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phlorizin alleviates deltamethrin-induced oxidative stress in brine shrimp Artemia

Journal of Oceanology and Limnology 2024年第1期42卷 163-173页

作者： Dandan MA Qingli ZHOU Liying SUI Qingbin GUO Huanhuan LIU Honghe LIANG Zhenjing LI Zhongna SANG School of Food Science and Engineering Tianjin University of Science and TechnologyTianjin 300457China Asian Regional Artemia Reference Center Key Laboratory of Marine Resource Chemistry and Food Technology(TUST)Ministry of EducationTianjin University of Science and TechnologyTianjin 300457China Subtropical Crops Research Institute of Guangxi Zhuang Autonomous Region Nanning 530001China Department of Nutrition and Food Hygiene School of Public HealthTianjin Medical UniversityTianjin 300070China

Deltamethrin(DEL),a commonly used pyrethroid pesticide,results in higher reactive oxygen species(ROS)levels in aquatic animals,which consequently unbalance the redox ***(PHL)is a flavonoid and a natural product promising to prevent or reduce pesticide-induced oxidative *** is a micro-crustacean widely used in marine hatcheries and an experimental aquatic organism for environmental toxicology *** research aimed to evaluate the toxicity of DEL on Artemia and the antioxidative effect of PHL against the *** show that 0.08-mg/mL PHL exerted its antioxidative effects on hatching percentage of the cysts in 24-h incubation and on body length and survival rate of Artemia in 12-d *** 12-d culture,12-,24-,and 36-h DEL exposure showed significant drops in SOD,CAT,and GSH-Px enzyme activities,and significant increases in ROS and malondialdehyde(MDA)levels in Artemia(P<0.05).On the contrary,0.08-mg/mL PHL application improved the enzyme activities and decreased the ROS and MDA levels(P<0.05).Moreover,0.08-mg/mL PHL significantly increased mRNA expression levels of Cu/Zn SOD,CAT,GST,HO-1,NQO1,and Nrf2,and decreased mRNA expression level of Keap1 in the DEL-exposed Artemia(P<0.05).Therefore,DEL is toxic to Artemia,while PHL alleviates DEL-induced oxidative damage by possibly regulating the Nrf2signaling *** study provided a theoretical basis for PHL to reduce pesticide-induced toxicity in aquatic animals.

关键词： Artemia deltamethrin phlorizin oxidative stress

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Evaluation of the binding affinity and antioxidant activity of phlorizin to pepsin and trypsin

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Food Science and Human Wellness 2024年第1期13卷 392-400页

作者： Jing Zhang Lan Tang Xia Hu Zhen Zeng Wen Wu Fang Geng Hui Li Di Wu Meat Processing Key Laboratory of Sichuan Province School of Food and Biological EngineeringChengdu UniversityChengdu 610106China School of Chemical Engineering Sichuan UniversityChengdu 610065China

phlorizin(PHL)is a natural compound with strong antioxidant properties mainly found in *** this paper,the interaction mechanism of PHL with pepsin and trypsin was comparatively evaluated by computer simulation,fluorescence spectra,circular dichroism(CD),and Fourier transform infrared(FT-IR)spectra at a molecular *** spectra showed that PHL quenches the pepsin/trypsin by static *** parameters indicated that PHL binds to pepsin mainly through hydrogen bonds and van der Waals forces,and that of trypsin was electrostatic *** ground state complexes PHL and protease have a moderate affinity of 105 L/mol PHL binds more strongly to trypsin than to *** and FT-IR spectra results showed that pepsin/trypsin decreased theβ-sheet content and slightly changed its secondary structure upon *** experimental results are mutually verified with the predicted computer-aid simulation *** PHL and trypsin binding,the antioxidant capacity of PHL was ***,the antioxidant capacity of PHL was decreased after binding to *** work elucidates the binding of PHL binding mechanisms to pepsin/trypsin and provides useful information for the digestion of PHL to improve the application of PHL in food processing.

