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A　Brief　Note　on　Pathogenesis　and　Treatment　of　perthes　disease

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The Journal of Biomedical Research 1994年第1期18卷 25-25页

作者： Fan Weimin, et al. ACTA ACADEMIAE MEDICINAE NANJING, 1994, 14(1):44-46

Measurement of intraosseous pressure in the proximal femur, stress test and venography performed on 49 hips with perthes disease and 38 hips of normal children revealed an increase in intrasoseous pressure in perthes disease group with abnormal stress test and venography. It means that there is venous obstruction in the diseased proximal femur in accompany with raised intraosseous pressure. Core decompression performed on 31 hips with perthes disease gaves good response in 84% of the hips, whereas Chiari pelvic osteotomy done in 18 hips with late stage disease, 77% of the hips improved fairly well. The anthore' opinion is that core decompression is effective for perthes disease in early stage, and the Chiaripelvic osteotomy could be recommended in late stage cases.

关键词： perthes disease intraosseous pressure core decompresslon chiari pelvic osteotomy

Investigation　on　the　Physico－Chemical　Properties　of　Lipiodol　Anticancerous　Chemo－Embolizing　Agents

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The Journal of Biomedical Research 1995年第1期19卷 33-38页

作者：施海彬李麟荪谈恒山

关键词： perthes disease intraosseous pressure core decompresslon chiari pelvic osteotomy

BIOCHEMICAL STUDIES ON GLUCOAMINOGLYCANS CONTENT IN AFFECTED CARTILAGE HYALURONIC ACID LEVELS IN SERUM AND SYNOVIAL FLUID OF IDIOPATHIC FEMORAL HEAD NECROSIS

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Journal of Pharmaceutical Analysis 1999年第2期13卷 162-166,175页

作者： Li Xudong,Wang Kunzheng,Chen Junchang, Li Youfen,Dang Xiaoqian,Pang Wei,Zhu LiDepartment of Orthopaedic Surgery, Second Clinical Medical College of Xi′an Medical University, Xi′an 710004 Department of Orthopaedic Surgery Second Clinical Medical College Xi'an Medical University Xi'an 710004 China

To investigate the role of cartilage alterations in the pathogenesis of the idiopathic femoral head necrosis, 3 components of glycosaminoglycans(GAG) in pathological and health cartilage, levels of hyaluronic acid(HA) in synovial fluid and serum were detected. The correlations among HA level in synovial fluid, serum and GAG content in cartilage were analyzed. The results showed that ①the three components of cartilage GAG in normal adults and children showed little difference; ②Compared with the normal autopsy specimens, steroid induced ANFH and perthes disease specimens had significantly decreased GAG contents (P0 05), but it decreased significantly (P0 05); ③Children suffered from perthes disease had a much higher level of HA in serum than the controls (Pperthes disease. GAG content was positive correlated with HA level in serum of perthes disease, whereas, there was no correlation between them in steroid induced ANFH. The results suggest that:①GAG content in affected hip decreased significantly in the early stage. It provides clinical theory basis for auxiliary treatment to cartilage in early stage; ②Sulfate radical depletion is the most conspicuous one of GAG changes in middle and late stage. It sugges

关键词： glycosaminoglycans hyaluronic acid osteonecrosis femoral head perthes disease