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photobiomodulation:a novel approach to promote trans-differentiation of adipose-derived stem cells into neuronal-like cells

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Neural Regeneration Research 2025年第2期20卷 598-608页

作者： Daniella Da Silva Madeleen Jansen van Rensburg Anine Crous Heidi Abrahamse Laser Research Centre Faculty of Health SciencesUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa

photobiomodulation,originally used red and near-infrared lasers,can alter cellular *** has been demonstrated that the visible spectrum at 451-540 nm does not necessarily increase cell proliferation,near-infrared light promotes adipose stem cell proliferation and affects adipose stem cell migration,which is necessary for the cells homing to the site of *** this in vitro study,we explored the potential of adipose-derived stem cells to differentiate into neurons for future translational regenerative treatments in neurodegenerative disorders and brain *** investigated the effects of various biological and chemical inducers on trans-differentiation and evaluated the impact of photobiomodulation using 825 nm near-infrared and 525 nm green laser light at 5 J/*** adipose-derived stem cells can be used in autologous grafting and photobiomodulation has been shown to have biostimulatory *** findings reveal that adipose-derived stem cells can indeed trans-differentiate into neuronal cells when exposed to inducers,with pre-induced cells exhibiting higher rates of proliferation and trans-differentiation compared with the control ***,green laser light stimulation led to notable morphological changes indicative of enhanced trans-differentiation,while near-infrared photobiomodulation notably increased the expression of neuronal *** biochemical analysis and enzyme-linked immunosorbent assays,we observed marked improvements in viability,proliferation,membrane permeability,and mitochondrial membrane potential,as well as increased protein levels of neuron-specific enolase and ciliary neurotrophic ***,our results demonstrate the efficacy of photobiomodulation in enhancing the trans-differentiation ability of adipose-derived stem cells,offering promising prospects for their use in regenerative medicine for neurodegenerative disorders and brain injuries.

关键词： differentiation inducers green photobiomodulation immortalized adipose-derived stem cell near-infrared photobiomodulation neurodegenerative disease neurogenesis photobiomodulation trans-differentiation

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photobiomodulation provides neuroprotection through regulating mitochondrial fission imbalance in the subacute phase of spinal cord injury

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Neural Regeneration Research 2023年第9期18卷 2005-2010页

作者： Xin Li Xuan-Kang Wang Zhi-Jie Zhu Zhuo-Wen Liang Peng-Hui Li Yang-Guang Ma Tan Ding Kun Li Xiao-Shuang Zuo Cheng Ju Zhi-Hao Zhang Zhi-Wen Song Hui-Lin Quan Jia-Wei Zhang Liang Luo Zhe Wang Xue-Yu Hu Department of Orthopedics Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina 2967 Hospital of People’s Liberation Army Joint Logistic Support Force DalianLiaoning ProvinceChina

Increasing evidence indicates that mitochonarial lission imbalance plays an important role in derayed neuronal cell death. Our previous study round that photo biomodulation improved the motor function of rats with spinal cord ***,the precise mechanism remains *** investigate the effect of photo biomodulation on mitochondrial fission imbalance after spinal cord injury,in this study,we treated rat models of spinal co rd injury with 60-minute photo biomodulation(810 nm,150 mW) every day for 14 consecutive *** electron microscopy results confirmed the swollen and fragmented alte rations of mitochondrial morphology in neurons in acute(1 day) and subacute(7 and 14 days) *** biomodulation alleviated mitochondrial fission imbalance in spinal cord tissue in the subacute phase,reduced neuronal cell death,and improved rat posterior limb motor function in a time-dependent *** findings suggest that photobiomodulation targets neuronal mitochondria,alleviates mitochondrial fission imbalance-induced neuronal apoptosis,and thereby promotes the motor function recovery of rats with spinal cord injury.