关键词： Interaction phlorizin Pepsin Trypsin Antioxidation

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Effect of phlorizin on metabolic abnormalities in Spontaneously Diabetic Torii (SDT) rats

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Open Journal of Animal Sciences 2012年第2期2卷 113-118页

作者： Takeshi Ohta Hisayo Morinaga Takuji Yamamoto Takahisa Yamada Laboratory of Animal Breeding and Genetics Graduate School of Agriculture Kyoto University Kyoto Japan Laboratory of Animal Genetics Graduate School of Science and Technology Niigata University Niigata Japan

The Spontaneously Diabetic Torii (SDT) rat is a novel model for nonobese type 2 diabetes. In this study we investigated the glycolipid metabolic changes with phlorizin-treatment, which inhibits intestinal glucose uptake and renal glucose reabsorption, in male SDT rats. phlorizin (100 mg/kg, b.i.d., s.c.) was administered for 4 weeks to SDT rats from 20 to 24 weeks of age. As a result, phlorizin reduced the development of hyperglycemia and decreased the hemoglobin A1c (HbA1c) levels. In the liver, phlorizin increased mRNA levels of glucokinase, the enzymes related with the glycogen cascade and the proteins associated with lipid metabolism. In conclusion, chronic administration of phlorizin in SDT rats produced a good glycemic control and an improvement in liver function.

关键词： Hyperglycemia phlorizin SDT Rat

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Immune Reactive Ezrin Surface Area Increases in Glomerular Podocytes of STZ Diabetic Rats Precede Their Detachment, Is Prevented by phlorizin But Not by Insulin

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Journal of Diabetes Mellitus 2020年第2期10卷 27-40页

作者： Slava Malatiali Issam Francis Musleeha Chesor Gavin Welsh Moin Saleem Mario Barac-Nieto Departments of Physiology Faculty of Medicine Kuwait University Safat Kuwait Pathology Faculty of Medicine Kuwait University Safat Kuwait University of Bristol Pediatric Nephrology Bristol UK Retired 9443 Hickory Limb Colusmbia MD USA

Glomerular tuft immune reactive Ezrin surface area (EzA) and fraction of EzA to total glomerular tuft area significantly increased, indicating podocyte growth, rounding and altered cytoskeletal interactions at 1 week of STZ diabetes. Podocyte number per glomerulus (WT1+ nuclei) did not change indicating no detachment, but density decreased due to tuft hypertrophy. Treatment with PLZ or Insulin for one week, prevented increase in proteinuria and hyperglycemia but not the decrease in podocyte density. PLZ but not Insulin prevented increase in ezrin positive area in glomeruli and per podocyte. In podocytes in culture neither 25 mM glucose with or without PLZ (2.5 or 25 uM) altered Ezrin expression measured in western blots. In summary, the Ezrin positive glomerular surface area increase seen after 1 week of STZ diabetes, reflects altered podocyte morphology and cytoskeletal interactions, prevented by PLZ but not by insulin. Ezrin area increase preceded podocyte detachment and in podocytes in culture is not associated with increases in podocyte Ezrin protein expression. It is a likely precursor of shape changes in podocytes and of alterd interactions with basement membrane that contribute to detachment and thickening. Glomerular capillary tuft hypertrophy and reduced podocyte density persisted despite PLZ or insulin treatments, independently of levels of glycemia and of proteinuria.

