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Science China Chemistry 2007年第2期50卷 276-283页

作者： WANG MingWei,YIN DuanZhi,LI ShiQiang & WANG YongXian Radiopharmaceutical Centre,Shanghai Institute of Applied Physics,Chinese Academy of Sciences,Shanghai 201800,China Radiopharmaceutical Centre Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai China

O-(2-[18F]fluoroethyl) -L-tyrosine([18F]FET) ,a fluorine-18 labeled analogue of tyrosine,has been syn-thesized and biologically evaluated in tumor-bearing mice. The whole synthesis procedure is com-pleted within 50 min. The radiochemical yield is about 40%(no decay corrected) and radiochemical purity more than 97% after simplified solid phase extraction. [18F]FET shows rapid,high uptake and long retention in the tumor as well as low uptake in the brain. The ratios of tumor-to-muscle(T/M) and tumor-to-blood(T/B) of [18F]FET are similar to those of [18F]FDG,but the ratios of tumor-to-brain(T/Br) are 2-3 times higher than that of [18F]FDG. Autoradiography of [18F]FET demonstrates a remarkable accumulation in melanoma with high contrast. It appears to be a probable competitive candidate for melanoma imaging with pet.

关键词： [18F]FET [18F]FDG pet imaging melanoma autoradiography

Reversible addition-fragmentation chain transfer graft polymerization of acrylonitrile onto PE/pet composite fiber initiated by γ-irradiation

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Nuclear Science and Techniques 2015年第2期26卷 32-37页

作者：马垚虞鸣李林繁马红娟王自强李景烨 Innovation Research Institute of TMSR Energy System Shanghai Institute of Applied PhysicsChinese Academy of Sciences University of Chinese Academy of Sciences

Reversible addition-fragmentation chain transfer(RAFT) mediated grafting of acrylonitrile onto Polyethylene/Poly(ethylene terephthalate)(PE/pet) composite fibers was performed using γ-irradiation as the initial source at ambient temperature. Different initial concentrations of 2-cyanoprop-2-yl dithiobenzonate were used as the chain transfer agent. The kinetics of graft polymerization is in accordance with the living RAFT polymerization. The successful grafting of acrylonitrile is proved by Fourier transform infrared spectroscopy *** results of monofilament tensile test show that mechanical properties of the fibers change slightly after grafting. Scanning electronic microscopy images of the fibers show that the surface of RAFT grafted fibers is smoother than that of fibers grafted conventionally.

关键词： RAFT聚合复合纤维接枝聚合链转移剂 pet 丙烯腈傅里叶变换红外光谱分析加成

Prognostic significance of interim ^(18)F-FDG pet/CT SUV reduction associated with Ki67 in patients with diffuse large B-cell lymphoma

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Nuclear Science and Techniques 2014年第2期25卷 40-46页

作者：孙一文赵晋华乔文礼邢岩陈香宋建华 Department of Nuclear Medicine Shanghai First Poeple's HospitalShanghai Jiaotong University

To detect the prognostic significance of interim F-FDG pet/CT SUV(standard uptake value) reduction(△SUV_(max)) associated with Ki67 in patients with diffuse large B cell lymphoma(DLBCL).47 DLBCL patients underwent pet/CT before initiation and after 2-4 cycles of chemotherapy were *** SUV_(max)of the dominant lesions were ***67 positive indices were provided by enzyme-labeled ***17.0 was used for statistical ***_(max) of different groups were compared by t ***-operator characteristic analysis was performed to determine the optimal cutoff *** analyses of PFS(Progression-free survival) were compared using log-rank *** average of △SUV_(max)and △SUV_(max)%were 11.53 and 69.10%,*** optimal cutoff values of △SUV_(max)x and △SUV_(max)%were 11.45 and 82.92%,*** △SUV_(max) and △SUV_(max)%indicated longer PFS(p 55%was revealed to be an indicator of shorter PFS(p = 0.019).Either △SUV_(max)≤11.45 or Ki67>55%was defined as an indicator to poor outcome and scored 1 *** PFS rate was 100%in patients scored 0 point,yet 0%in patients scored 2 *** tended to be shorter along with the score getting higher(p = 0.006).△SUV_(max) and Ki67 positive index were both of significance in DLBCL *** prognostic value may be confirmed when △SUV_(max) was accordant with Ki67.

