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Effects of perfluorooctane on the retina as a short-term and small amounts remnant in rabbits

International Journal of Ophthalmology(English edition) 2019年第3期12卷 381-386页

作者： Qing-Chen Li Jian Yu Chun-Hui Jiang Hao-Hao Zhu Kun Liu Jin-Chuan Zhao Department of Ophthalmology and Vision Science Eye and ENT Hospital Fudan University Key Laboratory of Myopia of State Health Ministry and Key Laboratory of Visual Impairment and Restoration of Shanghai Department of Ophthalmology People's Hospital of Shanghai No.5 Department of Ophthalmology Shanghai General Hospital ZHEJIANG Institute of Medical Device Supervision and Testing

AIM: To investigate changes in the rabbit retina after shortterm and small amounts tamponade of perfluorooctane(PFO).METHODS: New Zealand rabbits were used, and 48 eyes were randomly and evenly assigned into four different groups. The PFO groups received a residue of 0.1 mL of PFO for ophthalmic surgery or 0.1 mL of F-Octane at the end of surgery; eyes from the pars plana vitrectomy(PPV) group were filled with balanced salt solution and those having not received surgical intervention served as controls. Eyes were collected at 1, 4 and 12 wk and ***: Under a microscope, nuclear counts of the inner nuclear layer(INL) and outer nuclear layer(ONL) did not differ among the four groups at all time points; however, slight disarrangement of the ONL and occasional vacuolization of the INL were found in the inferior retina only at 12 wk in two PFO groups. Four of the groups had similar results of Caspase-3 and TNF-α staining at all time points. Alternatively, IL-8 was increased in PFOa and PPV control groups at 4 wk and in all three PPV groups at 12 wk; also, the apoptotic index(%) was similarly increased in all three PPV groups at 4 and 12 ***: Both PFOs are well tolerated in rabbit eyes for up to 12 wk, which suggests that they can be used safely as intraoperative tools or for short-term and small amounts tamponade after surgery.

关键词： perfluorooctane retinal damage tamponade

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