关键词： Diabetes. Hyperglycemia Glomerular Hypertrophy phlorizin Podocyte Density Ezrin

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Phenolic compounds and its antioxidant activities in ethanolic extracts from seven cultivars of Chinese jujube

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Food Science and Human Wellness 2014年第3期3卷 183-190页

作者： Huan-xia Zhao Hai-sheng Zhang Shu-fang Yang Lab.of Fruit and Vegetables Processing College of Food Engineering and Nutritional ScienceShaanxi Normal UniversityXi’an 710062China

Phenolic compounds and its antioxidant activity of extracts from seven cultivars of Chinese jujubes were investigated by high performance liquid chromatography(HPLC)with standards and different antioxidant evaluation methods,such as phosphomolybdenum assay,superoxide radical scavenging activity(SRSA),hydroxyl radical scavenging activity(HRSA),antihemolytic activity and inhibition of lipid peroxidation in rat liver homogenate,*** results showed the components of the extracts are comprised of total phenols and flavonoids,and its content ranges from 454.3 to 1298.9(GAE mg/100 g dry weight).phlorizin,catechin,gallic acid,chlorogenic acid,caffeic acid were the predominant phenolic *** the extracts had significant antioxidant activities either in vitro or in *** analysis indicated that the antioxidant capacities of Chinese jujube extracts demonstrated a good positive relationship with some phenolic acids,which was higher in Xiao and *** results indicated that Xiao and Goutou could be attributed to a potential source of natural antioxidants for food applications.

关键词： Chinese jujube Phenolic compounds Flavonoids Antioxidant activity phlorizin

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Supplementing fibroblast growth factor 2 during bovine oocyte <i>in vitro</i>maturation promotes subsequent embryonic development

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Open Journal of Animal Sciences 2012年第2期2卷 119-126页

作者： Kun Zhang Alan D. Ealy Department of Animal Sciences D. H. Barron Reproductive and Perinatal Biology Research Program University of Florida Gainesville USA Department of Veterinary and Animal Sciences University of Massachusetts at Amherst Amherst USA

The Spontaneously Diabetic Torii (SDT) rat is a novel model for nonobese type 2 diabetes. In this study we investigated the glycolipid metabolic changes with phlorizin-treatment, which inhibits intestinal glucose uptake and renal glucose reabsorption, in male SDT rats. phlorizin (100 mg/kg, b.i.d., s.c.) was administered for 4 weeks to SDT rats from 20 to 24 weeks of age. As a result, phlorizin reduced the development of hyperglycemia and decreased the hemoglo-bin A1c (HbA1c) levels. In the liver, phlorizin increased mRNA levels of glucokinase, the enzymes related with the glycogen cascade and the proteins associated with lipid metabolism. In conclusion, chronic administration of phlorizin in SDT rats produced a good glycemic control and an improvement in liver function.

关键词： Hyperglycemia phlorizin SDT Rat

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Seasonal Variation,Microscopic and Chromatographic Analysis of Leaves in Malus hupehensis:A Protocol for Its Quality Control

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Chinese Herbal Medicines 2013年第2期5卷 145-150页

作者： SHEN Tao XIANG Lan REN Dong-mei WANG Shu-qi YANG Ming-ren LOU Hong-xiang School of Pharmaceutical Sciences Shandong University Linyi Shansong Pharmaceutical Company

Objective To establish a quality control protocol based on microscopic, TLC, and HPLC methods, and to verify the optimal harvesting time for the leaves of Malus hupehensis(LMH). Methods The LMH were pulverized into powder for microscopic identification or TLC and HPLC analysis after ultrasonic extraction with methanol. Seasonal variations of the phlorizin content and average leaf weight were determined by HPLC analysis and weighing up the leaves collected from May to October. Results Microscopic and macromorphologic characteristics have been described for the leaf identification. A qualitative TLC assay and a quantitative HPLC method have been established for the quality control of LMH. phlorizin was selected as a reference marker, which resolved at Rf 0.53 in TLC assay and at 14.0 min in HPLC assay. The content of phlorizin decreased gradually from 17.0% in leaves collected in May to 7.5% in October. The average leaf weight reached the level of 0.6 g in August and maintained until its *** These methods are simple, selective, accurate, and reliable for the quality control of LMH. The period from late August to early September is suggested as the optimal harvesting time of the LMH.

关键词： HPLC Malus hupehensis optimal harvesting time phlorizin quality control TLC

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