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photoacoustic-immune therapy with a multi-purpose black phosphorus-based nanoparticle

Nano Research 2020年第12期13卷 3403-3415页

作者： Fanchu Zeng Huan Qin Liming Liu Haocai Chang Qun Chen Linghua Wu Le Zhang Zhujun Wu Da Xing MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou510631China Guangdong Provincial Key Laboratory of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou510631China

Effective therapeutic strategies to precisely eradicate primary tumors with minimal side effects on normal tissue,inhibit metastases,and prevent tumor relapses,are the ultimate goals in the battle against cancer.We report a novel therapeutic strategy that combines adjuvant black phosphorus nanoparticle-based photoacoustic(PA)therapy with checkpoint-blockade immunotherapy.With the mitochondria targeting nanoparticle,PA therapy can achieve localized mechanical damage of mitochondria via PA cavitation and thus achieve precise eradication of the primary tumor.More importantly,PA therapy can generate tumor-associated antigens via the presence of the R848-containing nanoparticles as an adjuvant to promote strong antitumor immune responses.When combined with the checkpoint-blockade using anti-cytotoxic T-lymphocyte antigen-4,the generated immunological responses will further promote the infiltrating CD8 and CD4 T-cells to increase the CD8/Foxp3 T-cell ratio to inhibit the growth of distant tumors beyond the direct impact range of the PA therapy.Furthermore,the number of memory T cells detected in the spleen is increased,and these cells inhibit tumor recurrence.This proposed strategy offers precise eradication of the primary tumor and can induce long-term tumor-specific immunity.

关键词： photoacoustic therapy mitochondrial targeting black phosphorus immunotherapy checkpoint blockade

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Specific photoacoustic cavitation through nucleus targeted nanoparticles for high-efficiency tumor therapy

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Nano Research 2020年第3期13卷 719-728页

作者： Yuan Wang Guangle Niu Shaodong Zhai Wenjia Zhang Da Xing MOE Key Laboratory cf Laser Life Science&Institute of Laser Life Science South China Normal UniversityGuangzhou 510631China College of Biophotonics South China Normal UniversityGuangzhou 510631China Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute cf Physics and ChemistryChinese Academy of SciencesBeijing 100190China Department of Pharmacology&Pharmacy Li Ka Shing Faculty of MedicineThe University of Hong Kongt PokfulamHong KongChina

As a new type of cancer treatment,photoacoustic(PA)therapy is based on PA shockwave for rapid,selective and effective killing of cancer cells.The nucleus has been widely used as a target for tumor therapy,which has obtained a very considerable therapeutic effect.In situ destruction of tumor cell nucleus by photoacoustic therapy has not been studied.In this paper,a highly efficient nucleus-targeted photoacoustic theranostic polymer was developed for fluorescence and photoacoustic dual-mode imaging-guided PA therapy.The prepared polymer consists of nucleus targeting TAT peptide(TAT:YGRKKRRQRRR),hydrophilic chain poly(N,N-dimethylacrylamide)(PDMA),and near-infrared(NIR)light absorbing agent(hCyR),which can self-assemble to form nanoparticles of approximately 28 nm(denoted as TAT-PDMA-hCyR NPs).The designed nanoparticles show excellent nucleus targeting and tumor cell death(up to 80%)caused by DNA damage under pulsed laser irradiation compared to non-nucleus target counterpart PDMA-hCyR NPs without TAT peptide in vitro.As expected,the fluorescence and PA dual-mode imaging observed that TAT-PDMA-hCyR NPs were able to passively target and enrich in tumors,providing an experimental basis for in vivo treatment and thus ensuring a significant tumor inhibition rate(about 92%).In conclusion,this study provides a new and practicable method for the development of nucleus-targeting nanoparticles as potential theranostic agent for in vivo cancer imaging and therapy.

关键词： photoacoustic therapy nucleus near-infrared light targeted therapy

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Indocyanine green loaded graphene oxide for high-e±cient photoacoustic tumor therapy

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Journal of Innovative Optical Health Sciences 2016年第4期9卷 47-54页

作者： Baoyun Yan Huan Qin MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science College of Biophotonics South China Normal University Guangzhou 510631 P.R.China

photoacoustic therapy,using the photoacoustic efect of agents for selectively kling tumor cells,has shown pronising for treat ing tumor.Utilization of high optical absorption probes can help to effectively improve the photoacoustic ther apy efficiency.Herein,we report a novel high-absorpt:ion photoacoustic probe that is composed of indocyanine green(ICG)and gr aphene oxide(GO),entitled GO-ICG,for photoacoustic ther apy.The attached ICG with narrow absorption spectral profile has strong optical absorption in the infrared region.The absorption spectrum of the GO-ICG solution reveals that the GO-ICG particles exhibited a 10-fold higher absorbance at 780 nm(its peak absorbance)as compared with GO.Importantly,ICG's fluorescence is quenched by GO via fuorescence resonance energy transfer.As a result,GO-ICG can high efficiently convert the absorbed light energy to acoustic wave under pulsed laser irradiation.We further demonstrate that GO-ICG can produce stronger photoacoustic wave than the GO and ICG alone.Moreover,we conjugate this contrast agent with integrin 0。As mono dlonal antibody to molecularly target the U87-MG human glioblastoma cells for selective tumor cell killing.Finally,our results testify that the photoacoustic therapy eficiency of GO-ICG is higher than the existing photoacoustic therapy agent.Our work demonstrates that GO-ICG is a high efficiency photo-acoustic therapy agent.This novel photoacoustic probe is likely to be an available candidate for tumor therapy.

关键词： photoacoustic therapy photoacoustic effect tumor therapy

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