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Change and significance of T-cell subsets and TNF-α in patients with advanced malignant obstructive jaundice treated by percutaneous transhepatic biliary external and internal drainage

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Frontiers of Medicine 2007年第4期1卷 364-368页

作者： ZHU Lidong CHEN Xiaoping Department of Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Surgery Linyi Tumor HospitalLinyi 276001China

The aim of this article was to study the influence of immunity function of advanced malignant obstructive jaundice(MOJ)treated by percutaneous transhepatic biliary external and internal ***-six cases of MOJ were divided into two groups according to the different ways of biliary ***-two external drainage tubes were placed in 41 cases of percutaneous transhepatic biliary exter-nal drainage group and 66 metal stents were placed in 55 cases of percutaneous transhepatic biliary internal drainage *** function,serum TNF-α and cellular function were examined one day before operation and one week after operation and liver function was re-examined two weeks after operation,in order to observe the change and analyze the association among them and compare with the control *** patients’conditions were improved after *** the percutaneous transhepatic biliary external and internal drainage groups,the total level of bilirubin decreased from(343.54±105.56)μmol/L and(321.19±110.50)μmol/L to(290.56±103.46)μmol/L and(283.72±104.95)μmol/L after operation respectively,which were significantly lower than pre-operation(P0.05).Serum alanine aminotransferase(ALT)of all patients one week after opera-tion was significantly lower than that before ***-a in percutaneous transhepatic biliary external and internal groups decreased from(108.58±19.95)pg/mL,(109.98±16.24)pg/mL of pre-operation to(104.32±19.59)pg/mL,(83.92±13.43)pg/mL of post-operation respectively,there was notable improvement(Pinternal drainage group after ***’serum CD4,CD3 and CD4/CD8 were notably increased,but CD8 was notably decreased(Pexternal drainage group(P>0.05).There was a significant difference between the two *** TNF-α and ALT had positive *** transhepatic biliary internal or external drain-age was an effective

关键词： jaundice,obstructive percutaneous transhepatic biliary external and internal drainage TNF-α

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