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Acceptance and Factors Associated With Participation in Functional Cure–Related Trials Among people living with hiv: A Cross-sectional Study in Southern China

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Infectious Microbes & Diseases 2024年第1期6卷 11-19页

作者： Zhaomin Deng Minjuan Shi Yue Yuan GuangjinCao Chunyan Wen Lijuan Chen Xueying Fan Linan Wu Jianhui Yuan Huachun Zou Linghua Li Caijun Sun School of Public Health(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhenChina Department of Diseases Control Panyu District Center for Disease Control and PreventionGuangzhouChina Infectious Disease Center Guangzhou Eighth People's HospitalGuangzhou Medical UniversityGuangzhouChina Nanshan District Center for Disease Control and Prevention ShenzhenChina Key Laboratory of Tropical Disease Control(Sun Yat-sen University) Ministry of EducationGuangzhouChina

hiv remains a global health challenge,and research efforts directed towards a functional cure require people living with hiv(PLhiv)in-volvement in clinical *** study assessed willingness to participate in hiv functional cure–related clinical trials and associated factors among PLhiv in Guangzhou,China,using a questionnaire survey *** analyzed responses from 718 questionnaires,finding that 71.2%were willing to participate in Phase Ⅲtrials,while 51.7%were willing to participate in Phase I trials and 42.9%expressed acceptability for analytic treatment *** logistic regression demonstrated that male PLhiv,those with awareness of functional cure,and PLhiv,who had been on antiretroviral therapy(ART)for less than 1 year,were more willing to partic-ipate in Phase Ⅲ*** with a body mass index greater than 24,and those without resistance to ART drug were more willing to participate in Phase I *** major motivations for participation in Phase Ⅲtrials were access to cutting-edge treatments(62.6%)and supporting research(55.3%).Safety was the main concern contributing to *** study revealed a high willingness to participate in hiv functional cure–related trials among PLhiv in Guangzhou,China,and willingness varied across different trial phases and was influenced by multiple *** study provides valuable references for future clinical trial recruitment strategies and public health policy formulation.

关键词： people living with hiv functional cure clinical trials willingness

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A preliminary validation of the Brief COPE instrument for assessing coping strategies among people living with hiv in China

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Infectious Diseases of Poverty 2015年第1期4卷 334-343页

作者： Xiao-you Su Joseph TF Lau Winnie WS Mak KC Choi Tie-jian Feng Xi Chen Chu-liang Liu Jun Liu De Liu Lin Chen Jun-min Song Yan Zhang Guang-lu Zhao Zhang-ping Zhu Jin-quan Cheng Chinese Academy of Medical Sciences&Peking Union Medical College BeijingChina JC School of Public Health and Primary Care The Chinese University of Hong KongCUHK Shenzhen Research InstituteShenzhenChina Department of Psychology The Chinese University of Hong KongHong KongChina. Shenzhen Chronic Disease Hospital ShenzhenChina Hunan Province CDC HengyangChina Hengyang City CDC HengyangHunan ProvinceChina The 5th Hospital HengyangHunan ProvinceChina Shenzhen CDC ShenzhenChina The 3rd Hospital HengyangHunan ProvinceChina

Background:The Brief COPE instrument has been utilized to conduct research on various populations,including people living with hiv(PLWH).However,the questionnaire constructs when applied to PLWH have not been subjected to thorough factor ***:A total of 258 PLWH were recruited from two provinces of *** answered questions involving the scales of three instruments:the Brief COPE,the Perceived Social Support Scale,and the Perceived Discrimination Scale for *** factor analysis(CFA)and exploratory factor analysis(EFA)were ***:The CFA found a poor goodness of fit to the *** subsequent EFA identified six preliminary factors,forming subscales with Cronbach’s alphas,which ranged from 0.61 to *** correlation coefficients between the subscales and measures of perceived social support and perceived discrimination were reported,giving preliminary support to the validity of the new empirical factor ***:This study showed that the original factor structure of the Brief COPE instrument,when applied to PLWH in China,did not fit the ***,the Brief COPE should be applied to various populations and cultures with *** new factor structure established by the EFA is only preliminary and requires further validation.

