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Influences of oscillation on the physical stability and explosion characteristics of solid-liquid mixed fuel

Defence Technology（防务技术） 2024年第10期40卷 191-198页

作者： Chi Zhang Ge Song Hui Guo Jiafan Ren Chunhua Bai Beijing Aerospace Propulsion Institute Beijing 100076China State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

The stratification phenomenon resulting from differences in the physical properties of solid-liquid components seriously affect the final combustion and explosion characteristics of mixed fuel under the action of *** effects of oscillation on the physical stability of mixed fuel with two solid-liquid ratios and three liquid component distribution ratios have been investigated using a self-designed experimental system at oscillation frequencies of 60-300 r/*** explosion characteristics of mixed fuel before and after oscillation are gained from a 20 L spherical explosion container *** the mass ratio of liquid components is controlled at 66.9%,64.7%,62.6%the final explosion characteristics are stable,with a maximum difference of only 0.71%.The volume of liquid fuel precipitation increases with increasing oscillation frequency when the mass ratio of liquid components reaches 71.7%,69.6%,67.7%.The fuel explosion overpressure after oscillation decreases with increasing liquid precipitation volume,and the repeatability is poor,with a maximum standard deviation of 82.736,which is much higher than the ratio without *** controlling the mass ratio of liquid components of the mixed fuel can effectively combat the impact of oscillation on the physical state and maintain the stability of the final explosion characteristics.

关键词： Solid-liquid mixed fuel physical stability Explosion characteristics

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Effect of Polyisobutylene Succinimide on the physical stability of an Environmentally Friendly Pesticide Oil Dispersion Suspension

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Journal of Renewable Materials 2023年第6期11卷 2679-2694页

作者： Liying Wang Junzhi Liu Chong Gao Xinxin Yan Institute of Functional Molecules Shenyang University of Chemical TechnologyShenyang110142China

Oil dispersible suspension concentrates are safe,green,and environmentally friendly *** such as layering,pasting,and bottoming are frequently encountered during the production,storage,and transportation *** succinimide functions as a dispersant and exhibits great potential to improve the physical stability of the oil dispersible suspension *** a microscopic perspective,the sorption characteristics of the polyisobutylene succinimide dispersant T151 on penoxsulam particle surfaces were comprehensively evaluated with XPS,FTIR,and *** T151 adsorption procedure complied with a pseudo-second-order kinetic adsorption model,and it was a kind of physical sorption with an Ea of 22.57 kJ⋅mol^(−1).The T151 sorption model was consistent with the Langmuir *** adsorption process was spontaneous and followed by an entropy ***ΔH^(θ)of dispersant T151 on the surface of penoxsulam particles was 31.59 kJ⋅mol^(−1).The adsorption procedure was endothermic,and the primary force was hydrogen *** XPS results showed that the F and S electronic peaks at the penoxsulam interface decreased,and that the C electronic peak increased significantly after the adsorption of dispersant T151,indicating the adsorption on the surface of penoxsulam *** results of this study provide a vital theoretical basis for the application of polyisobutylene succinimide dispersants in oil dispersible suspension systems.

关键词： Polyisobutylene succinimide oil dispersion suspension penoxsulam physical stability

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Physico-Chemical and Microbiological Study for the stability of Phenytoin Sodium Extemporaneously Compounded Suspension in Saudi Arabia Hospitals

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Pharmacology & Pharmacy 2021年第1期12卷 1-9页

作者： Syed Ata ur Rahman Abdullah Alsaedi Abdulelah Alhusayni Abdulmalik Alqurshi Sameh Ahmed Yaser M. Alahmadi Alaa Omer M. Abdullaal Badr Ahmed A. Taher El-Sayed E. Habib Department of Pharmaceutics and Pharmaceutical Technology College of Pharmacy Taibah University Madinah Munawwarah Kingdom of Saudi Arabia Department of Pharmacy College of Health Sciences and Nursing AlRayan College Madinah Munawwarah Kingdom of Saudi Arabia Department of Pharmacognosy and Pharmaceutical Chemistry College of Pharmacy Taibah University Madinah Munawwarah Kingdom of Saudi Arabia Department of Clinical and Hospital Pharmacy College of Pharmacy Taibah University Madinah Munawwarah Kingdom of Saudi Arabia Pharmacy Department Madinah Maternity and Children Hospital Madinah Munawwarah Kingdom of Saudi Arabia Department of Microbiology and Immunology Faculty of Pharmacy Mansoura University Mansoura Egypt

Epilepsy is a chronic and the fourth most common neurological disorder which affects people of all age groups. Recently research and awareness on epilepsy-related deaths have rapidly grown over the past two decades. Many previous studies are attributed to the guidelines that apprise health care professionals in handling these deaths, but there is a relative scarcity of information accessible for clinicians and pharmacists who are responsible for manufacturing or preparing the extemporaneous anti-epileptic suspensions in the hospitals. Mostly in partial seizures, phenytoin is one of the first-choice drugs. In Saudi Arabian hospitals, the extemporaneous preparation of phenytoin suspension is common, but the hot climatic weather in Saudi Arabia possesses stability problems that should be tackled as the prepared suspension should pass all the stability tests to ensure uniform dosage of the extemporaneous formulation. In the current study, the commercial capsules were used to prepare the oral phenytoin sodium extemporaneous suspension. The physical, chemical and microbiological stability of phenytoin sodium suspension is analyzed at various temperatures.

关键词： physical stability Phenytoin Extemporaneous Preparation Chemical stability Epilepsy

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Computational prediction of solid dispersion formulations by machine learning approaches

Computational prediction of solid dispersion formulations by...

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2019中国化学会第十五届全国计算（机）化学学术会议

作者： Run Han Hui Xiong Zhuyifan Ye Yilong Yang Tianhe Huang Fuzheng Ren 欧阳德方 State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences (ICMS) University of Macau Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology 澳门大学

Amorphous solid dispersion（SD） is an effective solubilization technique for water-insoluble drugs. However, physical stability issue of solid dispersions still heavily hindered the development of this technique. Traditional stability experiments need to be tested at least three to six months, which is time-consuming and unpredictable. In this research, a novel prediction model for physical stability of solid dispersion formulations was developed by machine learning techniques. 646 stability data points were collected and described by over 20 molecular descriptors. All data was classified into the training set（60%）, validation set（20%）, and testing set（20%） by the improved maximum dissimilarity algorithm（MD-FIS）. Eight machine learning approaches were compared and random forest（RF） model achieved the best prediction accuracy（82.5%）. Moreover, the RF models revealed the contribution of each input parameter, which provided us the theoretical guidance for solid dispersion formulations. Furthermore, the prediction model was confirmed by physical stability experiments of 17β-estradiol（ED）-PVP solid dispersions and the molecular mechanism was investigated by molecular modeling technique. In conclusion, an intelligent model was developed for the prediction of physical stability of solid dispersions, which benefit the rational formulation design of this technique. The integrated experimental, theoretical, modeling and data-driven AI methodology is also able to be used for future formulation development of other dosage forms.

关键词： solid dispersion physical stability machine learning molecular modeling

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