关键词： low-level laser therapy mitochondria mitochondrial dynamics mitochondrial fission imbalance neuron photobiomodulation secondary injury spinal cord injury

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photobiomodulation for the treatment of retinal diseases: a review

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International Journal of Ophthalmology(English edition) 2016年第1期9卷 145-152页

作者： Ivayla I.Geneva Department of Ophthalmology State University of New York Upstate Medical University Center for Vision Research

photobiomodulation（PBM）,also known as low level laser therapy,has recently risen to the attention of the ophthalmology community as a promising new approach to treat a variety of retinal conditions including agerelated macular degeneration,retinopathy of prematurity,diabetic retinopathy,Leber’s hereditary optic neuropathy,amblyopia,methanol-induced retinal damage,and possibly *** review evaluates the existing research pertaining to PBM applications in the retina,with a focus on the mechanisms of action and clinical *** available literature until April 2015 was reviewed using Pub Med and the following keywords：＂photobiomodulation AND retina＂,＂low level light therapy AND retina＂,＂low level laser therapy AND retina＂,and＂FR/NIR therapy AND retina＂.In addition,the relevant references listed within the papers identified through Pub Med were *** literature supports the conclusion that the low-cost and noninvasive nature of PBM,coupled with the first promising clinical reports and the numerous preclinical-studies in animal models,make PBM well-poised to become an important player in the treatment of a wide range of retinal ***,large-scale clinical trials will be necessary to establish the PBM therapeutic ranges for the various retinal diseases,as well as to gain a deeper understanding of its mechanisms of action.

关键词： photobiomodulation low level lasertherapy age-related macular degeneration retinopathy ofprematurity far-red to near-infrared retinal degeneration amblyopia retinitis pigmentosa methanol toxicity

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photobiomodulation inhibits the expression of chondroitin sulfate proteoglycans after spinal cord injury via the Sox9 pathway

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Neural Regeneration Research 2024年第1期19卷 180-189页

作者： Zhihao Zhang Zhiwen Song Liang Luo Zhijie Zhu Xiaoshuang Zuo Cheng Ju Xuankang Wang Yangguang Ma Tingyu Wu Zhou Yao Jie Zhou Beiyu Chen Tan Ding Zhe Wang Xueyu Hu Department of Orthopedics Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina

Both glial cells and glia scar greatly affect the development of spinal cord injury and have become hot spots in research on spinal cord injury *** cellular deposition of dense extracellular matrix proteins such as chondroitin sulfate proteoglycans inside and around the glial scar is known to affect axonal growth and be a major obstacle to autogenous *** proteins are thus candidate targets for spinal cord injury *** previous studies demonstrated that 810 nm photo biomodulation inhibited the formation of chondroitin sulfate proteoglycans after spinal cord injury and greatly improved motor function in model ***,the specific mechanism and potential targets involved remain to be *** this study,to investigate the therapeutic effect of photo biomodulation,we established a mouse model of spinal cord injury by T9 clamping and irradiated the injury site at a power density of 50 mW/cm~2 for 50 minutes once a day for 7 consecutive *** found that photobiomodulation greatly restored motor function in mice and down regulated chondroitin sulfate proteoglycan expression in the injured spinal *** analysis revealed that photobiomodulation inhibited the expression of proteoglycan-related genes induced by spinal cord injury,and versican,a type of proteoglycan,was one of the most markedly changed *** staining showed that after spinal cord injury,versican was present in astrocytes in spinal cord *** expression of versican in primary astrocytes cultured in vitro increased after inflammation induction,whereas photobiomodulation inhibited the expression of ve ***,we found that the increased levels of p-Smad3,p-P38 and p-Erk in inflammatory astrocytes were reduced after photobiomodulation treatment and after delivery of inhibitors including FR 180204,(E)-SIS3,and SB *** suggests that Sma d 3/Sox9 and MAP K/Sox9 pathways may be involved in the effects of photobiomodulatio

关键词： chondroitin sulfate proteoglycans Erk MAPK P38 photobiomodulation principal component analysis Smad3 Sox9 spinal cord injury versican

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photobiomodulation-MEDIATED PATHW AY DIAGNOSTICS

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Journal of Innovative Optical Health Sciences 2013年第1期6卷 18-28页

作者： TIMON CHENG-YI LIU LING ZHU XIANG-BO YANG Laboratory of Laser Sports Medicine South China Normal University Guangzhou GD 510006P.R.China

Cellular pathways are ordinarily diagnosed with pathway inhibitors,related gene regulation,or fuorescent protein *** are also suggested to be diagnosed with pathway activation modulation of photobiomod ulation(PBM)in this paper.A PBM on a biosystem function depends on whether the biosystem is in its function-specific homeostasis(FSH).An FSH,a negative feedback response for the function to be performed perfectly,is maintained by its FSH-essential subfunctions and its FSH-non-essential subfunctions(FNSs).A function in its FSH or far from its FSH is called a normal or dysfunctional function.A direct PBM may self-adaptatively modulate a dysfunctional function until it is normal so that it can be used to discover the optimum pathways for an FSH to be *** indirect PBM may self adaptatively modulate a dysfunctional FNS of a normal function until the FNS is normal,and the normal function is then upgraded so that it can be used to discover the redundant pathways for a normal function to be upgraded.

