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tau protein,phosphorylated tau protein,and beta-amyloid 42 levels in patients with neurodegenerative diseases complicated by cognitive deficits A non-randomized,concurrent,case-control investigation

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Neural Regeneration Research 2009年第11期4卷 951-957页

作者： Radomír Talb Jií Masopust Ctirad Andrys Pavel touraè Jakub Hort Martin Vali Department of Neurology Medical FacultyCharles University and University Hospital in Hradec Kralove Department of Psychiatry Medical FacultyCharles University and University Hospital in Hradec Kralove Institute of Clinical Immunology and Allergology Charles University and University Hospital in Hradec Kralove Department of Neurology Medical FacultyMasaryk University and University Hospital in Brno Department of Neurology Charles University2~(nd) Medical School

BACKGROUND： The differential diagnosis of many neurodegenerative disorders depends primarily on clinical symptoms together with imaging methods. Recently, increased importance has been placed on the use of biomarkers for diagnosing various neurodegenerative disorders. OBJECTIVE： To assess the feasibility of tau-protein, phosphorylated tau-protein, beta-amyloid 42 （Aβ42）, and 14-3-3 protein as biomarkers for diagnosing several neurodegenerative diseases complicated by cognitive deficits. DESIGN, TIME AND SETTING： A non-randomized, concurrent, case-control investigation was performed in three medical centers in the Czech Republic （Department of Neurology at the University Hospital in Hradec Kralove, Department of Neurology at the 2rd Medical Faculty, and the University Hospital Motol） between October 2000 and November 2006. PARTICIPANTS： Eighteen patients with probable AIzheimer＇s disease, 4 patients with Creutzfeldt-Jakob disease, 10 patients with frontotemporal dementia, 9 patients with clinically isolated syndrome suggestive of multiple sclerosis, and 7 patients with multiple sclerosis, as well as 38 race-, nationality-, and age-matched cognitively intact controls, were included in the study. Diagnoses were established based on the following criteria： the criteria for Alzheimer＇s disease proposed by the National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer＇s Disease and Related Disorders Association, WHO criteria for Creutzfeldt-Jakob disease, Neary criteria for frontotemporal dementia, and McDonald＇s criteria for multiple sclerosis. All included patients were confirmed to suffer from various degrees of dementia. METHODS： Enzyme-linked immunosorbent assay was used to measure concentrations of tau-protein, phosphorylated tau-protein, and Aβ42 in cerebrospinal fluid （CSF） samples collected by standard lumbar puncture from each patient. Moreover, 14-3-3 protein was assessed by Western blot in CSF of Creutzfeldt-Jakob disease patients. Cog

关键词： Alzheimer's disease Creutzfeldt-Jakob disease multiple sclerosis beta-amyloid 42 total tau protein phosphorylated tau protein

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Cellular and molecular mechanisms underlying the action of ginsenoside Rg1 against Alzheimer’s disease

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Neural Regeneration Research 2012年第36期7卷 2860-2866页

作者： Xi Li Ming Li Yuan Li Qiankun Quan Juan Wang Department of Geriatrics Second Affiliated HospitalCollege of MedicineXi’an Jiaotong University Department of Encephalopathy Xi’an Electric Power Central Hospital Research Center of Rehabilitation Science and Technology School of Life Science and TechnologyXi’an Jiaotong University Department of Laboratory Medicine Xijing HospitalFourth Military Medical University

Ginsenoside Rgl inhibits oxidation, aging and ce this study, we pretreated rat brain tissue sections I apoptosis, and improves cognitive function. In with ginsenoside Rgl, and established brain slice models of Alzheimer＇s disease induced by okadaic acid. The results revealed that ginsenoside Rgl pretreatment suppressed the increase in phosphorylated tau protein expression induced by incubation with okadaic acid, and reduced brain-derived neurotrophic factor expression. These results suggest that ginsenoside Rgl upregulates brain-derived neurotrophic factor expression and inhibits tau protein phosphorylation in brain slices from a rat model of Alzheimer＇s disease.