关键词： B细胞淋巴瘤 pet SUV 预后患者 CT 弥漫性中期

Novel radioligands for imaging sigma-1 receptor in brain using positron emission tomography(pet)

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Acta Pharmaceutica Sinica B 2019年第6期9卷 1204-1215页

作者： Yu Lan Ping Bai Zude Chen Ramesh Neelamegam Michael SPlaczek Hao Wang Stephanie AFiedler Jing Yang Gengyang Yuan Xiying Qu Hayden RSchmidt Jinchun Song Marc DNormandin Chongzhao Ran Changning Wang Athinoula A.Martinos Center for Biomedical Imaging Department of RadiologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMA 02129USA Gordon Center for Medical Imaging Department of RadiologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMA 02129USA Department of Biological Chemistry and Molecular Pharmacology Harvard Medical SchoolBostonMA 02129USA Department of Pharmacy Renmin Hospital of Wuhan UniversityWuhan 430060China

The sigma-1 receptor(σ1R)is a unique intracellular protein.σ1R plays a major role in various pathological conditions in the central nervous system(CNS),implicated in several neuropsychiatric *** ofσ1R in the brain using positron emission tomography(pet)could serve as a noninvasively tool for enhancing the understanding of the disease’s ***,σ1R pet tracers can be used for target validation and quantification in ***,we describe the radiosynthesis,in vivo pet/CT imaging of novelσ1R11C-labeled radioligands based on 6-hydroxypyridazinone,[11C]HCC0923 and[11C]*** radioligands have high affinities toσ1R,with good *** mice pet/CT imaging,both radioligands showed appropriate kinetics and ***,the specific interactions of two radioligands were reduced by compounds 13 and 15(self-blocking).Ofthe two,[11C]HCC0929 was further investigated in positive ligands blocking studies,using classicσ1R agonist SA 4503 andσ1R antagonist PD ***σ1R ligands could extensively decreased the uptake of[11C]HCC0929 in mice ***,the biodistribution of major brain regions and organs of mice were determined in *** studies demonstrated that two radioligands,especially[11C]HCC0929,possessed ideal imaging properties and might be valuable tools for non-invasive quantification ofσ1R in brain.

关键词： σ1R pet Brain imaging 6-Hydroxypyridazinone 11C-labeled radioligand

Animal biodistribution, safety and validation study of dopamine transporter pet imaging agent ^(18)F-FECNT

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Nuclear Science and Techniques 2009年第1期20卷 11-16页

作者： WANG Songpei CHEN Zhengping LI Xiaomin TANG Jie LIU Chunyi ZOU Meifen PAN Donghui LU Chunxiong XU Yuping XU Xijie ZHOU Xingqin JIN Jian The Key Laboratory of Nuclear Medicine Ministry of Health PRC Jiangsu Institute of Nuclear Medicine Wuxi 214063 PR China School of Medicine and Pharmaceutics Jiangnan University Wuxi 214122 PR China

This work was to investigate the pharmacologic characteristics of 18F-FECNT (2β-carbomethoxy-3β- (4-chlorophenyl)-8-(2-[18F]fluoroethyl)nortropane) as a dopamine transporter (DAT) pet imaging agent. Its partition coefficients were determined in n-octanol and phosphate buffer (PB) (pH 7.0 and pH 7.4). 6-Hydroxydopamine (6-OHDA) left-sided lesioned Parkinsonian rats were established and validated by rotational behavior tests. Biodistribution in vivo in mice, autoradiography in normal and hemi-Parkinsonian rat brains, and toxicity test were performed. The results showed that partition coefficients were 34.14 (pH 7.0) and 56.41 (pH 7.4), respectively. Biodistribution exhibited rapid uptake and favorable retention in the mice brains. The major radioactivity was metabolized by the hepatic system. The autoradiography showed that 18F-FECNT was highly concentrated in striatum, and that the left and the right striatal uptake were symmetrical in normal SD rat brains. In left-sided lesioned PD rat brains, the striatal uptake of 18F-FECNT bilaterally decreased in comparison with normal rats. No significant uptake was visible in the 6-OHDA lesioned-sided striatal areas. The results demonstrated that 18F-FECNT binds to DAT was specific. Toxicity trial displayed that the acceptable dose per kilogram to mice was 625 times greater than that to human. These indicate that 18F-FECNT is a potentially safe and useful DAT pet imaging agent in the brain.

