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Cytoreductive surgery with hyperthermic thoracoabdominal chemotherapy in stage Ⅳ ovarian cancer - a technical description

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Journal of Cancer Metastasis and Treatment 2020年第1期6卷 88-96页

作者： Mukur Dipi Ray Raghuram Kuppusamy Navin Kumar Rakesh Garg Department of Surgical Oncology Dr BRA-IRCHAIIMSNew Delhi 110029India Department of Onco-anesthesiology and Palliative Medicine Dr Dr.B.R.A Institute-Rotary Cancer HospitalAIIMSNew Delhi 110029India

Systemic chemotherapy for peritoneal disease in ovarian carcinoma is associated with a recurrence rate of more than 75%,and most of the cases are confined to the peritoneal *** propensity of locoregional treatment failure has paved the way for the discovery of cytoreductive surgery with intra-cavitary *** surgery(CRS)is the present-day treatment modality for a variety of peritoneal carcinomatosis including ovarian cancer,and multi-visceral resection is critical for completion of *** cases of diaphragmatic infiltration by tumor deposits,partial resection leads to a diaphragmatic rent,which can be used for the perfusion of chemotherapeutic drugs into the pleural *** transmission from the peritoneal to pleural cavity is a poor prognostic factor ***,intrathoracic hyperthermic chemotherapy may be a reasonable treatment option for ovarian carcinoma with malignant pleural effusion or pleural *** intraperitoneal chemotherapy(HIPEC)is added to the treatment plan in cases of complete CRS but this is a technically demanding ***,performing hyperthermic intrathoracic chemotherapy on top of CRS and HIPEC may be even more complicated for such advanced *** technique of combining HIPEC and hyperthermic intrathoracic chemotherapy is also commonly known as hyperthermic thoracoabdominal chemotherapy(HITAC).The perioperative morbidity and mortality may be remarkably high in such *** describe our CRS technique with HITAC,which was performed in three FIGO stage IVA ovarian carcinoma patients with metastatic pleural effusion after complete *** patients were retrospectively identified from a prospectively maintained *** had partial diaphragmatic resection followed by HITAC as part of CRS *** techniques are outlined along with accompanying intra-operative *** demographics,clinical and follow-up details were also described *** comparative analy

关键词： Hyperthermic intraperitoneal chemotherapy hyperthermic intrathoracic chemotherapy ovarian carcinoma cytoreduction surgery peritoneal carcinoma index

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