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phototriggered structures:Latest advances in biomedical applications

药学学报:英文版 2023年第7期13卷 2844-2876页

作者： Mojtaba Shamsipur Atefeh Ghavidast Afshin Pashabadi Department of Chemistry Razi UniversityKermanshah ***Iran

Non-invasive control of the drug molecules accessibility is a key issue in improving diagnostic and therapeutic *** studies have explored the spatiotemporal control by light as a peripheral *** drug delivery systems(PTDDSs) have received interest in the past decade among biological researchers due to their capability the control drug *** this end,a wide range of phototrigger molecular structures participated in the DDSs to serve additional efficiency and a high-conversion release of active fragments under light *** to now,several categories of PTDDSs have been extended to upgrade the performance of controlled delivery of therapeutic agents based on well-known phototrigger molecular structures like o-nitrobenzyl,coumarinyl,anthracenyl,quinolinyl,o-hydroxycinnamate and hydroxyphenacyl,where either of one endows an exclusive feature and distinct mechanistic *** review conveys the design,photochemical properties and essential mechanism of the most important phototriggered structures for the release of single and dual(similar or different) active molecules that have the ability to quickly reason of the large variety of dynamic biological phenomena for biomedical applications like photo-regulated drug release,synergistic outcomes,real-time monitoring,and biocompatibility potential.

关键词： phototrigger Light irradiation Excited state proton transfer Drug delivery system Dynamic process Controlling chemistry

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Tightening up the structure, lighting up the pathway:application of molecular constraints and light to manipulate protein folding, self-assembly and function

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Science China Chemistry 2014年第12期57卷 1615-1624页

作者： MARKIEWICZ Beatrice N. CULIK Robert M. GAI Feng Department of Chemistry University of Pennsylvania Department of Biochemistry and Biophysics University of Pennsylvania

Chemical cross-linking provides an effective avenue to reduce the conformational entropy of polypeptide chains and hence has become a popular method to induce or force structural formation in peptides and ***,other types of molecular constraints,especially photoresponsive linkers and functional groups,have also found increased use in a wide variety of ***,we provide a concise review of using various forms of molecular strategies to constrain proteins,thereby stabilizing their native states,gaining insight into their folding mechanisms,and/or providing a handle to trigger a conformational process of interest with *** applications discussed here cover a wide range of topics,ranging from delineating the details of the protein folding energy landscape to controlling protein assembly and function.

关键词： protein folding aggregation self-assembly cross-linker phototrigger light-activation

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维普期刊数据库

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Photo-responsive protein labeling with Quantum dots

Photo-responsive protein labeling with Quantum dots

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第八届全国化学生物学学术会议

作者： Chunyan Bao Zhenzhen Liu Linyong Zhu Shanghai Key Laboratory of Functional Materials Chemistry Fine ChemicalsEast China University of Science and Technology

＜正＞QDs（Quantum dots） is an excellent biological probe due to its special features such as broader excitation spectrum,photostability,and high quantum yields,which can be further functionalized with protein ligands or antibodies to label specific cellular ***,we report a new strategy to prepare QDs-based photo-responsive bioconjugates to realize the efficient and fast protein *** the scheme

关键词： Quantum dots Protein labeling phototrigger Thiol-ene click reaction

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