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Stiffness-tuned and ROS-sensitive hydrogel incorporating complement C5a receptor antagonist modulates antibacterial activity of macrophages for periodontitis treatment

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Bioactive Materials 2023年第7期25卷 347-359页

作者： Ziqi Gan Zecong Xiao Zhen Zhang Yang Li Chao Liu Xin Chen Yuanbo Liu Dongle Wu Chufeng Liu Xintao Shuai Yang Cao Hospital of Stomatology Guangdong Provincial Key Laboratory of StomatologyGuanghua School of StomatologySun Yat-sen UniversityGuangzhou510055China Nanomedicine Research Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou510630China Stomatological Hospital Southern Medical UniversityGuangzhou510260China

periodontitis is admittedly a microbe-driven intractable infectious disease,in which Porphyromonas gingivalis(Pg)plays a keystone *** can selectively impair the antimicrobial responses of periodontal resident macrophages including their phagocytic and bactericidal activity without interfering their proinflammatory activity,which leads to microflora disturbance,destructive periodontal inflammation and alveolar bone loss ***,an injectable ROS-sensitive hydrogel is developed for releasing active bone marrow-derived macrophages(named ex-situ macrophages hereafter)and a complement C5a receptor antagonist(C5A)to the gingival *** appropriately tuning the hydrogel stiffness,the phagocytic activity of these macrophages is greatly enhanced,reaching an optimal performance at the elastic modulus of 106 ***,C5A avoids undesired C5a receptor activation by Pg to ensure the bacterial killing activity of both the ex-situ and in-situ ***,the ROS-sensitive hydrogels show another distinct feature of decreasing the ROS level in periodontal niche,which contributes to the alleviated periodontal inflammation and attenuated bone loss as *** study highlights the potential of utilizing hydrogels with tailored biomechanical properties to remodel the functions of therapeutic cells,which is expected to find wide applications even beyond periodontitis treatment.

关键词： periodontitis treatment Cell therapy ROS-Responsive hydrogels C5a receptor blockade Mechanostimulation

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Activating MoO_(3) nanobelts via aqueous intercalation as a near-infrared type I photosensitizer for photodynamic periodontitis treatment

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SmartMat 2023年第6期4卷 112-124页

作者： Bohua Li Dandan Chu Haohao Cui Zhanrong Li Zhan Zhou Chaoliang Tan Jingguo Li Henan Provincial People's Hospital People's Hospital of Zhengzhou UniversityZhengzhouChina College of Chemistry and Chemical Engineering Henan Key Laboratory of Function-Oriented Porous MaterialsLuoyang Normal UniversityLuoyangChina Department of Electrical and Electronic Engineering The University of Hong KongHong Kong SARChina

Although molybdenum trioxide nanomaterials have been widely explored as nanoagents for biomedical applications against bacteria through photothermal therapy,chemodynamic therapy,and catalytic therapy,their utilization as photosensitizers for photodynamic therapy(PDT)have been rarely reported so ***,we report the activation of MoO_(3) nanobelts via aqueous co-intercalation of Na+and H_(2)O into their van der Waals gaps as a near-infrared Type I photosensitizer for photodynamic periodontitis *** Na^(+)/H_(2)O intercalation of MoO_(3) nanobelts can shorten its length,generate rich oxygen vacancies,and enlarge its interlayer *** structural changes thus can induce the color change from white to dark blue with a strong near-infrared(NIR)*** used as a photosensitizer,the I-MoO_(3−x) nanobelts exhibit much higher activities for the generation of superoxide radical(·O_(2)^(−))under an 808 nm laser irradiation than that of the pristine MoO_(3) ***,the prepared I-MoO_(3)−x nanobelts show a spectral antibacterial activity against Escherichia coli and Saccharomyces aureus,thus yielding a good clinical therapeutic effect on *** study proves that aqueous intercalation can be a simple but powerful strategy to activate layered MoO_(3) nanomaterials for high-performance PDT.

关键词： intercalation MoO_(3) nanobelts periodontitis treatment photodynamic therapy Type I photosensitizer

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