关键词： DAT pet ^18F-FECNT PD 原子核

Respiratory motion correction with an improved demons algorithm for pet images

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Chinese Physics C 2012年第10期36卷 1025-1030页

作者：高娟柴培贠明凯刘双全单保慈魏龙 Key Laboratory of Nuclear Analysis Techniques Institute of High Energy Physics Chinese Academy of Sciences Graduate University of Chinese Academy of Sciences

Respiratory motion is a major factor that affects the quality of pet images of the thoracic area. The diaphragm moves about 15–20 mm due to respiratory motion, which substantially degrades the effective spatial resolution of pet. In this paper, a gated acquisition method is used to correct the motion effects. In this method, an improved demons algorithm is proposed to align the gated images. The experimental results show that the quality of pet images is significantly improved when using our improved method and the proposed method has a faster convergence rate than the original demons algorithm.

关键词： motion correction demons algorithm discontinuity pet

A simulation study of a dual-plate in-room pet system for dose verification in carbon ion therapy

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Chinese Physics C 2014年第8期38卷 116-121页

作者：陈泽胡正国陈金达张秀玲郭忠言肖国青孙志宇黄文学王建松 Institute of Modern Physics Chinese Academy of Sciences University of Chinese Academy of Sciences

During carbon ion therapy, lots of positron emitters such as 11C, 15O, 11C are generated in irradiated tissues by nuclear reactions, and can be used to track the carbon beam in the tissue by a positron emission tomography （pet） scanner. In this study, an dual-plate in-room pet scanner has been designed and evaluated based on the GATE simulation platform to monitor patient dose in carbon ion therapy. The dual-plate pet is designed to avoid interference with the carbon beamline and with patient positioning. Its performance was compared with that of four-head and full-ring pet scanners. The dual-plate, four-head and full-ring pet scanners consisted of 30, 60, 60 detector modules, respectively, with a 36 cm distance measurements. Each detector module consisted of a between directly opposite detector modules for dose deposition 24~24 array of 2 mm×2 mm×18 mm LYSO pixels coupled to a Hamamatsu H8500 PMT. To estimate the production yield of positron emitters, a 10 cm×15 cm×15 cm cuboid PMMA phantom was irradiated with 172, 200, 250 MeV/u 12C beams. 3D images of the activity distribution measured by the three types of scanner are produced by an iterative reconstruction algorithm. By comparing the longitudinal profile of positron emitters along the carbon beam path, it is indicated that use of the dual-plate pet scanner is feasible for monitoring the dose distribution in carbon ion therapy.

关键词： hadron therapy pet GATE simulation

Maximum standardized uptake value on pet/CT in preoperative assessment of lymph node metastasis from thoracic esophageal squamous cell carcinoma

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Chinese Journal of Cancer 2014年第4期33卷 211-217页

作者： Amos JM Ela Bella Ya-Rui Zhang Wei Fan Kong-Jia Luo Tie-Hua Rong Peng Lin Hong Yang Jian-Hua Fu Department of Thoracic Surgery Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Department of Nuclear Medicine Sun Yat-sen University Cancer Center Guangdong Esophageal Cancer Institute

The presence of lymph node metastasis is an important prognostic factor for patients with esophageal *** assessment of lymph nodes in thoracic esophageal carcinoma is essential for selecting appropriate treatment and forecasting disease *** emission tomography combined with computed tomography(pet/CT)is becoming an important tool in the workup of esophageal ***,we evaluated the effectiveness of the maximum standardized uptake value(SUVmax)in assessing lymph node metastasis in esophageal squamous cell carcinoma(ESCC)prior to ***-nine surgical patients with pathologically confirmed thoracic ESCC were retrospectively *** patients underwent radical esophagectomy with pathologic evaluation of lymph *** all had18F-FDG pet/CT scans in their preoperative staging *** had a prior history of *** pathologic status and pet/CT SUVmax of lymph nodes were collected to calculate the receiver operating characteristic(ROC)curve and to determine the best cutoff value of the pet/CT SUVmax to distinguish benign from malignant lymph *** node data from 27 others were used for the validation.A total of 323 lymph nodes including 39 metastatic lymph nodes were evaluated in the training cohort,and 117lymph nodes including 32 metastatic lymph nodes were evaluated in the validation *** cutoff point of the SUVmax for lymph nodes was 4.1,as calculated by ROC curve(sensitivity,80%;specificity,92%;accuracy,90%).When this cutoff value was applied to the validation cohort,a sensitivity,a specificity,and an accuracy of 81%,88%,and 86%,respectively,were *** results suggest that the SUVmax of lymph nodes predicts ***,when an SUVmax of 4.1 was used instead of 2.5,FDG-pet/CT was more accurate in assessing nodal metastasis.