关键词： Alzheimer's disease ginsenoside Rgl okadaic acid phosphorylated tau protein brain-derivedneurotrophic factor traditional Chinese medicine neural regeneration

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Cerebrospinal fluid amyloid beta and tau proteins in atypical Parkinsonism: a review

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Neuroimmunology and Neuroinflammation 2020年第2期7卷 120-131页

作者： Vasilios C.Constantinides George P.Paraskevas Fotini Boufidou Mara Bourbouli Panagiotis G.Paraskevas Leonidas Stefanis Elisabeth Kapaki 1st Department of Neurology National and Kapodistrian University of AthensAthensP.C.11528Greece Department of Neurology University of CreteHeraklion 70013Greece Department of Nursing Technological Educational Institute of CreteHeraklion 71500Greece

Progressive supranuclear palsy,corticobasal degeneration,multiple system atrophy and dementia with Lewy bodies are the most common causes of atypical Parkinsonism and enter the differential diagnosis of Parkinson's *** system atrophy,dementia with Lewy bodies and Parkinson's disease are synucleinopathies,whereas progressive supranuclear palsy and corticobasal degeneration are *** cerebrospinal fluid markers have been applied on cohorts of patients with Parkinsonism,with the aim to develop biomarkers for these *** tau(τΤ),phosphorylated tau at threonine 181(τP-181)and amyloid-beta with 42 amino acids(Aβ42)are considered classical biomarkers for Alzheimer's *** aim of the present study is to review the literature regarding these classical cerebrospinal fluid biomarkers in cohorts with Parkinsonism,as well as present data on novel approaches regarding analysis of these proteins.

关键词： Biomarkers cerebrospinal fluid progressive supranuclear palsy corticobasal degeneration multiple system atrophy dementia with Lewy bodies tau protein phosphorylated tau protein amyloid beta

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Role of Notoginsenoside Rg1 in Improving Spatial Cognitive Ability and Lowering Phosphorylation Level of tau protein in AD Model Rats

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Medicinal Plant 2018年第2期9卷 73-77页

作者： Muzhe LI Wenhui WU Zhiping WU Meiling REN Shuxian CHEN Xiaoling GUO Ping WANG Li LIN Cell Biology Laboratory College of Basic MedicineHubei University of Chinese Medicine/Hubei Research Institute of Geriatrics/New Products of TCM Senile Diseases Co-Innovation Center of Hubei Shuiguohu Street Community Health Service Center of Wuchang District

[Objectives] To study the effects and mechanism of notoginsenoside Rg1 on the spatial learning and memory and phosphorylated tau protein in the AD( Alzheimer's Disease) model rat. [Methods]The AD model rat was replicated by injection of Aβ_(25-35) in the left lateral ventricles of SD rats. The low dose( 25 mg/kg),middle dose( 50 mg/kg) and high dose( 100 mg/kg) notoginsenoside Rg1 was used for intragastric administration,respectively,two times every day. After 4 weeks,the Morris water maze test was done to detect the learning and memory capacity,and the immunoblotting,immunohistochemical methods were used to detect the changes in the phosphorylation level and distribution of tau protein in hippocampus of the rats. [Results] After the intracerebroventricular injection of Aβ_(25-35),the learning and memory capacity of the model rats was significantly lower than the learning and memory capacity of the normal control rats. The immunoblotting test results showed that the phosphorylation level of tau protein threonine 231 site( Thr231) in hippocampus was significantly increased,and the nonphosphorylation level was significantly decreased. The morphological testing results showed that the phosphorylation level of tau protein Thr231 of AD model rats was increased markedly in region of DG,CA1 and CA3 of the hippocampus. The intervention of the middle dose notoginsenoside Rg1 could significantly improve the learning and memory capacity of the model rats in Morris water maze. The notoginsenoside Rg1 in three different doses could all reduce the phosphorylation level of tau protein Thr231 in the hippocampal DG,CA1,CA3 regions,and there were no significant differences among the three doses. [Conclusions]The notoginsenoside Rg1 could improve Aβ_(25-35)-induced spatial learning and memory impairment of the AD model rats,and decreased the phosphorylation level of tau protein in hippocampus.

关键词： Notoginsenoside Rg1 Alzheimer’s disease Learning and memory phosphorylated tau protein

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