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Meclizine Chloridrate and Methyl-β-Cyclodextrin Associated with Monophosphoester Synthetic phosphoethanolamine Modulating Proliferative Potential in Triple-Negative Breast Cancer Cells

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Journal of Pharmacy and Pharmacology 2019年第7期7卷 408-420页

作者： Manuela Garcia Laveli da Silva Luciana Bastianelli Knop Durvanei Augusto Maria Molecular Biology Laboratory Butantan InstituteSao PauloSPBrazil

Synthetic phosphoethanolamine(Pho-s)is a monophosphoester ester with anti-inflammatory and pro-apoptotic *** chloridrate(MC)is a histamine H1 receptor blocker that is also able to inhibit cellular ***,MC does not inhibit cellular respiration in isolated mitochondria such as antimycin and ***-β-cyclodextrin(MβCD)belongs to theβ-cyclodextrin family,which is capable of removing cholesterol from the plasma *** aim of this study was to evaluate the proliferative effects of meclizine chloridrate and methyl-β-cyclodextrin compounds associated with synthetic phosphoethanolamine in a triple-negative human breast tumor line,MDA-MB-231 Cell viability of the tumor line and normal cells FN1 was evaluated by MTT colorimetric test;the production of free radicals was determined by lipoperoxidation(LPO)test;and the percentage of cell cycle phases and proliferative index was evaluated by flow *** viability demonstrated a significant decrease with the treatments of MβCD,MC and Pho-s associated with *** production of free radicals decreases significantly in all *** addition,a significant increase of DNA fragment and decrease in G0/G1 cell cycle phase were observed in cellular percentage with concentrations of 20 and 30 mM of Pho-s in association with MC and MβCD,respectively.

关键词： Human triple-negative breast cancer MDA-MB-231 synthetic phosphoethanolamine meclizine chloridrate methyl-β-cyclodextrin cell cycle

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Phosphomonoester phosphoethanolamine Induces Apoptosis in Human Chronic Myeloid Leukemia Cells

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Journal of Pharmacy and Pharmacology 2019年第7期7卷 434-450页

作者： Thais de Oliveira Conceicao Manuela Garcia Laveli da Silva Durvanei Augusto Maria Molecular Biology Laboratory Butantan InstituteSao PauloSPBrazil

Background:Leukemia is a type of cancer that starts in the blood or blood-forming *** results from the clonal proliferation of hematopoietic cells in the bone marrow and/or lymphoid tissues,which subsequently reach the peripheral circulation and can infiltrate other *** are many different kinds of leukemia,and treatments are different for each *** leukemia is with a slower growing than acute leukemia but could be just as *** are antitumor analogs,such as synthetic phosphoethanolamine,which is a phosphorylated compound capable of controlling cellular proliferation and inducing apoptosis in several types of tumor ***:K562 and K562-Lucena(MDR+)human chronic myeloid leukemia cells were treated with synthetic phosphoethanolamine(Pho-s).The viability was evaluated by sulforhodamine B(SRB)assay and cell cycle phases,apoptosis,markers expression,and mitochondrial potential were assessed by flow ***:Tumor cells formed clusters in suspension and decreased significantly *** concentrations for IC50%were ***-s treated were 43.1 mM(K562)and 145.9 mM(K562-Lucena MDR+)in a period of 24 ***-s induced changes in the distribution of cell population phases of cell cycle which showed an increase in fragmented DNA and increased markers expression envolved apoptosis pathways a decrease in the G1/G0 ***:Treatment of K562 and K562-Lucena(MDR+)chronic myeloid leukemia cells with Pho-s showed dose and time dependent cytotoxic *** cytotoxicity induced a decrease in proliferative capacity,mitochondrial electrical potential,and consequently release of cytochrome C;inhibition of Bcl-2 family protein expression,increase in pro-apoptotic family members Bad and Bax,dependent on p53 ***:This study presented a significant therapeutic potential of Phos-s in this type of leukemia through the apoptotic effects on tumor cells independently of the molecular resistance

关键词： Chronic myeloid leukemia cells synthetic phosphoethanolamine mitochondrial potential apoptosis cell cycle

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Post-Translational Regulation of FLOWERING LOCUS T Protein in Arabidopsis

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Molecular Plant 2016年第2期9卷 308-311页

作者： Soo-Jin Kim Sung Myun Hong Seong Jeon Yoo Suhyun Moon Hye Seung Jung Ji Hoon Ahn Creative Research Initiatives Department of Life Sciences Korea University Seoul 136-701 Korea

Dear Editor,Here, we report the developmental regulation of proteolytic cleavage of the FLOWERING LOCUS T （FT） protein. FT, a mem- ber of the phosphatidylethanolamine-binding protein （PEBP） family, functions as a florigen or a component of florigen. PEBP binds phosphoethanolamine, and its ligand-binding domain is evolutionarily conserved from bacteria to plants and animals （Schoentgen and Jolles, 1995; Bradley et al., 1996）. PEBPs regulate important signaling pathways to control growth and differentiation （Chautard et al., 2004）. Some animal PEBP homologs undergo post-translational regulation. For example,

关键词： cleavage functions phosphoethanolamine

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