关键词： people living with hiv Brief COPE Confirmatory factor analysis Explanatory factor analysis Perceived Social Support Scale Perceived Discrimination Scale for PLWH China

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Epidemiology of Lower Extremity Artery Disease in people living with hiv Followed at the Departmental University Hospital Center Ouémé-Plateau in 2019

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Open Journal of Epidemiology 2023年第4期13卷 401-411页

作者： Yèssito Corine Nadège Houehanou Armand Wanvoègbe Luc Béhanzin Djidjoho Arnaud Sonou Ursule Kanhonou Maurice Agonnoudé David Houéto Thierry Adoukonou National School of Public Health (ENATSE) University of Parakou Parakou Benin Department of Internal Medicine University Departmental Hospital Ouéme-Plateau Porto-Novo Benin University Clinic of Cardiology University National Hospital CNHU-HKM Cotonou Benin

Introduction: Lower extremity artery disease (LEAD) is a serious cardiovascular disease. people living with the human immunodeficiency virus (hiv) are at risk. The aim of the study was to determine the prevalence of LEAD and identify the associated factors among people living with hiv who were followed at the departmental university hospital Ouémé-Plateau in Benin. Methods: This was a cross-sectional study. It included all hiv-infected people who were monitored at the department of medicine of the target hospital during the study period and met the inclusion criteria (followed for at least three months, aged at least 25 years, and having given their written consent to participate). Data were collected during an individual interview, followed by the measurement of parameters. The ankle brachial index ≤ 0.9 was used for the diagnosis of LEAD. Associated factors were searched through a multivariable logistic regression. Results: The prevalence of LEAD was 34.2% among 222 respondents having a mean age was 42.9 ± 10.8 years and a female predominance (77.5%). No significant association was found between the presence of LEAD and sociodemographic factors. The presence of LEAD was significantly associated with hypertension and antiretroviral therapy. Hypertensive patients had a higher risk of LEAD compared to non-hypertensive patients (OR = 1.98, 95% CI [1.04-3.83], p = 0.037). Those who were receiving second-line therapy also had a higher risk of LEAD compared to those on first-line therapy (OR = 2.95, 95% CI [1.14-7.60], p = 0.025). Conclusion: This study showed a high prevalence of LEAD especially among hypertensive patients and those who were receiving second-line antiretroviral therapy. LEAD diagnosis and management should be included in the routine care of people living with hiv in Benin.

关键词： Lower Extremity Arterial Disease people living with hiv Benin

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Associations of PNPLA3 and LEP genetic polymorphisms with metabolic-associated fatty liver disease in Thai people living with human immunodeficiency virus

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World Journal of Hepatology 2024年第3期16卷 366-378页

作者： Kanuengnit Choochuay Punna Kunhapan Apichaya Puangpetch Sissades Tongsima Pornpen Srisawasdi Abhasnee Sobhonslidsuk Somnuek Sungkanuparph Mohitosh Biswas Chonlaphat Sukasem Program in Translational Medicine Faculty of Medicine Ramathibodi HospitalMahidol UniversityBangkok 10400Thailand School of Pharmacy Walailak UniversityNakhon Si Thammarat 80161Thailand Laboratory for Pharmacogenomics Division of Pharmacogenomics and Personalized MedicineSomdech Phra Debaratana Medical CenterDepartment of PathologyFaculty of Medicine Ramathibodi HospitalMahidol UniversityBangkok 10400Thailand Department of Medical Sciences Ministry of Public HealthNonthaburi 11000Thailand National Biobank of Thailand National Center for Genetic Engineering and BiotechnologyPathum Thani 12120Thailand Division of Clinical Chemistry Department of PathologyFaculty of Medicine Ramathibodi HospitalMahidol UniversityBangkok 10400Thailand Division of Gastroenterology and Hepatology Department of MedicineFaculty of Medicine Ramathibodi HospitalMahidol UniversityBangkok 10400Thailand Chakri Naruebodindra Medical Institute Faculty of Medicine Ramathibodi HospitalMahidol UniversitySamut Prakan 10540Thailand Department of Pharmacy University of RajshahiRajshahi 6205Bangladesh Pharmacogenomics Clinic Bumrungrad Genomic Medicine InstituteBumrungrad International HospitalBangkok 10110Thailand Research and Development Laboratory Bumrungrad International HospitalBangkok 10110Thailand MRC Centre for Drug Safety Science Department of Pharmacology and TherapeuticsInstitute of SystemsMolecular and Integrative BiologyUniversity of Liverpool Liverpool L693GLUnited Kingdom Faculty of Pharmaceutical Sciences Burapha UniversityChonburi 20131Thailand

BACKGROUND The prevalence of metabolic-associated fatty liver disease(MAFLD)is a growing public health issue in people living with human immunodeficiency virus(PLWH).However,the pathophysiology of MAFLD is still unknown,and the role of genetic variables is only now becoming *** To evaluate the associations of gene-polymorphism-related MAFLD in *** The study employed transient elastography with a controlled attenuation parameter≥248 dB/m to identify MAFLD in patients from a Super Tertiary Hospital in central *** single-nucleotide polymorphisms(SNPs)were genotyped using TaqMan®MGB probe 5'nuclease assays for seven MAFLD-related *** analyses included SNP frequency analysis,Fisher's Exact and Chi-square tests,odds ratio calculations,and multivariable logistic *** The G-allele carriers of PNPLA3(rs738409)exhibited a two-fold rise in MAFLD,increasing by 2.5 times in MAFLD with human immunodeficiency virus *** clinical features and genetic patterns imply that LEP rs7799039 A-allele carriers had a nine times(P=0.001)more significant chance of developing aberrant triglyceride among *** The current study shows an association between PNPLA3 rs738409 and LEP rs7799039 with MAFLD in PLWH.