关键词： Signal transd uction pathway photobiomodulation homeostasis redundancy

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The additive effects of bioactive glasses and photobiomodulation on enhancing bone regeneration

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Regenerative Biomaterials 2023年第1期10卷 702-712页

作者： Lidong Huang Weiyu Gong Guibin Huang Jingyi Li Jilin Wu Yanmei Dong Department of Cariology and Endodontology Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of OralBiomaterials and Digital Medical DevicesBeijing 100081China

Bioactive glasses(BG)have been generally used in bone defects repair for its good osteoinductivity and ***,the early angiogenesis of BG in the repair of large-sized bone defects may not be sufficient enough to support new bone formation,resulting in the failure of bone ***(PBM)therapy,which is superior on promoting early angiogenesis,may contribute to the angiogenesis of BG and further enhance the repair of bone ***,we applied BG and PBM in combination and preliminarily investigated their additive effects on bone regeneration both in vitro and in *** in vitro results revealed that BG combined with PBM remarkably enhanced human bone marrow mesenchymal stem cells proliferation,osteogenic-related genes expression and mineralization,which was better than applying BG or PBM *** in vivo studies,the histological staining results showed that BG induced new bone formation in the interior of defects and promoted new bone reconstruction at 6 weeks *** micro-computed tomography results further confirmed that BG combined with PBM accelerated bone formation and maturation,improved the speed and quality of bone regeneration,and promoted bone *** conclusion,with the optimum BG and PBM parameters,BG combined with PBM generated additive effects on promoting bone regeneration.

关键词： bioactive glasses photobiomodulation osteogenesis angiogenesis tissue engineering

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Current application and future directions of photobiomodulation in central nervous diseases

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Neural Regeneration Research 2021年第6期16卷 1177-1185页

作者： Muyue Yang Zhen Yang Pu Wang Zhihui Sun Shanghai Jiao Tong University ShanghaiChina Core Facility of West China Hospital ChengduSichuan ProvinceChina Department of Rehabilitation Medicine the Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenGuangdong ProvinceChina Department of Psychosomatic Medicine The People’s Hospital of Suzhou New DistrictSuzhouJiangsu ProvinceChina

photobiomodulation using light in the red or near-infrared region is an innovative treatment strategy for a wide range of neurological and psychological *** can promote neurogenesis and elicit anti-apoptotic,antiinflammatory and antioxidative *** therapeutic effects have been demonstrated in studies on neurological diseases,peripheral nerve injuries,pain relief and wound *** conducted a comprehensive literature review of the application of photobiomodulation in patients with central nervous system diseases in February *** NCBI PubMed database,EMBASE database,Cochrane Library and ScienceDirect database were *** reviewed 95 papers and *** has wide applicability in the treatment of stroke,traumatic brain injury,Parkinson’s disease,Alzheimer’s disease,major depressive disorder,and other *** analysis provides preliminary evidence that PBM is an effective therapeutic tool for the treatment of central nervous system ***,additional studies with adequate sample size are needed to optimize treatment parameters.

关键词： Alzheimer’s disease central nervous system diseases major depressive disorder Parkinson’s disease photobiomodulation stroke traumatic brain injury

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Potential targets and mechanisms of photobiomodulation for spinal cord injury

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Neural Regeneration Research 2023年第8期18卷 1782-1788页

作者： Cheng Ju Yang-Guang Ma Xiao-Shuang Zuo Xuan-Kang Wang Zhi-Wen Song Zhi-Hao Zhang Zhi-Jie Zhu Xin Li Zhuo-Wen Liang Tan Ding Zhe Wang Xue-Yu Hu Department of Orthopedics Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina

