaboratoryofNeurosurgery PekingUnionMedicalCollegeHospitalChineseAcademyofMedicalSciences＆PekingUnionMedicalCollegeBeijing100730

To investigate effect of the soluble epidermal growth factor receptor (sEGFR/sErbB1) level in the periph-eral blood in development, invasiveness, apoplexy of each type of pituitary tumor. Methods The sEGFR level was determined in peripheral serum from 190 patients with pituitary diseases by enzyme linked immunosobent assay. The sEGFR levels were measured in 10 pituitary Rathke’s pouch, 18 pituitary hyperplasia, 161 pituitary adenomas including 30 microadenomas, 83 large adenomas, 48 giant adenomas, 1 pituitary carcinoma, and 28 hea-lthy controls. Results In the patients with pituitary hyperplasia, microadenoma, large adenoma, giant adenoma, and pituitary carci-noma, the sEGFR level was 188.92 ± 32.62, 209.83 ± 19.01, 333.20 ± 69.33, 405.85 ± 37.38, and 617.45 fmol/mL indepen-dently. They were all significantly higher than patients with pituitary Rathke’s pouch (156.78 ± 18.24 fmol/mL, P pituitary carcinoma was higher than pi-tuitary adenoma. In patients with pituitary adenoma, the sEGFR level was positive correlated to the size of pituitary adeno-mas (r = 0.998), the significant difference was observed for the sEGFR level in each group of the patients with pituitary adenomas (P pituitary ACTH-secreting microadenomas, the serum sEGFR levels in invasiveness (295.00 ± 77.80 fmol/mL) was higher than that in non-invasiveness (210.60 ± 16.4 fmol/mL, P pituitary ACTH-secreting, PRL-secreting, GH-secreting, and non-functioning large adenomas, the serum sEGFR levels in invasiveness (407.86 ± 28.50, 399.25 ± 30.10, 386.00 ± 13.08, and 369.25 ± 36.70 fmol/mL) was higher than that in non-invasiveness (335.25 ± 63.49, 300.64 ± 47.57, 297.00 ± 61.93, and 269.30 ± 25.68 fmol/mL) respectively (P pituitary PRL-secreting, GH-secreting, and non-functioning giant adenomas, the serum sEGFR levels n

关键词： pituitary adenoma pituitary carcinoma soluble epidermal growth factor receptor

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