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perichondrial progenitor cells promote proliferation and chondrogenesis of mature chondrocytes

Regenerative Biomaterials 2022年第1期9卷 424-433页

作者： Chien-Liang Ho Lynn L.H.Huang Shyh-Jou Shieh Institute of Clinical Medicine College of MedicineNational Cheng Kung University138 Sheng-Li RoadTainan 70403TaiwanChina Division of Plastic and Reconstructive Surgery Department of SurgeryNational Cheng Kung University HospitalCollege of MedicineNational Cheng Kung University138 Sheng-Li RoadTainan 70403TaiwanChina Research Center of Excellence in Regenerative Medicine National Cheng Kung University1 University RoadTainan 70101TaiwanChina Department of Biotechnology and Bioindustry Sciences College of Bioscience and BiotechnologyNational Cheng Kung University1 University RoadTainan 70101Taiwan International Center for Wound Repair and Regeneration National Cheng Kung University1 University RoadTainan 70101TaiwanChina School of Medicine National Cheng Kung University1 University RoadTainan 70101TaiwanChina

Autologous chondrocytes(C cells)are effective sources of cell therapy for engineering cartilage tissue to repair chondral defects,such as degenerative *** expansion of cells with C cell characteristics has become a major challenge due to inadequate donor sites and poor proliferation of mature C *** perichondrial progenitor cells(P cells)from the cambium layer of the perichondrium possessed significantly higher mesenchymal stem cell markers than C *** the transwell co-culture system,P cells increased the passaging capacity of C cells from P6 to P9,and the cell number increased 128 *** system increased the percentage of Alcian blue-positive C cells from 40%in P6 to 62%in P9,contributing about 198 times more Alcian blue-positive C cells than the control group.C cells co-cultured with P cells also exhibited higher proliferation than C cells cultured with P cellconditioned *** results were obtained in nude mice that were subcutaneously implanted with C cells,P cells or a mixture of the two cell types,in which the presence of both cells enhanced neocartilage formation in ***,P cells enhanced the proliferation of C cells in a dose–dependent manner and prolonged the longevity of mature C cells for clinical applications.

关键词： chondrocytes cell proliferation perichondrial progenitor cells paracrine effect neocartilage formation

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