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Effect of perioperative chemotherapy on resection of isolated pulmonary metastases from colorectal cancer:A single center experience

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3457-3470页

作者： Zhao Gao Xuan Jin Ying-Chao Wu Shi-Jie Zhang Shi-Kai Wu Xin Wang Department of Medical Oncology Peking University First HospitalBeijing 10000China Department of General Surgery Peking University First HospitalBeijing 10000China Department of Thoracic Surgery Peking University First HospitalBeijing 10000China

BACKGROUND Numerous studies have assessed surgical resection as a standard treatment option for patients with colorectal cancer(CRC)and resectable pulmonary metastases(PM).However,the role of perioperative chemotherapy after complete resection of isolated PM from patients with CRC patients remains *** hypothesize that perioperative chemotherapy does not provide significant survival benefits for patients undergoing resection of PM from *** To determine whether perioperative chemotherapy affects survival after radical resection of isolated PM from *** We retrospectively collected demographic,clinical,and pathologic data on patients who underwent radical surgery for isolated PM from *** survival(CSS)and disease-free survival were calculated using Kaplan-Meier ***-group differences were compared using the log-rank *** multivariate analysis,Cox regression was utilized when *** This study included 120 patients with a median age of 61.6 *** 5-year CSS rate was 78.2%,with 36.7% experiencing *** resection for isolated PM resulted in a 5-year CSS rate of 50.0% for second *** chemotherapy(P=0.079)did not enhance survival *** associated with improved survival included fewer metastatic lesions[hazard ratio(HR):2.51,P=0.045],longer disease-free intervals(HR:0.35,P=0.016),and wedge lung resections(HR:0.42,P=0.035).Multiple PM predicted higher recurrence risk(HR:2.22,P=0.022).The log-rank test showed no significant difference in CSS between single and repeated metastasectomy(P=0.92).CONCLUSION perioperative chemotherapy shows no survival benefit post-PM resection in ***-free intervals and fewer metastatic lesions predict better *** metastasectomy is warranted for eligible patients.

关键词： Pulmonary metastasis Colorectal cancer perioperative chemotherapy Survival Repeated pulmonary metastasectomy

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D2 plus radical resection combined with perioperative chemotherapy for advanced gastric cancer with pyloric obstruction

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Chinese Journal of Cancer Research 2013年第4期25卷 479-481页

作者： Yian Du Xiangdong Cheng Zhiyuan Xu Litao Yang Ling Huang Bing Wang Pengfei Yu Ruizeng Dong Department of Abdominal Surgery Zhejiang Cancer Hospital

A patient with advanced gastric cancer complicated with pyloric obstruction was treated using D2 ＋ radical resection combined with perioperative chemotherapy, and had satisfying outcomes. The perioperative chemotherapy regimen was Taxol and S1 （tegafur, gimeracil, and oteracil）. Three cycles of neoadjuvant chemotherapy were delivered before surgery, and three cycles of adjuvant therapy after surgery. PR was achieved after chemotherapy. D2 ＋ dissection of stations 8p, 12b, 12p, 13 and 14v lymph nodes was performed on September 10, 2012.

关键词： Advanced gastric cancer pyloric obstruction D2 + lymph node dissection perioperative chemotherapy

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Use of perioperative chemotherapy in colorectal cancer metastatic to the liver

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Gastroenterology Report 2019年第5期7卷 301-311,I0001页

作者： Lynn K.Symonds Stacey A.Cohen Division of Oncology University of WashingtonSeattleWAUSA Clinical Research Division Fred Hutchinson Cancer Research CenterSeattleWAUSA

A curative-intent approach may improve survival in carefully selected patients with oligometastatic colorectal *** treatments are most frequently administered to patients with isolated liver metastasis,though they may be judiciously considered for other sites of *** be considered for curative intent with surgery,patients must have disease that can be definitively treated while leaving a sufficient functional liver *** chemotherapy may be used for upfront resectable disease as a test of tumor biology and/or for upfront unresectable disease to increase the likelihood of resectability(so-called‘conversion’chemotherapy).While conversion chemotherapy in this setting aims to improve survival,the choice of a regimen remains a complex and highly individualized *** this review,we discuss the role of RAS status,primary site,sidedness,and other clinical features that affect chemotherapy treatment selection as well as key factors of patients that guide individualized patient-treatment recommendations for colorectal-cancer patients being considered for definitive treatment with metastasectomy.

