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Black phosphorus quantum dots as multifunctional nanozymes for tumor photothermal/catalytic synergistic therapy

Nano Research 2022年第2期15卷 1554-1563页

作者： Hui Ding Daji Wang Haibing Huang Xiaozhu Chen Jie Wang Jinjie Sun Jianlin Zhang Lu Lu Beiping Miao Yanjuan Cai Kelong Fan Yongtian Lu Hongsong Dong Xiyun Yan Guohui Nie Minmin Liang Shenzhen Key Laboratory of Nanozymes and Translational Cancer Research Department of OtolaryngologyInstitute of Translational MedicineShenzhen Second Peoples Hospital/the First Affiliated Hospital of Shenzhen University Health Science CenterShenzhen 518035China Experimental Center of Advanced Materials School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Key Laboratory of Protein and Peptide Pharmaceuticals Institute of BiophysicsChinese Academy of SciencesBeijing 100101China

Nanozymes are nanomaterials with enzyme-like properties that have attracted significant interest owing to their high stability,easy preparation,and tunable catalytic properties,especially in the field of cancer ***,the unfavorable catalytic effects of nanozymes in the acidic tumor microenvironment have limited their ***,we developed a biomimetic erythrocyte membrane-camouflaged ultrasmall black phosphorus quantum dots(BPQDs)nanozymes that simultaneously exhibited an exceptional near-infrared(NIR)photothermal property and dramatically photothermal-enhanced glucose oxidase(GOx)-like activity in the acidic tumor *** demonstrated the engineered BPQDs gave a photothermal conversion efficiency of 28.9%that could rapidly heat the tumor up to 50℃ while effectively localized into tumors via homing peptide iRGD leading after intravenously ***,the significantly enhanced GOx-like activity of BPQDs under NIR irradiation was capable of catalytical generating massive toxic reactive oxygen species via using cellular *** combining the intrinsic photothermal property and the unique photothermal-enhanced GOx-like catalytic activity,the developed BPQDs were demonstrated to be an effective therapeutic strategy for inhibiting tumor growth in *** believe that this work will provide a novel perspective for the development of nanozymes in tumor catalytic therapy.

关键词： nanozymes black phosphorus quantum dots glucose oxidase-like activity photothermal/catalytic synergistic therapy

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