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Function Analysis of AtPLc6 Regulates Pollen Tube Tip Growth in Arabidopsis thaliana

Function Analysis of AtPLC6 Regulates Pollen Tube Tip Growth...

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中国植物生理学会第十次会员代表大会暨全国学术年会

作者： Juan Du, Min-juan Lan, Li-min Lv, Yan-yun Pan* college of Life Sciences, Hebei Agricultural University, Baoding 071000, china

Pollen development involves complex developmental control of gene expression by the haploid genome[1]. Phosphoinositide-specific phospholipase c is a key role in the phosphoinositide signaling transduction

关键词： Arabidopsis thal iana phospholipase c pollen germination

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Ghrelin enhances the excitability of nigral dopaminergic neurons by activating its receptors and inhibiting potassium channels via PLc/PKc pathway

Ghrelin enhances the excitability of nigral dopaminergic neu...

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中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Li-Min SHI,Xi-Xun DU,Zhi-Qiang QU,Ze-Gang MA,Yu ZHOU,Hong JIANG,Jun-Xia XIE~* Department of Physiology,Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines:Physiology,Medical college of Qingdao University,Qingdao,266071

＜正＞Excitability of dopaminergic neurons in substantia nigra pars compacta（SNc） is associated with neuroprotection and motor *** previously found that ghrelin protected dopaminergic neurons against neurotoxicity by inhibiting apoptosis and attenuating the oxidative ***,its physiological mechanism remains *** this study,using rat brain slices,we observed that ghrelin at physiological concentrations not only increased the spontaneous firing rate of nigral dopaminergic neurons,but also altered their firing from regular pacemaker-like to burst *** evidence suggests that ghrelin enhances the excitability of nigral dopaminergic neurons by activating its receptors（GHS-R1a）/PLc/PKc pathway since D-[Lys3]-GHRP-6,a selective antagonist for GHS-R1a,PLc inhibitor U-73122 or PKc inhibitor GF109203X fully abolished the ghrelin effect;potassium channels are considered to be a final effector of this pathway because tetraethylammol/Lonium chloride totally blocked ghrelin-induced excitability *** significantly altered the mIPScs,indicating that ghrelin also regulates inhibitory synaptic *** order to reveal any role of ghrelin in motor coordination,we examined the effect of ghrelin on animal *** microinjection of ghrelin into the SNc caused contralateral dystonic posturing and attenuated catalepsy elicited by systemic haloperidol administration in vivo. These motor effects may be due to increase of dopamine（DA） release from SNc because intracerebroventricular administration of ghrelin caused increase of DA turnover rate in the ***,the results suggest that ghrelin,as a physiological mediator capable of regulating neuronal excitability,participates in the motor function and neuroprotection in SNc.

关键词： ghrelin dopaminergic neurons cell excitability GHS-R1a phospholipase c mIPScs

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Mechanical Strain regulates osteoblast proliferation through ca2+-caMK-cREB Signal Pathway

Mechanical Strain regulates osteoblast proliferation through...

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第十一届全国钙信号和细胞功能研讨会

作者： Yong Guo Qi Lv Xianqiong Zou Zhixiong Yan Yuxian Yan college of Biotechnology Guilin Medical University Institute of Medical Equipment Academy of Military Medical Sciences Experiment Management center Logistical College of People Armed Police Forces

Objective To investigate effect of mechanical strain on ca-ca MK-cREB signal pathway and proliferation of osteoblasts. Methods Using a four-point bending device, Mc3T3-E1 cells were exposed to mechanical tensile strains of 2500 microstrain(μs) and 5000 μs at 0.5 Hz respectively. The intracellular free ca( [ca]i) and calmodulin activity were assayed by fluorospectrophotometry, ca MK II β, cREB, and phosphorylated(activated) cREB(p-cREB) were assessed by immunoblotting, and cells proliferation was assayed with MTT. Pretreatment with verapamil were carried out to block ca channel and inhibitor U73122 was used to inhibit phospholipase c(PLc). Result Mechanical strains of 2500 μs and 5000 μs for 1 to 10 minutes both increased [ca]i level of the cells. The 2500 μs strain, a periodicity of 1 h/day for 3 days, activated calmodulin, elevated protein level of ca MK IIβand p-cREB and promoted cells proliferation, which were attenuated by pretreatment of verapamil or U73122. The effects of 5000 μs strain on calmodulin, caM K IIβ, p-cREB and proliferation were contrary to 2500 μs strain. conclusions The mechanical strain regulates osteoblasts proliferation through ca-ca MKcREB signal pathway via ca chunnel and PLc/IP3 transduction cascades.

关键词： mechanical strain calcium phospholipase c cAMP response element binding protein proliferation

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Functional Analysis of AtPLc4 in Salt Stress Response of Arabidopsis thaliana

Functional Analysis of AtPLC4 in Salt Stress Response of Ara...

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中国植物生理学会第十次会员代表大会暨全国学术年会

作者： Hai-long Liu, Jing-lei Sun, Li-min Lv, Yan-yun Pan* college of Life Sciences, Hebei Agricultural University, Baoding 071000, china

＜正＞Response to salt stress signal transduction in plant is a huge and complex network, there are many key signal components to deeply understand[1,2]. Phosphatidylinositol-4,5-bisphosphate-specific-phospholipase c ... 详细信息

关键词： Arabidopsis thal iana phospholipase c Salt stress

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