关键词： metastatic colorectal cancer perioperative chemotherapy conversion chemotherapy liver resection KRAS steatohepatitis

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Towards personalized perioperative treatment for advanced gastric cancer

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World Journal of Gastroenterology 2014年第33期20卷 11586-11594页

作者： Ru-Lin Miao Ai-Wen Wu Key Laboratory of Carcinogenesis and Translational Research Ministry of Education Department of Gastrointestinal Surgery Peking University Cancer Hospital Beijing Cancer Hospital and Institute

Gastric cancer is one of the most frequently diagnosed cancers worldwide. Although the rate of gastric cancer has declined dramatically over the past decades in most developed Western countries, it has not declined in East Asia. Currently, a radical gastrectomy is still the only curative treatment for gastric cancer. Over the last twenty years, however, surgery alone has been replaced by a multimodal perioperative approach. To achieve the maximum benefit from the perioperative treatment, a thorough evaluation of the tumor must first be performed. A complete assessment of gastric cancer is divided into two parts: staging and histology. According to the stage and histology of the cancer, perioperative chemotherapy or radiochemotherapy can be implemented, and perioperative targeted therapies such as trastuzumab may also play a role in this field. However, perioperative treatment approaches have notbeen widely accepted until a series of clinical trials were performed to evaluate the value of perioperative treatment. Although multimodal perioperative treatment has been widely applied in clinical practice, personalization of perioperative treatment represents the next stage in the treatment of gastric cancer. Genomic-guided treatment and efficacy prediction using molecular biomarkers in perioperative treatment are of great importance in the evolution of treatment and may become an ideal treatment method.

关键词： Gastric cancer Pre-therapeutic evaluation perioperative chemotherapy perioperative radiochemotherapy perioperative target therapy

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Between evidence and new perspectives on the current state of the multimodal approach to gastric cancer:Is there still a role for radiation therapy?

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World Journal of Gastrointestinal Oncology 2018年第9期10卷 271-281页

作者： Linda Agolli Luca Nicosia Department of Radiation Oncology Faculty of Medicine and University Hospital Carl Gustav CarusTechnische Universit?t Dresden Department of Radiation Oncology Sant'Andrea HospitalSapienza University of Rome

In patients affected by gastric cancer(GC), especially those in advanced stage, the multidisciplinary app-roach of treatment is fundamental to obtain a good disease control and quality of life. Although many chemotherapeutics in combination to radiotherapy are adopted in the peri- or postoperative setting, the most optimal timing, regimens and doses remains con-troversial. In the era of radical surgery performed with D2-lymphadenectomy, the role of radiation therapy remains to be better defined. Categories of patients, who could benefit more from an intensified local trea-tment rather than more toxic systemic therapy, are still under investigation. Evidence and recent updates of the randomized trials, meta-analysis and prospective trials show that the postoperative radiotherapy plays a fundamental role in reducing the loco-regional recurrence and in turn the disease-free survival in operable advanced GC patients, also after a well performed D2 surgery. Therapeutic decisions should be taken considering the individual patients, but the multimodal approach is necessary to guarantee a longer survival and a good quality of life. Ongoing randomized trials could better define the timing and the combination of radiotherapy and systemic therapy.

关键词： Adjuvant chemoradiation Locally advanced perioperative chemotherapy Gastric cancer Combined treatment

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perioperative Treatment in Gastric Cancer—Developments in Patient Selection

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Journal of Cancer Therapy 2018年第2期9卷 101-105页

作者： Manuela Machado Helena Magalhaes Mário Fontes-Sousa Medical Oncology Department Portuguese Institute of Oncology of Porto(IPO Porto)PortoPortugal

Gastric cancer (GC) is a major public health issue. It is considered the 5th most common cancer diagnosed worldwide and it is one of the main causes of malignant disease-associated morbidity and mortality. The cornerstone of curative treatment is still surgery, and since the rate of relapse is high, a multidisciplinary approach is warranted in most developed countries. And while there have been recent developments in the perioperative scenario namely the FLOT regimen, little has advanced considering patient selection. We have reviewed the major trials in this setting and provide some insights from recently reported microsatellite instability (MSI) in a subgroup analysis in the MAGIC trial patients that seem to suggest an opportunity to patient selection. Furthermore, GC subtyping may prove helpful selecting candidates to immunotherapy or even multimodal therapy in the future. As the paradigm is moving towards a precision oncology model, GC patient selection remains one the biggest challenges in oncology but seems closer to clinical practice reality as new developments are being reported.

关键词： Gastric Cancer perioperative chemotherapy Molecular Classification of Gastric Cancer MSI

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