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Rational Daily Administration Times of Yinchenhao Decoctionin Rats with Jaundice Based on PD/PK

Chinese Herbal Medicines 2012年第2期4卷 150-156页

作者： LV Jun-lan JIN Shi-ying YUAN Hai-long HAN Jin FU Shan-shan JIN Shi-xiao GUO Jing-jing XIAO Xiao-he China Military Institute of Chinese Materia Medica 302 Military HospitalBeijing 100039China School of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611731China

Objective To study the rational daily administration times of Yinchenhao Decoction(YCHD)when it was used to treat experimental jaundice in rats based on pharmacodynamics/pharmacokinetics *** Rats were modeled by 4%1-naphthylisothiocyanate(75 mg/kg)for 48 h,then YCHD was drenched with doses of 0.324 g/kg (extract,calculated with the clinical dosage)once,0.162 g/kg twice,and 0.108 g/kg thrice a day,*** total bile and the flow rate of bile were observed after the first administration;Blood samples collected from the orbital sinus at different intervals were used to investigate the levels of liver enzymes(ALT and AST)and bilirubins (TBIL and DBIL),and determine the concentration of 6,7-dimethoxycoumarin(DME)in the plasma using UPLC at the same time,then we obtained the time-effect and time-dose *** rational daily administration times of YCHD when treating experimental jaundice were determined based on the comprehensive analysis of time-effect and time-concentration *** Within 10 h the total bile of rats which were administered once daily(G1) was 1.65 and 1.33 times higher than that of twice and thrice(G2 and G3)a day,respectively,and the four biochemical indexes(TBIL,ALT,DBIL,and AST)of G1 decreased faster than those of G2 and G3(P<0.05).On the other hand, the blood drug level of DME when administrated once daily could maintain at a higher level for a longer time,and its Cmax and AUC0→t were higher than those of G2 and G3,which might be the main reason why its effect was the most *** It is more appropriate to administrate once daily when YCHD is used to treat jaundice.

关键词： bilirubins 6,7-dimethoxycoumarin jaundice pharmacodynamics/pharmacokinetics Yinchenhao Decoction

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Chinese Herbal Medicines 2012年第1期4卷 74-页

The International Society for Ethnopharmacology is a collaborative, interdisciplinary group of scientists–anthropologists, pharmacists, pharmacologists, ethnobotanists, phytochemists, and others–all fascinated by the study of the local and global use of traditional medicines. Traditional medicinal knowledge has been transferred over

关键词： bilirubins 6,7-dimethoxycoumarin jaundice pharmacodynamics/pharmacokinetics Yinchenhao Decoction

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