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Photonic Crystal-Enhanced photodynamic antibacterial therapy

CCS Chemistry 2023年第3期5卷 624-632页

作者： Yujie Gao Xiaodong Chen Miaomiao Li Lianbin Zhang Jintao Zhu Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of EducationSchool of Chemistry and Chemical EngineeringHuazhong University of Science and Technology(HUST)Wuhan 430074

photodynamic antibacterial therapy(PDAT)is a kind of rejuvenating strategy that combats bacterial infection due to its admirable characteristics of noninvasiveness and broad-spectrum antibacterial ***,the efficiency of PDAT can be greatly hindered by limited light ***,we propose an enhanced PDAT by employing photonic composite films(PCFs)via slow photon and multiple scattering *** PCFs are obtained by UV light-initiated polymerization of poly(ethylene glycol)phenyl ether acrylate with a self-assembled SiO_(2)colloidal particle array,followed by the deposition of photosensitizers(PSs).The PCFs can prompt the PSs with matched absorption,which are deposited on their surface,to sufficiently utilize the incident light and generate more reactive oxygen species based on the slow photon phenomenon of photonic crystals and multiple scattering effects of the SiO_(2)colloidal *** finding demonstrates the great potential and significance of PCFs in the field of PDAT,which may reduce the requirements of excitation equipment and avoid damage to normal tissues from exposure to huge light energy.

关键词： photonic crystal photodynamic antibacterial therapy bacterial infection reactive oxygen species photosensitizers

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A new class of nitrobenzoic acid-based AIE photosensitizers for highly efficient photodynamic antibacterial therapy

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Science China Materials 2021年第10期64卷 2601-2612页

作者： Huanhuan Wang Xiaohong Pan Yaqi Wang Wenzhen Liu Tao Dai Binbin Yuan Xueyuan Chen Zhuo Chen State Key Laboratory of Structural Chemistry CAS Key Laboratory of Design and Assembly of Functional NanostructuresFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Chinese Academy of Sciences Beijing 100049China

hotodynamic therapy(PDT)has been drawing more and more attention in the antibacterial *** photosensitizers(PSs)tend to aggregate in aqueous media,which reduces the generation of reactive oxygen species(ROS)and seriously affects the photodynamic *** efforts have been made to prevent aggregation of traditional *** contrast,aggregation-induced emission PSs(AIE-PSs)take advantage of aggregation to boost ROS generation and fluorescence ***,the efficacies of the reported antibacterial AIE-PSs are ***,we report a new class of highly effective antibacterial AIE-PSs based on nitrobenzoic acid ***,a negatively charged AIE-PS,can not only selectively kill spherical bacteria(Staphylococcus aureus(***))rather than rod-shaped bacteria(Escherichia coli(***)),but also be easily extended to several AIE-PSs(TTVBP1–3)with positive charges and broad-spectrum antibacterial *** demonstrate that TTVBP2 can kill3.0 log_(10)of *** at very low concentration(125 nmol L^(-1)),TTVBP3 can kill 4.7 log_(10)of Staphylococcus epidermidis(***)at a concentration of 1μmol L^(-1)and 3.8 log_(10)of *** at 5μmol L^(-1),thus enabling them among the most effective antibacterial AIE-PSs reported so ***,these AIE-PSs exhibit excellent wash-free imaging ability for bacteria by simple mixing with *** thus envision that TTVBA,a nitrobenzoic acid-based extendable AIE-PS,provides a new route for the design of AIE-PSs in antibacterial treatment.

关键词： photodynamic antibacterial therapy photosensitizer aggregation-induced emission reactive oxygen species imaging

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photodynamic eradication of intratumoral microbiota with bacteria-targeted micelles overcomes gemcitabine resistance of pancreatic cancer

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Aggregate 2024年第1期5卷 377-384页

作者： Renfa Liu Huanyu Yang Shuai Qu Peipei Yang Xin Zhi Yunxue Xu Zhifei Dai Linxue Qian Department of Biomedical Engineering College of Future TechnologyNational Biomedical Imaging CenterPeking UniversityBeijingChina Department of Ultrasound Beijing Friendship HospitalCapital Medical UniversityBeijingChina

Increasing evidence suggests that intratumoral microbiota plays a pivotal role in tumor progression,immunosurveillance,metastasis,and ***,in pancreatic ductal adenocarcinoma,tumor-resident Gammaproteobacteria could transform the chemotherapeutic drug gemcitabine(Gem)into its inactive form,thus rendering chemotherapy ***,a strategy for selectively eradicating intratumoral bacteria was described for overcoming Gem resistance in a pancreatic cancer animal *** antimicrobial peptide was linked with photosensitizer through a poly(ethylene glycol)chain,which can self-assemble into micelles with a diameter of∼20 *** micelles could efficiently kill bacteria under light irradiation by inducing membrane depolarization,thereby inhibiting Gem *** a bacteria-resident pancreatic cancer animal model,the selective photodynamic eradication of intratumoral bacteria was demonstrated to efficiently reverse Gem *** research highlights antibacterial photodynamic therapy as a promising adjuvant strategy for cancer therapy by modulating intratumoral microbiota.

关键词： antimicrobial peptide gemcitabine resistance intratumoral microbiota pancreatic ductal adenocarcinoma photodynamic antibacterial therapy

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