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Translation of the long-term fundamental studies on viral DNA packaging motors into nanotechnology and nanomedicine

Science China(Life Sciences) 2020年第8期63卷 1103-1129页

作者： Chenxi Liang Tao Weitao Lixia Zhou Peixuan Guo Center for RNA Nanobiotechnology and Nanomedicine College of PharmacyCollege of MedicineDorothy M.Davis Heart and Lung Research Instituteand Comprehensive Cancer Center.The Ohio State UniversityColumbusOhio 43210USA Biology Department College of Science and MathematicsSouthwest Baptist UniversityBolivarMissouri 65613USA

Many years of fundamental studies on viral genome packaging motors have led to fruitful *** double-stranded DNA(dsDNA)viruses package their genomes into preformed protein shells via nanomotors including several elegant and meticulous coaxial *** motor is geared by the hexameric RNA *** open washer displayed as hexametric string of phi29 motor ATPase has been *** open washer linked into a filament as a queue with left-handed chirality along the dsDNA *** was found that a free 5′-and 3′-dsDNA end is not required for one gp16 dimer and four monomers to assemble into the hexametric washer on *** above studies have inspired several applications in nanotechnology and *** applications include:(i)studies on the precision motor channels have led to their application in the single pore sensing;(ii)investigations into the hand-in-hand integration of the hexametric pRNA ring have resulted in the emergence of the new field of RNA nanotechnology;and(iii)the studies on the motor stoichiometry of homologous multi-subunits that subsequently have inspired the discovery of new methods in highly potent drug *** review focuses on the structure and function of the viral DNA packaging motors and describes how fundamental studies inspired various *** these advantages,more nanotechnological and biomedical applications using bacteriophage motor components are expected.

关键词： nanopores packaging motor phi29 pRNA single pore sensing chemical detection peptide differentiation and sensing nanotechnology nanobiotechnology

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