关键词：淋巴结肿大 CT扫描食管癌 pet 评估摄取标准计算机断层扫描

Preparation of two triflate precursors for O-(2-[^(18)F] fluoroethyl)-L-tyrosine used in positron emission tomography (pet)

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Science China Chemistry 2009年第12期52卷 2195-2199页

作者： LIU ChunYan1,2 & JIANG ShenDe1 1 School of Pharmaceutical Science and Technology,Tianjin University,Tianjin 300072,China 2 Department of Pharmacy,North China Coal Medical College,Tangshan 063000,China School of Pharmaceutical Science and Technology Tianjin University Tianjin China Department of Pharmacy North China Coal Medical College Tangshan China

Two novel triflate precursors for radiolabelling of L-tyrosine in positron emission tomography (pet) for tumor imaging,O-(2-trifluoromethanesulfonyloxyethyl)-N-(tert-butoxycarbonyl)-L-tyrosine methyl ester 9a and O-(2-trifluoromethanesulfonyloxyethyl)-N-(tert-butoxycarbonyl)-L-tyrosine tert-butyl ester 9b,are synthesized. The triflate agent,9a or 9b,is prepared by esterification of methanol or transesterification of tert-butyl acetate with L-tyrosine,protection of the amine group with di-tert-butyl dicarbonate,alkylation with chlorohydrin,and triflation with trifluoromethanesulfonic anhydride in four steps with overall yields of 30% and 15%,respectively.

关键词： positron emission tomography triflate L-tyrosine [18F]FET precursor pet imaging

Comparison of diagnostic accuracy between ^(18)F-FDG pet and pet/CT for pulmonary neoplasm

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Nuclear Science and Techniques 2009年第1期20卷 17-21页

作者： CHEN Yangchun CHEN Ping TIAN Jiahe CAI Xin YE Guangchun DENG Huaifu YANG Xiaofeng Department of pet/CT Center No.1 Hospital Affiliated to Guangzhou Medical College Guangzhou 510230 China Department of Nuclear Medicine The Chinese PLA General Hospital Beijing 100853 China Department of Nuclear Medicine The People＇s Hospital ofXinjiang UygurAutonomous Region Urumuqi 830001 China

Aimed at comparing diagnostic accuracy of 18F-FDG pet with pet/CT for pulmonary neoplasm, a study based on multi-center clinical trial of the diagnoses, in randomized and semi-blind ways, was executed from January 2006 to June 2007. It included 55 patients, i.e. 16 with histopathologically proved lung tumors, 16 with tuberculosis and 23 with benign lesions (inflammation, pseudotumor, granuloma, fibrosis and others). The histopathologic and clinic results were served as reference standard. Statistical significances in pulmonary nodule diagnosis between 18F-FDG pet and pet/CT were determined with 95% confidence interval obtained by ROC analysis. The 18F-FDG pet detected lung neoplasm with a sensitivity of 87.5% (14/16), a specificity of 59.0% (23/39), an accuracy of 67.3% (37/55) and a positive-likelihood ratio of 2.13. The 18F-FDG pet/CT detected lung neoplasm with a sensitivity of 93.8% (15/16), a specificity of 61.5% (24/39), an accuracy of 70.9% (39/55) and a positive-likelihood ratio of 2.43. The area under curves (AUC) of 18F-FDG pet and pet/CT were 0.803±0.068 and 0.799±0.063, respectively. It can be concluded that the diagnostic accuracy for malignant pulmonary nodules between 18F-FDG pet and pet/CT was not statistically different.

关键词： ^18F-FDG pet CT 核光滑估计方法