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A review on cocrystal of active ingredients in traditional Chinese medicine

Traditional Medicine Research 2023年第4期8卷 1-13页

作者： Xiao-Qin Ma Ye Peng Jian Cui Tong-Xiang Liu School of Pharmacy Minzu University of ChinaBeijing 100081China Key Laboratory of Ethnomedicine Minority of EducationMinzu University of ChinaBeijing 100081China

In the development of new drugs products,especially the development of traditional Chinese medicine active ingredients,solubility and oral bioavailability are the main factors which are restricting the development of new drugs,whereas the physicochemical properties of active ingredients are the key element to affecting these *** cocrystal provides an excellent opportunity to develop new drugs with excellent physical and chemical properties such as melting point,solubility,stability and bioavailability while retaining the pharmacological properties of individuals active pharmaceutical ingredients among pharmaceutical cocrystal *** Chinese herbal medicine has the characteristics of multiple pathways and multiple targets,mainly because it contains many active ingredients,like cocrystals thereof with many *** active ingredients extracted from traditional Chinese herbal medicine have a wide range of pharmacological activities,but most of the active ingredients affect the development of traditional Chinese medicine active ingredients due to their physical and chemical properties such as *** Chinese medicine pharmaceutical cocrystals can not only improve the physical and chemical properties of drugs without changing the internal structure of drugs,so as to provide a new scheme for the development of traditional Chinese medicine active *** paper reviews the research progress of active ingredients of traditional Chinese medicine pharmaceutical *** preparation methods of cocrystals are summarized and the advantages of cocrystals are illustrated with examples.

关键词： pharmaceutical cocrystal active ingredients of traditional Chinese medicine cocrystal production advantages of cocrystal

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