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peroxidase-mimicking evodiamine/indocyanine green nanoliposomes for multimodal imaging-guided theranostics for oral squamous cell carcinoma

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Bioactive Materials 2021年第7期6卷 2144-2157页

作者： Zheng Wei Huihui Zou Gongyuan Liu Chuanhui Song Chuanchao Tang Sheng Chen Guorong Zhang Jianchuan Ran Yufeng Wang Xiteng Yin Yu Cai Wei Han Department of Oral and Maxillofacial Surgery Nanjing Stomatological HospitalMedical School of Nanjing University30 Zhongyang Road210008NanjingChina Clinical Research Institute Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeNo.158 Shangtang RoadHangzhou310014Zhejiang ProvinceChina Pediatric Dentistry Nanjing Stomatology HospitalMedical School of Nanjing UniversityNo 30 Zhongyang RoadNanjing210008China Department of Orthodontics Nanjing Stomatological HospitalMedical School of Nanjing UniversityNo 30 Zhongyang RoadNanjing210008China Central Laboratory of Stomatology Nanjing Stomatological HospitalMedical School of Nanjing University30 Zhongyang Road210008NanjingChina Department of Oral Pathology Nanjing Stomatological HospitalMedical School of Nanjing UniversityNanjingChina Department of Chemistry City University of Hong Kong83 Tat Chee AvenueHong Kong SARChina

Here,evodiamine(EVO)and the photosensitizer indocyanine green(ICG)were integrated into a liposomal nanoplatform for noninvasive diagnostic imaging and combinatorial therapy against oral squamous cell carcinoma(OSCC).EVO,as an active component extracted from traditional Chinese medicine,not only functioned as an antitumor chemotherapeutic agent but was also capable of 68Ga-chelation,thus working as a contrast agent for positron emission tomography/computed tomography(PET/CT)***,EVO could exhibit peroxidase-like catalytic activity,converting endogenous tumor H2O2 into cytotoxic reactive oxygen species(ROS),enabling Chemo catalytic therapy beyond the well-known chemotherapy effect of *** proven by in vitro and in vivo experiments,guided by optical imaging and PET/CT imaging,we show that the theragnostic liposomes have a significant inhibiting effect on in situ tongue tumor through photodynamic therapy combined with chemodynamic chemotherapy.

关键词： Oral squamous cell carcinoma Evodiamine peroxidase-mimicking Trimodal antitumor therapy

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Unusual switchable peroxidase-mimicking nanozyme for the determination of proteolytic biomarker

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Nano Research 2019年第3期12卷 509-516页

作者： Claire McVey Natasha Logan Nguyen T. K. Thanh Christopher Elliott Cuong Cao Institute for Global Food Security School of Biological Sciences Queens University Belfast 18-30 Malone Road Belfast BT9 5BN UK Biophysics Group Department of Physics and Astronomy University College London London WC1E 6BT UK UCL Healthcare Biomagnetic and Nanomaterials Laboratories 21 Albemarle Street London W1S 4BS UK Material and Advanced Technologies for Healthcare Queens University Belfast 18-30 Malone Road Belfast BT9 5BN UK

Detection of enzyme biomarkers originating from either bio-fluids or contaminating microorganisms is of utmost importance in clinical diagnostics and food safety. Herein, we present a simple, low-cost and easy-to-use sensing approach based on the switchable peroxidase-mimicking activity of plasmonic gold nanoparticles (AuNPs) that can catalyse for the oxidation of 3,3’,5’5-tetramethylbenzidine (TMB) for the determination of protease enzyme. The AuNP surface is modified with casein, showing dual functionalities. The first function of the coating molecule is to suppress the intrinsic peroxidase-mimicking activity of AuNPs by up to 77.1%, due to surface shielding effects. Secondly, casein also functions as recognition sites for the enzyme biomarker. In the presence of protease, the enzyme binds to and catalyses the degradation of the coating layer on the AuNP surface, resulting in the recovery of peroxidase-mimicking activity. This is shown visually in the development of a blue colored product (oxidised TMB) or spectroscopically as an increase in absorbance at 370 and 650 nm. This mechanism allows for the detection of protease at 44 ng·mL^-1 in 90 min. The nanosensor circumvents issues associated with current methods of detection in terms of ease of use, compatibility with point-of-care testing, low-cost production and short analysis time. The sensing approach has also been applied for the detection of protease spiked in ultra-heat treated (UHT) milk and synthetic human urine samples at a limit of detection of 490 and 176 ng·mL^-1, respectively, showing great potential in clinical diagnostics, food safety and quality control.

关键词： gold nano particles peroxidase-mimicking nanozyme enzyme detection biomarkers

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Bimetallic AuRu aerogel with enzyme-like activity for colorimetric detection of Fe^(2+) and glucose

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Chinese Chemical Letters 2022年第10期33卷 4683-4686页

作者： Rongxin Xu Ziyu Wang Siquan Liu He Li College of Optoelectronics Technology Chengdu University of Information TechnologyChengdu 610225China School of Chemistry and Chemical Engineering University of JinanJi'nan 250022China

Aerogels have become a hot topic of research due to their extremely low density and special interconnected structure as well as their enzyme-like *** development of new multifunctional nano-enzyme aerogels with high activity and good stability is still a considerable *** this paper,AuRu aerogels with peroxidase and oxidase activities were synthesized using a simple one-step method and successfully used to construct colorimetric sensors for the detection of Fe^(2+)and glucose based on their enzyme-like ***,we are fortunate to find that AuRu aerogels have good photothermal *** suggests that AuRu aerogels can be used not only for in vitro testing but also for promising applications such as disease treatment.

关键词： Au-Ru aerogels Multifunctional nanozyme peroxidase-mimicking Oxidase-like activity Colorimetric detection

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