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No Significant Association between PIK3CA Mutation and Survival of Esophageal Squamous Cell Carcinoma:A Meta-analysis

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2017年第3期37卷 462-468页

作者：葛晓晴杨淹正李莎莎侯露任景丽杨鲲鹏法宪恩 department of thoracic surgery the second affiliated hospital of zhengzhou universityZhengzhou 450014China operating room the second affiliated hospital of zhengzhou universityZhengzhou 450014China department of pathology the second affiliated hospital of zhengzhou universityZhengzhou 450014China department of cardiac surgery the second affiliated hospital of zhengzhou universityZhengzhou 450014China

The prognostic value of phosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunit alpha(PIK3CA) in patients with esophageal squamous cell carcinoma(ESCC) is controversial. We aimed to investigate the prognostic significance of PIK3CA mutation in patients with ESCC. EMBASE, Pub Med, and Web of Science databases were systematically searched from inception through Oct. 3, 2016. The hazard ratios(HRs) and 95% confidence intervals(CI) were calculated using a random effects model for overall survival(OS) and disease-free survival(DFS). Seven studies enrolling 1505 patients were eligible for inclusion of the current meta-analysis. Results revealed that PIK3CA mutation was not significantly associated with OS(HR: 0.90, 95% CI: 0.63–1.30, P=0.591), with a significant heterogeneity(I2=65.7%, P=0.012). Additionally, subgroup analyses were further conducted according to various variables, such as types of specimen, the sample size, technique and statistical methodology. All results suggested that no significant relationship was found between PIK3CA mutation and OS in patients with ESCC. For DFS, there was no significant association between PIK3CA mutation and DFS in patients with ESCC(HR: 1.00, 95% CI=0.47–2.11, P=0.993, I2=73.7%). Publication bias was not present and the results of sensitivity analysis were very stable in the current meta-analysis. Our findings suggest that PIK3CA mutation has no significant effects on OS and DFS in ESCC patients. More well-designed prospective studies with better methodology for PIK3CA assessment are required to clarify the prognostic significance of PIK3CA mutation in ESCC patients.

关键词： phosphatidylinositol-4 5-bisphosphate 3-kinase catalytic subunit alpha esophageal squamous cell carcinoma prognosis meta-analysis

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Phosphoinositide and phospholipid phosphorylation and hydrolysis pathways<br/>—Organophosphate and organochlorine pesticides effects<br>

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Advances in Biological Chemistry 2013年第3期3卷 22-35页

作者： Teresa Fonovich Gladis Magnarelli Escuela de Ciencia y Tecnología. Universidad Nacional de San Martín San Martín Buenos Aires Argentina Instituto Multidisciplinario de Investigación y Desarrollo de la Patagonia Norte (IDEPA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) Universidad Nacional del Comahue Neuquén Argentina

Phospholipid and phosphoinositide phosphorylation pathways have been shown to be of crucial importance on producing lipid mediators. The earlier findings reported on lipid molecules playing roles in different metabolic pathways used to assign them the exclusive role of second messenger generators. Several researchers have recently described how direct interaction of phospholipids and phosphoinositides with molecules or organelles, without the need for producing second messenger molecules, is responsible for their mechanism of action. Organophosphate and organochlorine pesticide toxicity mechanisms have been extensively studied in relation to their well known effects on cholinesterase activities and on the alterations of electric activity in the nervous system of different organisms respectively. There is little but consistent evidence that some compounds, including in both groups of pesticides, are also able to interact with phospholipid and phosphoinositide phosphorylation pathways in several organisms and tissues. The present review consists of an actualization of basic research on phospholipid and phosphoinositide phosphorylation and hydrolysis pathways, as well as a description of some reported evidences for the effects of the above mentioned pesticides on them.

关键词： phosphatidylinositol-4 5-biphosphate Phosphoinositide Phospholipid Phosphatidylcholine Organophosphate Pesticides Organochlorine Pesticides

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