关键词： PNPLA3 LEP Metabolic-associated fatty liver disease people living with hiv Thai

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Socio-Demographic and Occupational Aspects of hiv-HBV Co-Infection in Bangui, Central African Republic (CAR): Hospital-Based Cross-Sectional Study

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Advances in Infectious Diseases 2024年第2期14卷 310-321页

作者： Gaspard Tékpa Hermione Dahlia Mossoro-Kpinde Jessy Guylaine Nazilari Gertrude Komoyo Saint Calvaire Henri Diémer Centre Hospitalier Universitaire de lAmiti Bangui Central African Rpublic (CAR) Dpartement de Mdecine Facult des Sciences de la Sant Universit de Bangui Bangui Central African Republic (CAR) Direction de la Mdecine du Travail Ministre du Travail de lemploi et de la Protection Sociale Bangui Central African Rpublic (CAR) Dpartement de Sant Publique Facult des Sciences de la Sant Universit de Bangui Bangui Central African Rpublic (CAR)

Objective: hiv-HBV co-infection is a major public health problem that has not been sufficiently explored in the Central African workplace. The aim of this study was to assess the frequency of hiv-HBV co-infection among people who living with hiv (PLhiv) in the infectious and tropical diseases department of the Centre Hospitalier Universitaire de lAmiti Sino-Centrafricaine in Bangui. Methods: A retrospective study was carried out from January 1, 2010 to December 31, 2021 in the Infectious and Tropical Diseases Department at the Amiti Sino-Centrafricaine University Hospital. It included the files of all PLhiv, which included the results of HBV serology. A standardized form was used to collect socio-demographic and professional data by documentary review. Data was analysed using Epi-Info 7 software. Means, proportions were calculated as well as Chi square witch was significant if p-value was below 0.05. Results: The study included 265 patients, 188 were women (70.1%) and 77 men (29.1%), giving a sex ratio of 0.45. Mean age was 35.8 years, higher in men (40 years) than in women (35.8 years) (p 0.0001). The age groups 25 to 34 (37.7%) and 35 to 44 (33.6%) were in the majority (71.3%). The majority of PLhiv were unemployed (57.1%), including housewives (43.0%). HBV prevalence was 14.3%, including 7.2% among the unemployed, who account for half of all co-infections. The search for associations between hiv-HBV co-infection and all socio-demographic characteristics (age, sex, marital status) and socio-professional categories showed no significant difference (p 0.05). Conclusion: PLhiv were predominantly young adults, female, and unemployed;no occupation was significantly associated with co-infection. The vast majority of co-infected people were not covered by the occupational health system (unemployed or informal sector). Urgent action is needed to improve workers access to occupational medicine in CAR.

关键词： people living with hiv hiv-HBV Co-Infection Occupation Informal Sector

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Virome in immunodeficiency:what we know currently

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Chinese Medical Journal 2023年第22期136卷 2647-2657页

作者： Hu Wang Siqi Xu Shuang Li Bin Su Scott Sherrill-Mix Guanxiang Liang Beijing Key Laboratory for hiv/AIDS Research Clinical and Research Center for Infectious DiseasesBeijing Youan HospitalCapital Medical UniversityBeijing 100069China Center for Infectious Disease Research School of MedicineTsinghua UniversityBeijing 100084China Tsinghua-Peking Center for Life Sciences Beijing 100084China Department of Microbiology&Molecular Genetics Michigan State UniversityEast LansingMI 48824USA

Over the past few years,the human virome and its complex interactions with microbial communities and the immune system have gained recognition as a crucial factor in human *** with compromised immune function encounter distinctive challenges due to their heightened vulnerability to a diverse range of infectious *** review aims to comprehensively explore and analyze the growing evidence regarding the role of the virome in immunocompromised disease *** surveying the latest literature,we present a detailed overview of virome alterations observed in various immunodeficiency *** then delve into the influence and mechanisms of these virome changes on the pathogenesis of specific diseases in immunocompromised ***,this review explores the clinical relevance of virome studies in the context of immunodeficiency,highlighting the potential diagnostic and therapeutic gains from a better understanding of virome contributions to disease manifestations.