As a classic noninvasive physiotherapy,photobiomodulation,also known as low-level laser therapy,is widely used for the treatment of many diseases and has anti-inflammatory and tissue repair *** has been shown to promote spinal cord injury *** our previous study,we found that 810 nm low-level laser therapy reduced the M1 polarization of macrophages and promoted motor function ***,the mechanism underlying this inhibitory effect is not *** recent years,transcriptome sequencing analysis has played a critical role in elucidating the progression of ***,in this study,we performed M1 polarization on induced mouse bone marrow macrophages and applied low-level laser *** sequencing results showed the differential gene expression profile of photobiomodulation regulating macrophage *** analyzed these genes using gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment *** of protein-protein interactions and competing RNA endogenous networks were *** found that photobiomodulation inhibited STAT3 expression through increasing the expression of miR-330-5p,and that miR-330-5p binding to STAT3 inhibited STAT3 *** nitric oxide synthase showed trends in changes similar to the changes in STAT3 ***,we treated a mouse model of spinal cord injury using photobiomodulation and confirmed that photobiomodulation reduced inducible nitric oxide synthase and STAT3 expression and promoted motor function recovery in spinal cord injury *** findings suggest that STAT3 may be a potential target of photobiomodulation,and the miR-330-5p/STAT3 pathway is a possible mechanism by which photobiomodulation has its biological effects.

关键词： competing endogenous RNA inflammatory pathway low-level laser therapy macrophage miR-330-5p neurological function photobiomodulation RNA-seq spinal cord injury STAT3

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Remote photobiomodulation: an emerging strategy for neuroprotection

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Neural Regeneration Research 2019年第12期14卷 2086-2087页

作者： Luke C. Gordon Daniel M. Johnstone Bosch Institute University of Sydney NSW AustraliaDiscipline of Physiology University of Sydney NSW Australia

photobiomodulation (PBM)- the irradiation of cells or tissues with low-intensity red to near-infrared light - is emerging as an effective means of enhancing cell and tissue resilience and repair. As reviewed elsewhere (Gordon et al., 2019), the intracellular effects of PBM appear to be primarily mediated by cytochrome C oxidase, a key enzyme in the mitochondrial respiratory chain and a primary photoacceptor of red to near-infrared light. Absorption of light by cytochrome C oxidase alters its redox state, resulting in increased ATP production, the liberation of nitric oxide and a transient burst in reactive oxygen species.

关键词： Remote photobiomodulation neuroprotection irradiation

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Mitochondria are an important target of photobiomodulation in cardiomyocytes

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BIOCELL 2022年第12期46卷 2637-2644页

作者： XINLU GAO XIUXIU WANG WENWEN ZHANG HANJING LI FAN YANG WENYA MA YU LIU Department of Laboratory Medicine at the Fourth Affiliated Hospital and Department of Pharmacy at the Second Affiliated HospitalHarbin Medical UniversityHarbin150081China Department of Pharmacology(State-Province Key Laboratories of Biomedicine-Pharmaceutics of China Key Laboratory of Cardiovascular ResearchMinistry of Education)at College of PharmacyHarbin Medical UniversityHarbin150081China Northern Translational Medicine Research and Cooperation Center Heilongjiang Academy of Medical SciencesHarbin Medical UniversityHarbin150081China

photobiomodulation(PBM)has been shown to delay the pathological process of heart failure,but the exact mechanism of action is not *** occupy one-third of the volume of mammalian cardiomyocytes(CMs)and are central transport stations for CM energy ***,in this study,we explored the regulatory effects of 630 nm light-emitting diodes(LED-Red)on the mitochondria of *** results show that LED-Red-based PBM promotes adenosine triphosphate(ATP)synthesis by upregulating the expression of glycolipid metabolizing ***,there was an improvement in the activity of succinate dehydrogenase(SDH),a key enzyme in the mitochondrial electron transport chain,and the mitochondrial membrane ***,LED-Red affected the state of mitochondrial oxidative stress and promoted the generation of reactive oxygen species(ROS),but the increased ROS production did not damage the *** addition,mitochondrial division and fusion were also affected by the stimulation of ***,PBM treatment led to a significant increase in transcript levels of mitochondrial transcription factor A(TFAM),which controls the stability of the mitochondrial ***,irradiation with LEDs at 630 nm played a regulatory role in mitochondrial function,suggesting that mitochondria appear to be the recipients of PBM *** study provides more insights into the mechanisms underlying PBM treatment in heart diseases.

关键词： photobiomodulation Light-emitting diodes Cardiomyocytes Mitochondrial homeostasis

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