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Cyclization Reaction of α-Triazolyl-α, β-unsaturated Ketones with phenyl hydrazine

Chinese Chemical Letters 1998年第11期9卷 979-982页

作者： Guo Feng ZHAO Jun REN Yu Chang LI Gui Yu JIN (Institute of Elemento-Organic Chemistry, National Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071) Inst. of Elemento-Organic Chemistry Natl. Key Lab. Elemento-Organ. Chem. Nankai University Tianjin 300071 China

The reaction of α-triazolyl-α, β-unsaturated ketones with phenyl hydrazine was studied. The result indicated that cyclization took place and new heterocyclic compounds of substituted 4,5-2H-pyrazoles were obtained,... 详细信息

关键词： α β-unsaturated ketones phenyl hydrazine triazole cyclization pyrazoles

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Design and Synthesis of New Compounds Derived from phenyl hydrazine and Different Aldehydes as Anticancer Agents

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International Journal of Organic Chemistry 2022年第1期12卷 28-39页

作者： Mo’men Salem Rezk Ayyad Helmy Sakr Ahmed Gaafer Medicinal Chemistry Department Faculty of Pharmacy Sinai University Northern Sinai Egypt Pharmaceutical Chemistry Department Faculty of Pharmacy Al-Azhar University Cairo Egypt Medical Services Sector Ministry of Intrior Cairo Egypt

In this work we synthesized new derivatives from phenyl hydrazine and series of different Aldehydes (derivatives of benzylidenes). The synthesized compounds contain different aromatic Aldehydes which attached by Benzene ring via hydrazine moiety in glacial acetic acid. These derivatives were characterized by TLC, melting points, Infrared Red, Proton Nuclear Magnetic Resonance, Carbon Thirteen Nuclear Magnetic Resonance and Mass Spectroscopy. Finally, these synthesized derivatives were tested for antiproliferative activity against multiple normal and cancerous cell lines, HepG2 (Liver cancer) and MCF-7 (Breast cancer) cell lines were used for cytotoxic assay.

关键词： phenyl hydrazine Aromatic Aldehydes Benzylidene Synthesis Cytotoxic Assay Anticancer HepG2 and MCF-7

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Design and Synthesis of Some New Oxadiazole Derivatives as Anticancer Agents

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International Journal of Organic Chemistry 2022年第2期12卷 64-74页

作者： Mo’men Salem Rezk Ayyad Helmy Sakr Department of Medicinal Chemistry Faculty of Pharmacy Sinai University Northern Sinai Egypt Department of Pharmaceutical Chemistry Faculty of Pharmacy Al-Azhar University Cairo Egypt

In this work, some new oxadiazole derivatives have been prepared, by reacting phenyl hydrazine and acetic anhydride together, which furnished 2,4-dimethyl-4-phenyloxadiazole. This product was reacted with a series of aromatic aldehydes, to obtain a series of oxadiazole derivatives. These derivatives were characterized by TLC, melting points, infrared red, proton nuclear magnetic resonance, carbon thirteen nuclear magnetic resonance and mass spectroscopy. Finally, these synthetized derivatives were tested for antiproliferative activity by two different cell lines. MCF-7 (Breast cancer cell line) and HepG2 (Liver cancer cell line) were used to assess the antiproliferative activity of the prepared compounds.

关键词： phenyl hydrazine Oxadiazole Aromatic Aldehydes Acetic Anhydride Benzylidene Synthesis Cytotoxic Assay Anticancer HepG2 and MCF-7

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