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Nociception-induced spatial and temporal plasticity of synaptic connection and function in the hippocampal formation of rats

Nociception-induced spatial and temporal plasticity of synap...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Ming-Gang LIU~1,Xiao-Yan ZHAO~1,Yan WANG~2,Dong-Liang YUAN~2,Xue-Feng CHEN2,Rui-Rui WANG~2,Jun CHEN~(1,2,*) 1 Institute for Biomedical Sciences of Pain,Capital Medical University,Beijing 100069,China 2 Institute for Biomedical Sciences of Pain and Institute for Functional Brain Disorders,Tangdu Hospital,Fourth Military Medical University,Xi''an 710038,China

＜正＞Objective Pain is known to be processed by a complex neural network（neuromatrix） in the *** is hypothesized that under pathological state,persistent or chronic pain can affect various higher brain functions through ascending pathways,leading to co-morbidities or mental disability of ***,so far the influences of pathological pain on the higher brain functions are less clear and this may hinder the advances in pain *** In the current study,by virtue of a well-developed multi-electrode array technique,we established an in vitro ’neural network’ model for studying spatiotemporal plasticity of synaptic connection and function in the hippocampal formation（HF） in response to persistent *** waveform of the field excitatory postsynaptic potential（fEPSP）,induced by perforant path electrical stimulation and pharmacologically identified as being activity-dependent and mediated by ionotropic glutamate receptors,was consistently positive-going in the dentate gyrus（DG）,while that in the CA1 was negative-going in shape in naive and saline control *** For the spatial characteristics of synaptic plasticity,persistent pain significantly increased the number of detectable fEPSP in both DG and CA1 areas at the network level and distinctly enhanced the input-output function of individual synaptic efficacy at the cellular *** the temporal plasticity,long-term potentiation produced by theta burst stimulation conditioning was also remarkably enhanced by ***,it is strikingly noted that the shape of fEPSP waveform was drastically deformed or split by the conditioning stimulus under the condition of persistent nociception,while that in naive or saline control state was not *** these changes in synaptic connection and function were further confirmed by the 2-dimentional current source density *** an initial step in dissecting the mechanisms underlying this phenomenon,we performed infrared differential interferen

关键词： persistent nociception hippocampal formation perforant path synaptic plasticity multi-electrode-array

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