关键词： Human virome Immunodeficiency people living with hiv PLWH Diagnosis Therapeutics Autoimmune diseases Organ transplantation

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The Impact of hiv Spending on Health Outcomes in Thailand

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World Journal of AIDS 2021年第3期11卷 85-100页

作者： Shaheda Viriyathorn Saranya Sachdev Yaowaluk Wanwong Walaiporn Patcharanarumol Viroj Tangcharoensathien International Health Policy Program (IHPP) Ministry of Public Health Nonthaburi Thailand

Background: The Sustainable Development Goals commitment to Ending hiv/AIDS by 2030 requires sustained adequate investment. This study sought to examine the association between hiv/AIDS spending and outcomes in Thailand between 2008 and 2019. Methods: A quantitative secondary data analysis with time-series was conducted using a retrospective dataset of hiv spending and some selected outcomes including the number of people living with hiv (PLhiv), incidence and prevalence of hiv/AIDS, the prevention of mother-to-child transmission (PMTCT) and AIDS-related deaths. Data were obtained from a diverse set of sources. Descriptive statistics and univariate regression model were used to analyze hiv expenditure and outcomes. Results: hiv spending per PLhiv rose by two folds from $347 in 2008 to more than $600 in 2019, mostly financed by domestic sources. This increase of domestic resources per PLhiv was significantly associated with better hiv-related outcomes especially in the reduction of PLhiv and AIDS-related deaths through increased number of people receiving antiretroviral therapy (ART). However, the spending per PLhiv varied across the three public health insurance schemes. Comparison of hiv expenditure and health outcomes across upper-middle-income countries shows Thailand is not highly ranked in terms of spending efficiency despite having made good progress. Conclusion: Domestic financing for hiv programs is indispensable for achieving the goal of ending AIDS. Despite significant improvement in hiv-related outcomes, challenges remain in achieving the 90-90-90 goal. The redesigning of payment methods should be considered to increase the efficiency of hiv financing. Other factors related to strengthening the health system should not be overlooked.

关键词： hiv Spending Healthcare Financing hiv Infections hiv Outcome Assessment people living with hiv Thailand

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Primary Effusion Lymphoma in a hiv-1/2-Infected Patient

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World Journal of AIDS 2023年第3期13卷 116-124页

作者： Maria Caixas Lima Pedro Vasques Andreia Paulos André Valente Joana Santos Carla Antunes Matilde Gonçalves Maria Isabel Casella Nuno Luis José Poças Department of Infectious Diseases Hospital de S&#227o Bernardo Centro Hospitalar de Setúbal Setúbal Portugal Department of General Surgery Hospital de S&#227o Bernardo Centro Hospitalar de Setúbal Setúbal Portugal Department of Hematology Hospital de Santo António dos Capuchos Centro Hospitalar Lisboa Central Lisboa Portugal Department of Anatomical Pathology Hospital de S&#227o Bernardo Centro Hospitalar de Setúbal Setúbal Portugal

Background: Primary effusion lymphoma (PEL) is a lymphoid proliferation related to Kaposi sarcoma herpesvirus 8/human herpesvirus 8 (KSHV/HHV8) that affects mainly human immunodeficiency virus (hiv) infected individuals but can also occur in other immunodeficiency settings. It is characterized by lymphomatous effusions in different serous body cavities without the presence of a detectable tumor mass. The diagnosis is challenging and the clinical outcomes are poor. Aim: The aim of this paper is to report a rare case of PEL in a man who have sex with women (MSW) with hiv-1/2 infection, history of visceral Kaposi sarcoma (KS) and the development of a seronegative arthritis previous to the lymphoproliferative disease diagnosis. PEL presented with ascites, was treated with high-dose chemotherapy and autologous stem cell transplantation, with a good clinical outcome. Case Presentation: We describe a case of a 48-year-old hiv-1/2-infected patient from a high HHV8 seroprevalent country, hospitalized following a three-month history of increased abdominal volume and general constitutional symptoms. Laboratory data revealed normocytic normochromic anemia and a high level of lactate dehydrogenase. A diagnostic paracentesis was performed with cytology compatible with high-grade B-cell lymphoma. Peritoneal fluid cytology showed large lymphoid cells expressing leucocyte-common antigen CD45 without expression of the CD20 antigen (B-lymphocytes) and positivity for HHV8 by immunocytochemical staining, compatible with the diagnosis of PEL.

关键词： Primary Effusion Lymphoma Acquired Immunodeficiency Syndrome hiv-1 hiv-2 Kaposi Sarcoma Herpesvirus 8/Human Herpesvirus 8 people living with hiv

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